Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jörg Pabel"'
Autor:
Laura Isigkeit, Tim Hörmann, Espen Schallmayer, Katharina Scholz, Felix F. Lillich, Johanna H. M. Ehrler, Benedikt Hufnagel, Jasmin Büchner, Julian A. Marschner, Jörg Pabel, Ewgenij Proschak, Daniel Merk
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Generative deep learning models enable data-driven de novo design of molecules with tailored features. Chemical language models (CLM) trained on string representations of molecules such as SMILES have been successfully employed to design new
Externí odkaz:
https://doaj.org/article/18a8f717a7c64c0f81f6b3644f448ee3
Autor:
Jan Vietor, Christian Gege, Tanja Stiller, Romy Busch, Espen Schallmayer, Hella Kohlhof, Georg Höfner, Jörg Pabel, Julian A. Marschner, Daniel Merk
Publikováno v:
Journal of Medicinal Chemistry. 66:6391-6402
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b4985108fec3f9d6e037fa67751e0a3
https://doi.org/10.1021/acs.jmedchem.3c00415
https://doi.org/10.1021/acs.jmedchem.3c00415
Synthesis and biological evaluation of fluorescent GAT-ligands based on meso-substituted BODIPY dyes
Publikováno v:
Medicinal Chemistry Research. 29:301-327
BODIPY dyes are well known for their outstanding spectroscopic properties and are therefore established in a range of fluorescence based analysis techniques for in vitro as well as for in vivo measurements. For the first time, we designed and synthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c91d19f6131b1d58707c4400287e5b3b
https://doi.org/10.1007/s00044-019-02483-6
https://doi.org/10.1007/s00044-019-02483-6
Publikováno v:
ChemMedChem. 11:509-518
Well-known inhibitors of the γ-aminobutyric acid (GABA) transporter GAT1 share a common scaffold of a small cyclic amino acid linked by an alkyl chain to a moiety with two aromatic rings. Tiagabine, the only FDA-approved GAT1 inhibitor, is a typical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1efceec7549efe4b16ebc8c6c236c2
https://doi.org/10.1002/cmdc.201500534
https://doi.org/10.1002/cmdc.201500534
Autor:
Natalia Malikowska, Adrian Podkowa, Klaus T. Wanner, Beata Strach, Elżbieta Wyska, Ewelina Wojcieszak, Katarzyna Kulig, Jörg Pabel, Kinga Sałat, Felix Kern
Publikováno v:
Neuropharmacology. 113
Background and purpose Since GABAergic dysfunction underlies a variety of neurological and psychiatric disorders, numerous strategies leading to the augmentation of GABAergic neurotransmission have been introduced. One of them is the inhibition of GA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a92794eb31b9c030e89403f68ebfef8
https://pubmed.ncbi.nlm.nih.gov/27771379
https://pubmed.ncbi.nlm.nih.gov/27771379
Publikováno v:
Tetrahedron. 66:7279-7287
Three novel sulfur containing chiral bicyclic carboxylic acids were synthesized from d -camphoric acid. Two of these compounds were briefly evaluated for their potency as chiral auxiliaries in Asymmetric Electrophilic α-Amidoalkylation (AEαA) react
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9859b7250f76c122215daa770b94b720
https://doi.org/10.1016/j.tet.2010.07.009
https://doi.org/10.1016/j.tet.2010.07.009
Publikováno v:
Zeitschrift für Naturforschung B. 64:653-661
“Asymmetric Electrophilic α-Amidoalkylation” reactions with a chiral alkylaminocarbonyl unit as chiral auxiliary are used for the stereoselective synthesis of 2-substituted piperidine derivatives. Intramolecular condensation of the nitrogen of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5eb8e2333d835380a41bede86f1c4df
https://doi.org/10.1515/znb-2009-0610
https://doi.org/10.1515/znb-2009-0610
Autor:
Georg Höfner, Miriam Sindelar, Klaus T. Wanner, Marilena Petrera, Thomas Wein, Jörg Pabel, Lars Allmendinger
Publikováno v:
ChemMedChem. 11(5)
A new series of potent and selective mGAT1 inhibitors has been identified, featuring a nipecotic acid residue and an N-butenyl linker with a 2-biphenyl residue at the ω-position. Docking, combined with MD calculations, revealed a binding mode for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110d23656411f5d283f235531ed76675
https://pubmed.ncbi.nlm.nih.gov/26683881
https://pubmed.ncbi.nlm.nih.gov/26683881
An asymmetric synthesis of all four stereoisomers of 1-amino-3-hydroxy-cyclopentane-1-carboxylic acid based on a chiral glycine equivalent, oxazinone derivative is presented. The crucial point of the performed reactions is the alkylation of (S)- and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efff241527d02557a03e53903c7805d
https://ruj.uj.edu.pl/xmlui/handle/item/101711
https://ruj.uj.edu.pl/xmlui/handle/item/101711
Publikováno v:
Tetrahedron. 58:6757-6770
An efficient method for the generation of chiral N-acylpyridinium salts from various pyridines and a chiral acid chloride promoted by means of silyl triflates as additives is presented. The stereoselective addition of organometallic reagents to the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b16ec0bff4e2c37b73abab66a8883a7
https://doi.org/10.1016/s0040-4020(02)00675-0
https://doi.org/10.1016/s0040-4020(02)00675-0