Výsledky vyhledávání - "Jörg Mitterdorfer"

Potassium Currents during the Action Potential of Hippocampal CA3 Neurons

Publikováno v: The Journal of Neuroscience. 22:10106-10115

Central neurons have multiple types of voltage-dependent potassium channels, whose activation during action potentials shapes spike width and whose activation and inactivation at subthreshold voltages modulate firing frequency. We characterized the v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6edde81b0d39f546e24229d26c02bc0
https://doi.org/10.1523/jneurosci.22-23-10106.2002

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Conserved Ca2+-antagonist-binding properties and putative folding structure of a recombinant high-affinity dihydropyridine-binding domain

Autor: Hartmut Glossmann, Irene G. Huber, Alexander Herzog, Edwin Wappl, Jörg Striessnig, Jörg Mitterdorfer, Thierry Langer

Publikováno v: Biochemical Journal. 347:829-836

Sensitivity to 1,4-dihydropyridines (DHPs) can be transferred from L-type (alpha1C) to non-L-type (alpha1A) Ca(2+) channel alpha1 subunits by the mutation of nine pore-associated non-conserved amino acid residues, yielding mutant alpha1A(DHP). To det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ccb40a20b5f9a12452ba5d18164a464
https://doi.org/10.1042/bj3470829

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[Untitled]

Autor: Steffen Hering, Jörg Striessnig, Hartmut Glossmann, Manfred Grabner, Heino Prinz, Jörg Mitterdorfer, Richard L. Kraus

Publikováno v: Journal of Bioenergetics and Biomembranes. 30:319-334

Different types of voltage-gated Ca2+ channels exist in the plasma membrane of electrically excitable cells. By controlling depolarization-induced Ca2+ entry into cells they serve important physiological functions, such as excitation-contraction coup

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f991b09e2a7bfb26a004b60ed6c3ee7c
https://doi.org/10.1023/a:1021933504909

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Subunit Composition of Brain Voltage-gated Potassium Channels Determined by Hongotoxin-1, a Novel Peptide Derived fromCentruroides limbatus Venom

Autor: Gregory J. Kaczorowski, Jörg Mitterdorfer, Maria L. Garcia, Hans-Günther Knaus, Randal M. Bugianesi, Alexandra Koschak

Publikováno v: Journal of Biological Chemistry. 273:2639-2644

Five novel peptidyl inhibitors of Shaker-type (Kv1) K+ channels have been purified to homogeneity from venom of the scorpion Centruroides limbatus. The complete primary amino acid sequence of the major component, hongotoxin-1 (HgTX1), has been determ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db5937347e19bd26f817986f33b5682
https://doi.org/10.1074/jbc.273.5.2639

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Nine L-type Amino Acid Residues Confer Full 1,4-Dihydropyridine Sensitivity to the Neuronal Calcium Channel α1ASubunit

Autor: Steffen Hering, Zhengyi Wang, Manfred Grabner, Hartmut Glossmann, Jörg Striessnig, Martina J. Sinnegger, Jörg Mitterdorfer

Publikováno v: Journal of Biological Chemistry. 272:27686-27693

Pharmacological modulation by 1,4-dihydropyridines is a central feature of L-type calcium channels. Recently, eight L-type amino acid residues in transmembrane segments IIIS5, IIIS6, and IVS6 of the calcium channel alpha1 subunit were identified to s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::877f709026894f2d4fbe6e3a9bd04e67
https://doi.org/10.1074/jbc.272.44.27686

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Calcium channel block by (-)devapamil is affected by the sequence environment and composition of the phenylalkylamine receptor site

Autor: Stefan Aczél, Frank Döring, Jörg Mitterdorfer, Degtiar' Ve, Steffen Hering, D. Kimball, Stanislav Berjukow, Eugen Timin

Publikováno v: Biophysical Journal. 73(1):157-167

The pore-forming alpha 1 subunit of L-type calcium (Ca2+) channels is the molecular target of Ca2+ channel blockers such as phenylalkylamines (PAAs). Association and dissociation rates of (-)devapamil were compared for a highly PAA-sensitive L-type C

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Two Amino Acid Residues in the IIIS5 Segment of L-Type Calcium Channels Differentially Contribute to 1,4-Dihydropyridine Sensitivity

Autor: Manfred Grabner, Steffen Hering, Jörg Mitterdorfer, Striessnig Jörg, Martina J. Sinnegger, Zhengyi Wang, Hartmut Glossmann

Publikováno v: Journal of Biological Chemistry. 271:30330-30335

The transmembrane segment IIIS5 of the L-type calcium channel alpha1 subunit participates in the formation of the 1,4-dihydropyridine (DHP) interaction domain (Grabner, M., Wang, Z., Hering, S., Striessnig, J., and Glossmann, H. (1996) Neuron 16, 207

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https://doi.org/10.1074/jbc.271.48.30330

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Transfer of High Sensitivity for Benzothiazepines from L-type to Class A (BI) Calcium Channels

Autor: Martina J. Sinnegger, Jörg Striessnig, Jörg Mitterdorfer, Manfred Grabner, Frank Döring, Degtiar' Ve, Stanislav Berjukow, Zhengyi Wang, Steffen Hering, Stefan Aczél, Hartmut Glossmann

Publikováno v: Journal of Biological Chemistry. 271:24471-24475

To investigate the molecular basis of the calcium channel block by diltiazem, we transferred amino acids of the highly sensitive and stereoselective L-type (alpha1S or alpha1C) to a weakly sensitive, nonstereoselective class A (alpha1A) calcium chann

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https://doi.org/10.1074/jbc.271.40.24471

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Synthesis and Biological Evaluation of 14-Alkoxymorphinans. Part 8. 14-methoxymetopon, an extremely potent opioid agonist

Autor: Helmut Schmidhammer, Jörg Mitterdorfer, Andrea Schratz

Publikováno v: Helvetica Chimica Acta. 73:1784-1787

14-Methoxymetopon (= 5,14-O-dimethyloxymorphone; 4) and 14-etoxymetopon (5) were synthesized from 14-hydroxy-5-methylcodeinone (6). In the AcOH-writhing test in mice, compound 4 was found to be ca. 20 000 times more potent than morphine

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https://doi.org/10.1002/hlca.19900730623

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