Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jörg Mitterdorfer"'
Autor:
Jörg Mitterdorfer, Bruce P. Bean
Publikováno v:
The Journal of Neuroscience. 22:10106-10115
Central neurons have multiple types of voltage-dependent potassium channels, whose activation during action potentials shapes spike width and whose activation and inactivation at subthreshold voltages modulate firing frequency. We characterized the v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6edde81b0d39f546e24229d26c02bc0
https://doi.org/10.1523/jneurosci.22-23-10106.2002
https://doi.org/10.1523/jneurosci.22-23-10106.2002
Autor:
Hartmut Glossmann, Irene G. Huber, Alexander Herzog, Edwin Wappl, Jörg Striessnig, Jörg Mitterdorfer, Thierry Langer
Publikováno v:
Biochemical Journal. 347:829-836
Sensitivity to 1,4-dihydropyridines (DHPs) can be transferred from L-type (alpha1C) to non-L-type (alpha1A) Ca(2+) channel alpha1 subunits by the mutation of nine pore-associated non-conserved amino acid residues, yielding mutant alpha1A(DHP). To det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ccb40a20b5f9a12452ba5d18164a464
https://doi.org/10.1042/bj3470829
https://doi.org/10.1042/bj3470829
Autor:
Steffen Hering, Jörg Striessnig, Hartmut Glossmann, Manfred Grabner, Heino Prinz, Jörg Mitterdorfer, Richard L. Kraus
Publikováno v:
Journal of Bioenergetics and Biomembranes. 30:319-334
Different types of voltage-gated Ca2+ channels exist in the plasma membrane of electrically excitable cells. By controlling depolarization-induced Ca2+ entry into cells they serve important physiological functions, such as excitation-contraction coup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f991b09e2a7bfb26a004b60ed6c3ee7c
https://doi.org/10.1023/a:1021933504909
https://doi.org/10.1023/a:1021933504909
Autor:
Gregory J. Kaczorowski, Jörg Mitterdorfer, Maria L. Garcia, Hans-Günther Knaus, Randal M. Bugianesi, Alexandra Koschak
Publikováno v:
Journal of Biological Chemistry. 273:2639-2644
Five novel peptidyl inhibitors of Shaker-type (Kv1) K+ channels have been purified to homogeneity from venom of the scorpion Centruroides limbatus. The complete primary amino acid sequence of the major component, hongotoxin-1 (HgTX1), has been determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db5937347e19bd26f817986f33b5682
https://doi.org/10.1074/jbc.273.5.2639
https://doi.org/10.1074/jbc.273.5.2639
Autor:
Steffen Hering, Zhengyi Wang, Manfred Grabner, Hartmut Glossmann, Jörg Striessnig, Martina J. Sinnegger, Jörg Mitterdorfer
Publikováno v:
Journal of Biological Chemistry. 272:27686-27693
Pharmacological modulation by 1,4-dihydropyridines is a central feature of L-type calcium channels. Recently, eight L-type amino acid residues in transmembrane segments IIIS5, IIIS6, and IVS6 of the calcium channel alpha1 subunit were identified to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::877f709026894f2d4fbe6e3a9bd04e67
https://doi.org/10.1074/jbc.272.44.27686
https://doi.org/10.1074/jbc.272.44.27686
Autor:
Stefan Aczél, Frank Döring, Jörg Mitterdorfer, Degtiar' Ve, Steffen Hering, D. Kimball, Stanislav Berjukow, Eugen Timin
Publikováno v:
Biophysical Journal. 73(1):157-167
The pore-forming alpha 1 subunit of L-type calcium (Ca2+) channels is the molecular target of Ca2+ channel blockers such as phenylalkylamines (PAAs). Association and dissociation rates of (-)devapamil were compared for a highly PAA-sensitive L-type C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29831668e256da5ca5499dd4decc233
Autor:
Manfred Grabner, Steffen Hering, Jörg Mitterdorfer, Striessnig Jörg, Martina J. Sinnegger, Zhengyi Wang, Hartmut Glossmann
Publikováno v:
Journal of Biological Chemistry. 271:30330-30335
The transmembrane segment IIIS5 of the L-type calcium channel alpha1 subunit participates in the formation of the 1,4-dihydropyridine (DHP) interaction domain (Grabner, M., Wang, Z., Hering, S., Striessnig, J., and Glossmann, H. (1996) Neuron 16, 207
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c519d4bf8132251a216b42c4df2824
https://doi.org/10.1074/jbc.271.48.30330
https://doi.org/10.1074/jbc.271.48.30330
Autor:
Martina J. Sinnegger, Jörg Striessnig, Jörg Mitterdorfer, Manfred Grabner, Frank Döring, Degtiar' Ve, Stanislav Berjukow, Zhengyi Wang, Steffen Hering, Stefan Aczél, Hartmut Glossmann
Publikováno v:
Journal of Biological Chemistry. 271:24471-24475
To investigate the molecular basis of the calcium channel block by diltiazem, we transferred amino acids of the highly sensitive and stereoselective L-type (alpha1S or alpha1C) to a weakly sensitive, nonstereoselective class A (alpha1A) calcium chann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cec18306e860c9d9f2a5dc7b410f56b
https://doi.org/10.1074/jbc.271.40.24471
https://doi.org/10.1074/jbc.271.40.24471
Publikováno v:
Helvetica Chimica Acta. 73:1784-1787
14-Methoxymetopon (= 5,14-O-dimethyloxymorphone; 4) and 14-etoxymetopon (5) were synthesized from 14-hydroxy-5-methylcodeinone (6). In the AcOH-writhing test in mice, compound 4 was found to be ca. 20 000 times more potent than morphine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcf4298bb60f6378bfb63aeb24e83ef4
https://doi.org/10.1002/hlca.19900730623
https://doi.org/10.1002/hlca.19900730623
Autor:
Ernst Ganglbauer, Helmut Schmidhammer, Jörg Mitterdorfer, Judith M. Rollinger, C. F. C. Smith
Publikováno v:
Helvetica Chimica Acta. 73:1779-1783
The bimorphinans 6 and 7 have been prepared from 14-O-methylnaloxone (2) and 14-O-methylnaltrexone (3), respectively. The known compounds 2 and 3 were synthesized by a different route than the route described. Bimorphinan 7 possessed a similar χ rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c75a2d21d1cebd3cfb18c150422a0124
https://doi.org/10.1002/hlca.19900730622
https://doi.org/10.1002/hlca.19900730622