Výsledky vyhledávání - "Jörg Magerkurth"

Quantitative T2, T2*, and T2′ MR imaging in patients with ischemic leukoaraiosis might detect microstructural changes and cortical hypoxia

Autor: Oliver C. Singer, Steffen Volz, Ralf Deichmann, Luciana Porto, Michael Helfrich, Jörg Magerkurth, Elke Hattingen, Marlies Wagner, Stella Blasel, Alina Jurcoane

Publikováno v: Neuroradiology. 57:1023-1030

Quantitative MRI with T2, T2*, and T2′ mapping has been shown to non-invasively depict microstructural changes (T2) and oxygenation status (T2* and T2′) that are invisible on conventional MRI. Therefore, we aimed to assess whether T2 and T2′ qu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c976d0a7ecbf90a970387f3dc5bb20d2
https://doi.org/10.1007/s00234-015-1565-x

Zobrazit plný text záznamu

T2′ Imaging Within Perfusion-Restricted Tissue in High-Grade Occlusive Carotid Disease

Autor: Marlies Wagner, Tobias Neumann-Haefelin, Oliver C. Singer, Ralf Deichmann, Alina Jurcoane, Jörg Magerkurth, Alexander Seiler, Elke Hattingen

Publikováno v: Stroke. 43:1831-1836

Background and Purpose— Quantitative T2′ imaging presumably detects regional changes in the relation of oxygenated and deoxygenated hemoglobin. Regional differences in hemoglobin oxygenation might reflect areas with increased oxygen extraction fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7e2dc1872759461d6ca5704344da94
https://doi.org/10.1161/strokeaha.111.646109

Zobrazit plný text záznamu

Autor: Ralf Deichmann, Jörg Magerkurth, Alina Jurcoane, Marlies Wagner, Oliver C. Singer, Steffen Volz, Tobias Neumann-Haefelin, Friedhelm E. Zanella, Elke Hattingen

Publikováno v: AJNR Am J Neuroradiol

BACKGROUND AND PURPOSE: Cerebral perfusion and O(2) metabolism are affected by physiologic age-related changes. High-resolution motion-corrected quantitative T2′-imaging and PASL were used to evaluate differences in deoxygenated hemoglobin and CBF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2931467992372607f8a3cb0311bf4ff
https://doi.org/10.3174/ajnr.a3138

Zobrazit plný text záznamu

GBA-associated PD Neurodegeneration, altered membrane metabolism, and lack of energy failure

Autor: Jörg Magerkurth, Kathrin Brockmann, Ulrich Pilatus, Karin Srulijes, Daniela Berg, Elke Hattingen, Thomas Gasser, Ilona Csoti, Caroline Denise Merten, Simon Baudrexel, Ruediger Hilker, Claudia Schulte, Ann-Kathrin Hauser

Publikováno v: Neurology; Vol 79
Neurology 79(3), 213-220 (2012). doi:10.1212/WNL.0b013e31825dd369
Web of Science
Neurology

Objective: To elucidate possible mechanisms leading to neurodegeneration in patients with glucocerebrosidase ( GBA )–associated Parkinson disease (PD) using combined proton ( 1 H) and phosphorus ( 31 P) magnetic resonance spectroscopic imaging (MRS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103acbdd49515aa1820585e1edd9e2f4

Zobrazit plný text záznamu

Combined 1H and 31P spectroscopy provides new insights into the pathobiochemistry of brain damage in multiple sclerosis

Autor: Ulf Ziemann, Elke Hattingen, Annemarie Hübers, Mathias Wahl, Jörg Magerkurth, Ulrich Pilatus

Publikováno v: NMR in Biomedicine. 24:536-546

(1)H MRSI has evolved as an important tool to study the onset and progression of brain damage in multiple sclerosis. Abnormal increases in total creatine, total choline and myoinositol have been noted in multiple sclerosis. However, the pathobiochemi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeef7e604efaa582a6680ec9ca985858
https://doi.org/10.1002/nbm.1621

Zobrazit plný text záznamu

Phosphorus and proton magnetic resonance spectroscopy demonstrates mitochondrial dysfunction in early and advanced Parkinson's disease

Autor: Elke Hattingen, Anne Mozer, Ulrich Pilatus, Jörg Magerkurth, Carola Seifried, Rüdiger Hilker, Helmuth Steinmetz, Friedhelm E. Zanella

Publikováno v: Brain. 132:3285-3297

Mitochondrial dysfunction hypothetically contributes to neuronal degeneration in patients with Parkinson's disease. While several in vitro data exist, the measurement of cerebral mitochondrial dysfunction in living patients with Parkinson's disease i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ed53eedc23a8166cf4ca292cd9e061
https://doi.org/10.1093/brain/awp293

Zobrazit plný text záznamu

In vivo Evidence for Cerebral Depletion in High-Energy Phosphates in Progressive Supranuclear Palsy

Autor: Jörg Magerkurth, Ulrich Pilatus, Susanne Knake, Karla Eggert, Günter U. Höglinger, Carmen Schade-Brittinger, Merle Ruberg, Alexander Reuss, Maria Stamelou, Wolfgang H. Oertel

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 29:861-870

Indirect evidence from laboratory studies suggests that mitochondrial energy metabolism is impaired in progressive supranuclear palsy (PSP), but brain energy metabolism has not yet been studied directly in vivo in a comprehensive manner in patients.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7718bdbb0a5f702e6b7e50a8d6ceb6
https://doi.org/10.1038/jcbfm.2009.2

Zobrazit plný text záznamu

Short-term effects of coenzyme Q10 in progressive supranuclear palsy: A randomized, placebo-controlled trial

Autor: Ulrich Pilatus, Alexander Reuss, Karla Eggert, Maria Stamelou, Carmen Schade-Brittinger, Petra Niklowitz, Günter U. Höglinger, Andrea Krisp, Wolfgang H. Oertel, Jörg Magerkurth, Thomas Menke

Publikováno v: Movement Disorders. 23:942-949

Mitochondrial complex I appears to be dysfunctional in progressive supranuclear palsy (PSP). Coenzyme Q(10) (CoQ(10)) is a physiological cofactor of complex I. Therefore, we evaluated the short-term effects of CoQ(10) in PSP. We performed a double-bl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7cb10b6e8ce34dad1c4203f40bdd55d4
https://doi.org/10.1002/mds.22023

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání