Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jörg Mühlisch"'
Publikováno v:
ELECTROPHORESIS. 36:2939-2950
Along with histone modifications, RNA interference and delayed replication timing, DNA methylation belongs to the key processes in epigenetic regulation of gene expression. Therefore, reliable information about the methylation level of particular DNA
Autor:
Birigit Lechtape, Martin Hasselblatt, Jörg Mühlisch, Steven C. Clifford, Michael C. Frühwald, Sabrina Schlosser, Joachim Gerss, Jonas H. Kreth, Gunther Richter, Rebekka Unland, Kornelius Kerl, Tanja Plagemann, Nicole Farwick
Publikováno v:
Journal of neuro-oncology. 116(2)
Epigenetic alterations are common events in cancer. Using a genome wide methylation screen (Restriction Landmark Genomic Scanning-RLGS) we identified the gene for the dopamine receptor D4 (DRD4) as tumor-specific methylated. As DRD4 is involved in ea
Autor:
Marcos J. Araúzo-Bravo, Jin Young Joo, Kinarm Ko, Julee Kim, Michael C. Frühwald, Natalia Tapia, Davood Sabour, Boris Greber, Jörg Mühlisch, Hans R. Schöler, Jury Francine, Guangming Wu
Publikováno v:
Stem cell reviews and reports. 8(2)
IntroductionPrimordial germ cells (PGCs) are the precursors of the maleand female gametes. At 6.25 days post coitum (dpc), PGCsare specified in the proximal epiblast [21] and then migratethrough the hindgut into the developing gonads [27]. At12.5 dpc
Publikováno v:
Analytical biochemistry. 421(2)
Methylation of DNA is a well-known epigenetic mechanism to control DNA transcription. The determination of the exact methylation level of DNA samples is of great interest due to its significant deregulation in tumor cells. Here the genome-wide DNA me
Autor:
Jörg Mühlisch, Michael C. Frühwald, Joachim Gerss, Andreas Niemann, Georg Hempel, Joachim Boos
Publikováno v:
Therapeutic drug monitoring. 32(4)
The use of intrathecal (IT) methotrexate (MTX) in combination with systemic high-dose (HD) MTX is an established procedure for central nervous system prophylaxis in patients with acute lymphoblastic leukemia, but the evidence for the necessity of thi
Autor:
Sabrina Schlosser, Jörg Mühlisch, Michael C. Frühwald, Georg Hempel, Bernhard Wünsch, Simon Goedecke
DNA methylation as an epigenetic modification of the human genome is under emphatic investigation. Several studies have demonstrated a role of DNA methylation in oncogenesis. In conjunction with histone modifications, DNA methylation may cause the fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a7079742719fa71a90c3ea31c374b1
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/73644
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/73644
Autor:
Simon Goedecke, Sabrina Schlosser, Jörg Mühlisch, Michael C. Frühwald, Bernhard Wünsch, Georg Hempel
Aberrant DNA methylation of gene promoters may be investigated by an array of different technologies. Besides DNA sequencing techniques following bisulfite treatment and determination of overall methylation by quantification of 5-methylcytosine/cytos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e6f1c294501ad2e8a82b30075e4b743
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/73647
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/73647
Autor:
Jörg Mühlisch, Sabine Wagner, Johannes E. A. Wolff, Martin Hasselblatt, Michael C. Frühwald, Sabrina Schlosser, Joachim Gerß
Publikováno v:
Pediatric Blood & Cancer.
Background Studies in adults with malignant glioma suggest MGMT methylation as a stratification marker. Similar data for children are sparse. We investigated the impact of MGMT methylation and expression on survival of children with high-grade glioma
Aberrant MGMT (O6-methylguanine-DNA methyltransferase) promoter methylation in choroid plexus tumors
Autor:
Tezer Kutluk, Ove Peters, Michael C. Frühwald, Astrid Jeibmann, Martin Hasselblatt, Birgit Kallinger, Jörg Mühlisch, Johannes E. A. Wolff, Brigitte Wrede, Werner Paulus
Aberrant methylation of the MGMT (O6-methylguanine-DNA methyltransferase) DNA-repair gene is a predictive marker for the response to chemotherapy with alkylating agents (e.g., temozolomide) in malignant gliomas. Since temozolomide is considered for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc6889d62a6ed530c064d3ac190ca950
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/73788
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/73788
Autor:
Jörg Mühlisch, G. Würthwein, Michael C. Frühwald, H Jürgens, T. Bajanowski, Wolfgang Roggendorf, Christian H. Rickert
Publikováno v:
Journal of neuro-oncology. 83(1)
Certain risk groups among tumors of the central nervous system (CNS) in children take an almost inevitably fatal course. The elucidation of molecular mechanisms offers hope for improved therapy. Aberrant methylation is common in malignant brain tumor