Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jörg Leers"'
Autor:
Andreas Herchenröther, Stefanie Gossen, Tobias Friedrich, Alexander Reim, Nadine Daus, Felix Diegmüller, Jörg Leers, Hakimeh Moghaddas Sani, Sarah Gerstner, Leah Schwarz, Inga Stellmacher, Laura Victoria Szymkowiak, Andrea Nist, Thorsten Stiewe, Tilman Borggrefe, Matthias Mann, Joel P. Mackay, Marek Bartkuhn, Annette Borchers, Jie Lan, Sandra B. Hake
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
How the histone variant H2A.Z controls cell fate remains unclear. Here, the authors reveal that the H2A.Z interacting partner HMG20A plays a key role in regulating transcription during early head and heart development.
Externí odkaz:
https://doaj.org/article/0637b8d8470142babbb8a8e3dc3bbf4c
Autor:
Andreas Herchenröther, Stefanie Gossen, Tobias Friedrich, Alexander Reim, Nadine Daus, Felix Diegmüller, Jörg Leers, Hakimeh Moghaddas Sani, Sarah Gerstner, Leah Schwarz, Inga Stellmacher, Laura Victoria Szymkowiak, Andrea Nist, Thorsten Stiewe, Tilman Borggrefe, Matthias Mann, Joel P. Mackay, Marek Bartkuhn, Annette Borchers, Jie Lan, Sandra B. Hake
/SummarySpecialized chromatin-binding proteins are required for DNA-based processes during development. We recently established PWWP2A as direct histone variant H2A.Z interactor involved in mitosis and cranial-facial development. Here, we identify th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba0e9a8f17b8bd13f1429e6199c12dc7
https://doi.org/10.1101/2022.05.04.490592
https://doi.org/10.1101/2022.05.04.490592
Publikováno v:
The Journal of Physiology. 573:413-425
Endothelial cells (ECs) from different vascular beds display certain common qualities, but each subtype is uniquely adapted to meet the demands of the underlying tissues. The structural peculiarities of intercellular junctions are, for instance, cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eabc3b8da871722af99b185d3b4e9d1
https://doi.org/10.1113/jphysiol.2006.106385
https://doi.org/10.1113/jphysiol.2006.106385
Publikováno v:
Nucleic Acids Research. 34:397-406
The Mi-2/NuRD complex is a multi-subunit protein complex with enzymatic activities involving chromatin remodeling and histone deacetylation. Targeting of Mi-2/NuRD to methylated CpG sequences mediates gene repression. The function of p66alpha and of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d21d6b004110e32106cb878a233a89d
https://doi.org/10.1093/nar/gkj437
https://doi.org/10.1093/nar/gkj437
Publikováno v:
Biochemical and Biophysical Research Communications. 335:168-174
The suppressor of cytokine signalling (SOCS) protein family negatively regulates cytokine action. In this study, we investigated the effects of estrogen (E2) on SOCS-3 expression in T47D and MCF-7 human breast cancer cells. Real-time PCR analysis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb1dd8c990e58baa7bbcd077036fb95
https://doi.org/10.1016/j.bbrc.2005.07.057
https://doi.org/10.1016/j.bbrc.2005.07.057
Differential Recruitment of the Mammalian Mediator Subunit TRAP220 by Estrogen Receptors ERα and ERβ
Publikováno v:
Journal of Biological Chemistry. 276:23397-23404
Estrogen receptors (ERs) associate with distinct transcriptional coactivators to mediate activation of target genes in response to estrogens. Previous work has provided multiple evidence for a critical role of p160 coactivators and associated histone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7480ddcb5e41e65803aa9c8c7aba6c2
https://doi.org/10.1074/jbc.m011651200
https://doi.org/10.1074/jbc.m011651200
Autor:
Anette Wärnmark, Markku Pelto-Huikko, Jörg Leers, Lotta Johansson, Giannis Spyrou, Anthony P. H. Wright, Jan-Åke Gustafsson, Maria Sjöberg, Jane S. Thomsen, Eckardt Treuter
Publikováno v:
Journal of Biological Chemistry. 274:6667-6677
Transcriptional activation by nuclear receptors (NRs) involves the concerted action of coactivators, chromatin components, and the basal transcription machinery. Crucial NR coactivators, which target primarily the conserved ligand-regulated activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67d6730ab28dc8abff1f728a72f21b53
https://doi.org/10.1074/jbc.274.10.6667
https://doi.org/10.1074/jbc.274.10.6667
Publikováno v:
Molecular and Cellular Biology. 18:6001-6013
Nuclear hormone receptors exert transcriptional activation of target genes upon hormone induction via interactions with the basal transcription machinery. This interaction is mediated by cofactors which physically bind to receptors, thereby acting as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30002f3837debf1f7a192b62bbcd42f
https://doi.org/10.1128/mcb.18.10.6001
https://doi.org/10.1128/mcb.18.10.6001
Publikováno v:
Molecular Endocrinology. 12:864-881
Transcriptional regulation of gene expression by nuclear receptors requires negatively and positively acting cofactors. Recent models for receptor activation propose that certain receptors in the absence of ligands can recruit corepressors while liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a676dec01fe4e7a42140d97434d77a3
https://doi.org/10.1210/mend.12.6.0123
https://doi.org/10.1210/mend.12.6.0123
Publikováno v:
Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology, Elsevier, 2008, 295 (1-2), pp.39. ⟨10.1016/j.mce.2008.08.011⟩
Molecular and Cellular Endocrinology, Elsevier, 2008, 295 (1-2), pp.39. ⟨10.1016/j.mce.2008.08.011⟩
The 65kDa protein occludin is an essential element of the blood-brain barrier. This integral membrane protein represents an important part of the tight junctions, which seal and protect the blood brain barrier against paracellular diffusion of solute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2aecc6c74a078675e057b746aaaf21b
https://pubmed.ncbi.nlm.nih.gov/18782596
https://pubmed.ncbi.nlm.nih.gov/18782596