Zobrazeno 1 - 10
of 203
pro vyhledávání: '"Jörg Langowski"'
Autor:
Alexander Gansen, Suren Felekyan, Ralf Kühnemuth, Kathrin Lehmann, Katalin Tóth, Claus A. M. Seidel, Jörg Langowski
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nucleosomes compact the genome and regulate access to specific DNA sequences. Here the authors employ single-molecule FRET studies to characterize nucleosome dynamics at different salt concentrations and dissect nucleosome disassembly into elementary
Externí odkaz:
https://doaj.org/article/027c6235d43c47e7b8c91fcf0e44bef1
Autor:
Paul Victor Sauer, Jennifer Timm, Danni Liu, David Sitbon, Elisabetta Boeri-Erba, Christophe Velours, Norbert Mücke, Jörg Langowski, Françoise Ochsenbein, Geneviève Almouzni, Daniel Panne
Publikováno v:
eLife, Vol 6 (2017)
How the very first step in nucleosome assembly, deposition of histone H3-H4 as tetramers or dimers on DNA, is accomplished remains largely unclear. Here, we report that yeast chromatin assembly factor 1 (CAF1), a conserved histone chaperone complex t
Externí odkaz:
https://doaj.org/article/13159998535b4ce984485d81f26c20d9
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157451 (2016)
Intermediate filament (IF) elongation proceeds via full-width "mini-filaments", referred to as "unit-length" filaments (ULFs), which instantaneously form by lateral association of extended coiled-coil complexes after assembly is initiated. In a compa
Externí odkaz:
https://doaj.org/article/e703af79af67463c8d10897368918fa4
Autor:
Agata Pernuš, Jörg Langowski
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123070 (2015)
We collected mobility and interaction maps of c-Fos-eGFP and c-Jun-mRFP1 transcription factors within living cell nuclei. c-Fos dimerizes with c-Jun to form the transcription activator protein-1 (AP-1) which binds to the specific recognition site. To
Externí odkaz:
https://doaj.org/article/977bd2920d954e37982ed1aa14074700
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e57018 (2013)
Nucleosome structure and stability affect genetic accessibility by altering the local chromatin morphology. Recent FRET experiments on nucleosomes have given valuable insight into the structural transformations they can adopt. Yet, even if performed
Externí odkaz:
https://doaj.org/article/69f33354955b446789c99e5e94058708
Autor:
Ronan Broderick, Sivaramakrishnan Ramadurai, Katalin Tóth, Denisio M Togashi, Alan G Ryder, Jörg Langowski, Heinz Peter Nasheuer
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35537 (2012)
Eukaryotic DNA replication is a dynamic process requiring the co-operation of specific replication proteins. We measured the mobility of eGFP-Cdc45 by Fluorescence Correlation Spectroscopy (FCS) in vivo in asynchronous cells and in cells synchronized
Externí odkaz:
https://doaj.org/article/047d8be4478e45f3a39ad306bcde3cf1
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 12, p e1002279 (2011)
Histone tails play an important role in nucleosome structure and dynamics. Here we investigate the effect of truncation of histone tails H3, H4, H2A and H2B on nucleosome structure with 100 ns all-atom molecular dynamics simulations. Tail domains of
Externí odkaz:
https://doaj.org/article/ee750a33b4684ddda8f786a138b457b0
Autor:
Thomas Kühn, Teemu O Ihalainen, Jari Hyväluoma, Nicolas Dross, Sami F Willman, Jörg Langowski, Maija Vihinen-Ranta, Jussi Timonen
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22962 (2011)
We introduce a new method for mesoscopic modeling of protein diffusion in an entire cell. This method is based on the construction of a three-dimensional digital model cell from confocal microscopy data. The model cell is segmented into the cytoplasm
Externí odkaz:
https://doaj.org/article/45966f16aa314dd2919ac0b530383fa0
Autor:
Stefan Winheim, Aaron R Hieb, Marleen Silbermann, Eva-Maria Surmann, Tatjana Wedig, Harald Herrmann, Jörg Langowski, Norbert Mücke
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19202 (2011)
Quantitative imaging of intermediate filaments (IF) during the advanced phase of the assembly process is technically difficult, since the structures are several µm long and therefore they exceed the field of view of many electron (EM) or atomic forc
Externí odkaz:
https://doaj.org/article/6bf790fe48e94ba9a6d7fe7c2cc74930
Autor:
Norbert Mücke, Konstantin Klenin, Robert Kirmse, Malte Bussiek, Harald Herrmann, Mathias Hafner, Jörg Langowski
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7756 (2009)
Nanomechanical properties of filamentous biopolymers, such as the persistence length, may be determined from two-dimensional images of molecules immobilized on surfaces. For a single filament in solution, two principal adsorption scenarios are possib
Externí odkaz:
https://doaj.org/article/8e96228e05f9465b82dc5366264c7ca2