Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Jörg Kumbrink"'
Molecular characterization of the evolution of premalignant lesions in the upper aerodigestive tract
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionEarly relapse and development of metastatic disease are some of the primary reasons for the poor prognosis of patients with head and neck squamous cell carcinoma (HNSCC). HNSCC is a heterogeneous disease which may develop in large premali
Externí odkaz:
https://doaj.org/article/0f4d5ded44514cd896064cd9c1d68777
Autor:
Jörg Kumbrink, Melanie-Christin Demes, Jan Jeroch, Andreas Bräuninger, Kristin Hartung, Uwe Gerstenmaier, Ralf Marienfeld, Axel Hillmer, Nadine Bohn, Christina Lehning, Ferdinand Ferch, Peter Wild, Stefan Gattenlöhner, Peter Möller, Frederick Klauschen, Andreas Jung
Publikováno v:
Pathology and Oncology Research, Vol 30 (2024)
Lung cancer is a paradigm for a genetically driven tumor. A variety of drugs were developed targeting specific biomarkers requiring testing for tumor genetic alterations in relevant biomarkers. Different next-generation sequencing technologies are av
Externí odkaz:
https://doaj.org/article/4cb60bd82d3c4b56863f874dcfbdde4b
Autor:
Stefanie Jaitner, Elise Pretzsch, Jens Neumann, Achim Schäffauer, Matthias Schiemann, Martin Angele, Jörg Kumbrink, Sarah Schwitalla, Florian R Greten, Lydia Brandl, Frederick Klauschen, David Horst, Thomas Kirchner, Andreas Jung
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 1, Pp 73-85 (2023)
Abstract Tumor stem cells play a pivotal role in carcinogenesis and metastatic spread in colorectal cancer (CRC). Olfactomedin 4 (OLFM4) is co‐expressed with the established stem cell marker leucine‐rich repeat‐containing G protein‐coupled re
Externí odkaz:
https://doaj.org/article/d903398b384143ad97cc9d24b0b76ede
Autor:
Fabian B. T. Kraus, Elena Sultova, Kathrin Heinrich, Andreas Jung, C. Benedikt Westphalen, Christina V. Tauber, Jörg Kumbrink, Martina Rudelius, Frederick Klauschen, Philipp A. Greif, Alexander König, Anca Chelariu-Raicu, Bastian Czogalla, Alexander Burges, Sven Mahner, Rachel Wuerstlein, Fabian Trillsch
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2345 (2024)
Advances in molecular tumor diagnostics have transformed cancer care. However, it remains unclear whether precision oncology has the same impact and transformative nature across all malignancies. We conducted a retrospective analysis of patients with
Externí odkaz:
https://doaj.org/article/bef91cea36b9475bbf8817dfe82ed9cb
Autor:
Sophie L. Boos, Leon P. Loevenich, Sebastian Vosberg, Thomas Engleitner, Rupert Öllinger, Jörg Kumbrink, Matjaz Rokavec, Marlies Michl, Philipp A. Greif, Andreas Jung, Heiko Hermeking, Jens Neumann, Thomas Kirchner, Roland Rad, Peter Jung
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 517-540 (2022)
Background & Aims: Patient-derived tumor organoids recapitulate the characteristics of colorectal cancer (CRC) and provide an ideal platform for preclinical evaluation of personalized treatment options. We aimed to model the acquisition of chemotoler
Externí odkaz:
https://doaj.org/article/916bf465e7144cfd8d6002ff3bbfa24f
Autor:
Sven Jacob, Florian Bösch, Markus B. Schoenberg, Elise Pretzsch, Christopher Lampert, Ren Haoyu, Bernhard W. Renz, Marlies Michl, Jörg Kumbrink, Thomas Kirchner, Jens Werner, Martin K. Angele, Jens Neumann
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)
Abstract Background Molecular differences in colorectal cancer (CRC) are associated with the metastatic route. Patient survival is mainly driven by metastatic spread thus it is imperative to understand its key drivers to develop biomarkers for risk s
Externí odkaz:
https://doaj.org/article/80c7cc8532c74acdb1342db764e9e655
Autor:
Deepak Vangala, Swetlana Ladigan, Sven T. Liffers, Soha Noseir, Abdelouahid Maghnouj, Tina-Maria Götze, Berlinda Verdoodt, Susanne Klein-Scory, Laura Godfrey, Martina K. Zowada, Mario Huerta, Daniel L. Edelstein, Jaime Martinez de Villarreal, Miriam Marqués, Jörg Kumbrink, Andreas Jung, Tobias Schiergens, Jens Werner, Volker Heinemann, Sebastian Stintzing, Doris Lindoerfer, Ulrich Mansmann, Michael Pohl, Christian Teschendorf, Christiane Bernhardt, Heiner Wolters, Josef Stern, Selami Usta, Richard Viebahn, Jacob Admard, Nicolas Casadei, Stefan Fröhling, Claudia R. Ball, Jens T. Siveke, Hanno Glimm, Andrea Tannapfel, Wolff Schmiegel, Stephan A. Hahn
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-25 (2021)
Abstract Background The development of secondary resistance (SR) in metastatic colorectal cancer (mCRC) treated with anti-epidermal growth factor receptor (anti-EGFR) antibodies is not fully understood at the molecular level. Here we tested in vivo s
Externí odkaz:
https://doaj.org/article/cfb1d471a175414a977bd791dd7bb74a
Autor:
Laura Sellmer, Julia Kovács, Julia Walter, Jörg Kumbrink, Jens Neumann, Diego Kauffmann-Guerrero, Rosemarie Kiefl, Christian Schneider, Andreas Jung, Jürgen Behr, Amanda Tufman
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundTumor tissue as well as regional lymph nodes are removed during curative surgery for early-stage non-small cell lung cancer (NSCLC). These tissues provide a unique snapshot of the immune cell composition at the time of surgery. We investiga
Externí odkaz:
https://doaj.org/article/4509d22af6eb4d4e9c8420a2608193b8
Autor:
Carina Heydt, Christina B. Wölwer, Oscar Velazquez Camacho, Svenja Wagener-Ryczek, Roberto Pappesch, Janna Siemanowski, Jan Rehker, Florian Haller, Abbas Agaimy, Karl Worm, Thomas Herold, Nicole Pfarr, Wilko Weichert, Thomas Kirchner, Andreas Jung, Jörg Kumbrink, Wolfgang Goering, Irene Esposito, Reinhard Buettner, Axel M. Hillmer, Sabine Merkelbach-Bruse
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-14 (2021)
Abstract Background Gene fusions represent promising targets for cancer therapy in lung cancer. Reliable detection of multiple gene fusions is therefore essential. Methods Five commercially available parallel sequencing assays were evaluated for thei
Externí odkaz:
https://doaj.org/article/44bdb1f0d72743ee9374126053306f77
Autor:
Jörg Kumbrink, Lisa Bohlmann, Soulafa Mamlouk, Torben Redmer, Daniela Peilstöcker, Pan Li, Sylvie Lorenzen, Hana Algül, Stefan Kasper, Dirk Hempel, Florian Kaiser, Marlies Michl, Harald Bartsch, Jens Neumann, Frederick Klauschen, Michael von Bergwelt-Baildon, Dominik Paul Modest, Arndt Stahler, Sebastian Stintzing, Andreas Jung, Thomas Kirchner, Reinhold Schäfer, Volker Heinemann, Julian W. Holch
Publikováno v:
Cancers, Vol 14, Iss 15, p 3631 (2022)
Most metastatic colorectal cancer (mCRC) patients succumb to refractory disease due to secondary chemotherapy resistance. To elucidate the molecular changes associated with secondary resistance, we recruited 64 patients with mCRC and hepatic metastas
Externí odkaz:
https://doaj.org/article/ac551b05f43141138488488ec5ebd79f