Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jörg Knapp"'
Publikováno v:
Journal of Cardiovascular Pharmacology. 48:820-826
Transgenic mice are often used to study the physiologic role of a known gene. The design of experiments with transgenic mice usually does not take into account strain and sex differences, at least in isolated vessels. Therefore, we have compared the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec96eb48f9f60c1369bfab4e649f9ed9
https://doi.org/10.1097/01.fjc.0000232062.80084.4f
https://doi.org/10.1097/01.fjc.0000232062.80084.4f
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 366:562-569
Smooth muscle contraction is primarily regulated by reversible phosphorylation of the 20-kDa light chains of myosin (MLC(20)) involving Ca(2+)-calmodulin-dependent myosin light chain kinase (MLCK) and serine/threonine protein phosphatases (PP). The a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cdb1060004b82a6499b5fb68368aef9
https://doi.org/10.1007/s00210-002-0635-x
https://doi.org/10.1007/s00210-002-0635-x
Activation and inactivation of cAMP-response element-mediated gene transcription in cardiac myocytes
Autor:
Joachim Neumann, Bettina Linck, Jörg Knapp, Wilhelm Schmitz, Frank U. Müller, Peter Boknik, Hartmut Lüss
Publikováno v:
Cardiovascular Research. 52:95-102
Objective: Chronic β-adrenergic stimulation of the cAMP-dependent signalling pathway is implicated in functionally relevant expressional changes in congestive heart failure. We studied activation and inactivation of the cardiac gene transcription me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7eb982e00f246800fc00625b014b48
https://doi.org/10.1016/s0008-6363(01)00361-3
https://doi.org/10.1016/s0008-6363(01)00361-3
Autor:
Otto-Erich Brodde, Joachim Neumann, Peter Boknik, Thorsten Müller, Ingrid Heinroth-Hoffmann, Hartmut Lüss, Uwe Kirchhefer, Wilhelm Schmitz, Bettina Linck, Jörg Knapp
Publikováno v:
Cardiovascular Research. 51:717-728
Objective: Chronic pressure overload in spontaneously hypertensive rats (SHR) is accompanied by heart hypertrophy and signs of heart failure. Since there is growing evidence for a possible pathophysiological role of altered protein phosphorylation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67defdbcff8917ae917922633d43bb9b
https://doi.org/10.1016/s0008-6363(01)00346-7
https://doi.org/10.1016/s0008-6363(01)00346-7
Autor:
Bettina Linck, Jörg Knapp, Hartmut Lüss, Frank U. Müller, Kunimi Kikuchi, Wilhelm Schmitz, Joachim Neumann, Ken Nomoto, Peter Boknik
Publikováno v:
Molecular and Cellular Biochemistry. 223:123-129
The aim of this study was to investigate the functional properties of the promoter of the protein phosphatase 1α catalytic subunit. Luciferase plasmids with different fragments of the rat catalytic subunit of the protein phosphatase 1α promoter ran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::422aa55d035b1114c29ab7e360c31c58
https://doi.org/10.1023/a:1017926713989
https://doi.org/10.1023/a:1017926713989
Autor:
Sabine Huke, Hartmut Lüss, Wilhelm Schmitz, Iva Lüss, Bettina Linck, F.U. Müller, Jörg Knapp, Ute Vahlensieck, Joachim Neumann, Peter Nacke, Oliver Klein-Wiele, Mario C. Deng, H. H. Scheld, Peter Boknik
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 360:464-472
It is unknown whether protein phosphatases types 1 and 2A are present in and can regulate the tone of human vascular tissue. The expression and possible function of serine/threonine protein phosphatases (PP) type 1 (PP1) and type 2A (PP2A) were studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36781136f43bf9be74784d3d0319b36a
https://doi.org/10.1007/s002109900124
https://doi.org/10.1007/s002109900124
Autor:
Uwe Kirchhefer, Joachim Neumann, Peter Boknik, Wilhelm Schmitz, Ute Vahlensieck, Larry R. Jones, Bettina Linck, Frank U. Müller, Jörg Knapp, Ulrich Kleideiter, Claus Unkel, Oliver Klein-Wiele, Norbert Zimmermann, Hartmut Lüss
Publikováno v:
Cardiovascular Research. 43:67-76
Background: Several independent lines of evidence indicate that phospholamban (PLB) expression correlates positively with depression of force of contraction and duration of contraction in isolated cardiac preparations of several animal species. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6774db3e96718ee0a8cd0b677f2f098
https://doi.org/10.1016/s0008-6363(99)00053-x
https://doi.org/10.1016/s0008-6363(99)00053-x
Autor:
Wilhelm Schmitz, Joachim Neumann, Ute Vahlensieck, Peter Boknik, Hartmut Lüss, Frank U. Müller, Hans-Gerd Gumbinger, Bettina Linck, Jörg Knapp
Publikováno v:
Journal of Chromatographic Science. 37:145-149
A rapid and simple reversed-phase high-performance liquid chromatographic (HPLC) method for the determination of clobazam concentrations in human blood samples is developed and validated. Solid-phase column extraction is performed to clean up blood s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d79dbbfd32a6971fce80fb27ddff4a
https://doi.org/10.1093/chromsci/37.5.145
https://doi.org/10.1093/chromsci/37.5.145
Autor:
H. Van Aken, Hartmut Schlüter, A. Meissner, Wilhelm Schmitz, Jörg Knapp, Hartmut Lüss, Joachim Neumann, F.U. Müller, I. Gombosova, Walter Zidek, Ute Vahlensieck, Norbert Rolf, Peter Boknik
Publikováno v:
Journal of Cardiovascular Pharmacology. 33:151-156
We studied the effects of diadenosine tetraphosphate (AP4A) on the force of contraction in canine preparations. The force of contraction was measured in isolated electrically driven (1 Hz) atrial and ventricular cardiac trabeculae from adult dogs. AP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56ed1d293f1006047456f04d349a9d8
https://doi.org/10.1097/00005344-199901000-00023
https://doi.org/10.1097/00005344-199901000-00023
Autor:
Peter Boknik, Peter Nacke, I. Gombosova, Sabine Huke, Ute Vahlensieck, Hartmut Lüss, Wilhelm Schmitz, Bettina Linck, Jörg Knapp, Thorsten Müller, Joachim Neumann, Frank U. Müller
Publikováno v:
General Pharmacology: The Vascular System. 31:729-733
1. Cantharidin is a natural defensive toxicant produced by blister beetles. 2. Cantharidin shares structural similarity with highly toxic commercial herbicides (e.g., endothall, endothall anhydride and endothall thioanhydride). 3. Cantharidin inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2c4a7020b5fc1b9d04f52d77d664c3
https://doi.org/10.1016/s0306-3623(98)00053-6
https://doi.org/10.1016/s0306-3623(98)00053-6