Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jörg Kley"'
Autor:
Daniel Grabowski, Jörg Kley, Daniel Bischoff, Danielle M. Fowler, Robert Ries, Sarah Chandler, Carola Kleiner, John Broadwater, Martin Winter, Christina Bartlett, Ralph Binetti, Sven Thamm, Andreas H. Luippold, Tom Bretschneider, Frank H. Büttner
Publikováno v:
SLAS discovery : advancing life sciences RD. 24(7)
Microbial-dependent trimethylamine (TMA) generation from dietary precursors such as choline was recently linked to cardiovascular diseases (CVDs) as well as chronic kidney disease (CKD). Inhibition of TMA-generating enzymes in gut bacteria would be a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f4401d7f3d5f2d3a59aa91a2b60df6
https://pubmed.ncbi.nlm.nih.gov/31059309
https://pubmed.ncbi.nlm.nih.gov/31059309
Autor:
Thorsten Lehmann, Ralf Lotz, Thorsten Oost, Mueller Stephan Georg, Klaus Rudolf, Dirk Stenkamp, Armin Heckel, Ralph Budzinski, Jörg Kley, Gerd-Michael Maier, Gerald Juergen Roth, Leo Thomas, Martin Lenter, Kirsten Arndt, Michael Markert
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(16)
Although overweight and obesity are highly prevalent conditions, options to treat them are still very limited. As part of our search for safe and effective MCH-R1 antagonists for the treatment of obesity, two series of pyridones and pyridazinones wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91aeff56d7e815683ba2afe39561cfc7
https://pubmed.ncbi.nlm.nih.gov/26105194
https://pubmed.ncbi.nlm.nih.gov/26105194
Autor:
Gerd-Michael Maier, Thorsten Lehmann, Ralf Lotz, Jörg Kley, Martin Lenter, Michael Markert, Mueller Stephan Georg, Kirsten Arndt, Philipp Lustenberger, Klaus Rudolf, Thorsten Oost, Armin Heckel, Marcus Schindler, Gerald Juergen Roth, Dirk Stenkamp
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(16)
Despite recent approvals of anti-obesity drugs there is still a high therapeutic need for alternative options with higher efficacy in humans. As part of our MCH-R1 antagonist program for the treatment of obesity, a series of biphenylacetamide HTS hit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa1c429b6b312f875d5eaae07087eee
https://pubmed.ncbi.nlm.nih.gov/26112443
https://pubmed.ncbi.nlm.nih.gov/26112443
Autor:
Kirsten Arndt, Ralf Lotz, Klaus Rudolf, Thorsten Lehmann, Mueller Stephan Georg, Ralph Budzinski, Gerald Juergen Roth, Leo Thomas, Martin Lenter, Dirk Stenkamp, Armin Heckel, Thorsten Oost, Marcus Schindler, Jörg Kley
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(16)
Despite recent success there remains a high therapeutic need for the development of drugs targeting diseases associated with the metabolic syndrome. As part of our search for safe and effective MCH-R1 antagonists for the treatment of obesity, a serie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f0c990c1fa596f4574b57cdd52b38e
https://pubmed.ncbi.nlm.nih.gov/26077492
https://pubmed.ncbi.nlm.nih.gov/26077492
Autor:
Gerd Siemeister, Clemens Unger, Petra Benzinger, Ulrich Massing, Jörg Kley, Georg Martiny-Baron, Petra Reusch, Dieter Marmé
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1466(1-2):71-78
Immunoliposomes (IL) containing anti-angiogenic drugs directed selectively to the easily accessible kinase insert domain containing receptor (KDR) vascular endothelial growth factor (VEGF), which is predominantly expressed on tumour vessels are a pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccffbfcaa3c696981c7542d78c0d33df
Publikováno v:
Monatshefte für Chemie / Chemical Monthly. 129:173-185
We describe a high yield reaction sequence for the conversion of long chain alcohols into 3-(trimethylammonio)propylphosphonates. The products are phospholipase D stable isosteric phosphono analogs of the respective alkylphosphocholines. The key step
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4d7ca8d9c21f38672b934fd563537b6
https://doi.org/10.1007/pl00010153
https://doi.org/10.1007/pl00010153
Publikováno v:
ChemInform. 29
The synthesis of a series of coupling lipids designed for covalently linking proteins to liposomes is described. The new compounds have in common a cholesterylsuccinyl unit as a lipid anchor and a thiol-reactive maleimidobenzoyl unit which are linked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a51aa4592beaa5ef2413ee3190cb4cfd
https://doi.org/10.1002/chin.199827287
https://doi.org/10.1002/chin.199827287
Publikováno v:
Chemistry and Physics of Lipids. 105:189-191
A simple synthesis of N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl sulfate (DOTAP) and its analogs differing in the fatty acids is presented. The synthesis is designed as quasi-one-pot reaction and the precipitating products are purif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74325859d4a29e3ef86944cfca25d025
https://doi.org/10.1016/s0009-3084(00)00121-3
https://doi.org/10.1016/s0009-3084(00)00121-3
Autor:
Thorsten Lehmann-Lintz, Gerald Juergen Roth, Ralf Lotz, Armin Heckel, Rainer Walter, Florian Colbatzky, Jörg Kley, Ulrike Tontsch-Grunt, Frank Hilberg, Sandra Handschuh
Publikováno v:
Journal of medicinal chemistry. 52(14)
Inhibition of tumor angiogenesis through blockade of the vascular endothelial growth factor (VEGF) signaling pathway is a new treatment modality in oncology. Preclinical findings suggest that blockade of additional pro-angiogenic kinases, such as fib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbca65e5f8bd30b38cb03fd2738c9611
https://pubmed.ncbi.nlm.nih.gov/19522465
https://pubmed.ncbi.nlm.nih.gov/19522465
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(2)
Acylamino inhibitors of 14 kDa-PLA2 were synthesized which differ in the moiety that is not bound into the enzyme's active site but immersed in the lipid aggregate when a ternary inhibitory complex is formed. Our results indicate that this part of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab18ae4f632593f8ab6586a4deaa15d
https://pubmed.ncbi.nlm.nih.gov/10021941
https://pubmed.ncbi.nlm.nih.gov/10021941