Zobrazeno 1 - 10
of 431
pro vyhledávání: '"Jörg J, Goronzy"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Immune memory is a requisite and remarkable property of the immune system and is the biological foundation of the success of vaccinations in reducing morbidity from infectious diseases. Some vaccines and infections induce long-lasting protection, but
Externí odkaz:
https://doaj.org/article/5f8e44d3ffef48eabe0db9641ae1be85
Autor:
Wenqiang Cao, Ines Sturmlechner, Huimin Zhang, Jun Jin, Bin Hu, Rohit R. Jadhav, Fengqin Fang, Cornelia M. Weyand, Jörg J. Goronzy
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112195- (2023)
Summary: Naive CD4+ T cells are more resistant to age-related loss than naive CD8+ T cells, suggesting mechanisms that preferentially protect naive CD4+ T cells during aging. Here, we show that TRIB2 is more abundant in naive CD4+ than CD8+ T cells a
Externí odkaz:
https://doaj.org/article/ecfd1197fa604b269269d40f24f8721e
Publikováno v:
Immunity & Ageing, Vol 18, Iss 1, Pp 1-9 (2021)
Abstract MicroRNAs (miRNAs) are regulatory noncoding RNAs important for many aspects of cellular processes including cell differentiation and proliferation. Functions of numerous miRNAs have been identified in T cells, with miR-181a regulating T cell
Externí odkaz:
https://doaj.org/article/dd787b5dcc1347109dff3106b848ff2f
Autor:
Fengqin Fang, Wenqiang Cao, Yunmei Mu, Hirohisa Okuyama, Lingjie Li, Jingtao Qiu, Cornelia M. Weyand, Jörg J. Goronzy
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
The ectonucleotidase CD39 functions as a checkpoint in purinergic signaling on effector T cells. By depleting eATP and initiating the generation of adenosine, it impairs memory cell development and contributes to T cell exhaustion, thereby causing de
Externí odkaz:
https://doaj.org/article/9d5e1c41942241ca89dad326c17def65
Autor:
Zhongde Ye, Yi Shen, Ke Jin, Jingtao Qiu, Bin Hu, Rohit R. Jadhav, Khushboo Sheth, Cornelia M. Weyand, Jörg J. Goronzy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
ORAI3 is part of pore forming calcium channels involved in T cell activation. Here the authors show that there is increased expression of ORAI3 in T cells from patients with rheumatoid arthritis and that the transcription factor IKAROS negatively reg
Externí odkaz:
https://doaj.org/article/1194013638654e75b64350cd53e610e5
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-9 (2021)
Abstract MicroRNAs play an important role in the regulation of T cell development, activation, and differentiation. One of the most abundant microRNAs in lymphocytes is miR-181a, which controls T cell receptor (TCR) activation thresholds in thymic se
Externí odkaz:
https://doaj.org/article/08e6f57628f742cbbf6c188b84d4f6a7
Autor:
Bin Hu, Rohit R. Jadhav, Claire E. Gustafson, Sabine Le Saux, Zhongde Ye, Xuanying Li, Lu Tian, Cornelia M. Weyand, Jörg J. Goronzy
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/1ffebb6d2fb24fafa2db95ebc9619d17
Autor:
Rohit R. Jadhav, Bin Hu, Zhongde Ye, Khushboo Sheth, Xuanying Li, William J. Greenleaf, Cornelia M. Weyand, Jörg J. Goronzy
Publikováno v:
EBioMedicine, Vol 76, Iss , Pp 103825- (2022)
Summary: Background: Rheumatoid arthritis (RA) is an inflammatory disease that manifests as a preclinical stage of systemic autoimmunity followed by chronic progressive synovitis. Disease-associated genetic SNP variants predominantly map to non-codin
Externí odkaz:
https://doaj.org/article/9ef57889fd484af4ab84ef130e9839ea
Autor:
Ke Jin, Simon Parreau, Kenneth J. Warrington, Matthew J. Koster, Gerald J. Berry, Jörg J. Goronzy, Cornelia M. Weyand
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Blood vessels are indispensable for host survival and are protected from inappropriate inflammation by immune privilege. This protection is lost in patients with autoimmune vasculitides, a heterogeneous group of diseases causing damage to arteries, a
Externí odkaz:
https://doaj.org/article/d91110e59a8c404d85ef428bdabfd561
Autor:
Mitsuhiro Akiyama, Shozo Ohtsuki, Gerald J. Berry, David H. Liang, Jörg J. Goronzy, Cornelia M. Weyand
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Autoimmune diseases can afflict every organ system, including blood vessels that are critically important for host survival. The most frequent autoimmune vasculitis is giant cell arteritis (GCA), which causes aggressive wall inflammation in medium an
Externí odkaz:
https://doaj.org/article/f136914fbfff452a832614a824841226