Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Jörg Hackermüller"'
Autor:
Alix Sarah Aldehoff, Isabel Karkossa, Cornelius Goerdeler, Laura Krieg, Jana Schor, Beatrice Engelmann, Martin Wabitsch, Kathrin Landgraf, Jörg Hackermüller, Antje Körner, Ulrike Rolle-Kampczyk, Kristin Schubert, Martin von Bergen
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109711- (2024)
Summary: Obesity, characterized by enlarged and dysfunctional adipose tissue, is among today’s most pressing global public health challenges with continuously increasing prevalence. Despite the importance of post-translational protein modifications
Externí odkaz:
https://doaj.org/article/7702ef37b15f4db7bf881551156e22f8
Autor:
Lena Kramer, Tobias Schulze, Nils Klüver, Rolf Altenburger, Jörg Hackermüller, Martin Krauss, Wibke Busch
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-14 (2024)
Abstract Chemicals in the aquatic environment can be harmful to organisms and ecosystems. Knowledge on effect concentrations as well as on mechanisms and modes of interaction with biological molecules and signaling pathways is necessary to perform ch
Externí odkaz:
https://doaj.org/article/104a415af6cd43dfb523787c733092a3
Autor:
Madalena Carido, Manuela Völkner, Lisa Maria Steinheuer, Felix Wagner, Thomas Kurth, Natalie Dumler, Selen Ulusoy, Stephanie Wieneke, Anabel Villanueva Norniella, Cristina Golfieri, Shahryar Khattak, Bruno Schönfelder, Maria Scamozzi, Katja Zoschke, Sebastian Canzler, Jörg Hackermüller, Marius Ader, Mike O. Karl
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
The possible applications for human retinal organoids (HROs) derived from human induced pluripotent stem cells (hiPSC) rely on the robustness and transferability of the methodology for their generation. Standardized strategies and parameters to effec
Externí odkaz:
https://doaj.org/article/11c92076dd06422d8dbd23b2ba307247
Autor:
Liza-Marie Beckers, Rolf Altenburger, Werner Brack, Beate I. Escher, Jörg Hackermüller, Enken Hassold, Gianina Illing, Martin Krauss, Janet Krüger, Paul Michaelis, Andreas Schüttler, Sarah Stevens, Wibke Busch
Publikováno v:
Environment International, Vol 179, Iss , Pp 108155- (2023)
Aquatic environments are polluted with a multitude of organic micropollutants, which challenges risk assessment due the complexity and diversity of pollutant mixtures. The recognition that certain source-specific background pollution occurs ubiquitou
Externí odkaz:
https://doaj.org/article/dd8f4103b9d84f57b61d532386432786
Autor:
Manuela Völkner, Felix Wagner, Lisa Maria Steinheuer, Madalena Carido, Thomas Kurth, Ali Yazbeck, Jana Schor, Stephanie Wieneke, Lynn J. A. Ebner, Claudia Del Toro Runzer, David Taborsky, Katja Zoschke, Marlen Vogt, Sebastian Canzler, Andreas Hermann, Shahryar Khattak, Jörg Hackermüller, Mike O. Karl
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Complex neuropathologies, like macular degeneration, are common but incompletely understood. Here the authors report a complex human retina pathology organoid model induced by HBEGF-TNF, causing PIEZO1-mediated photoreceptor degeneration by cell extr
Externí odkaz:
https://doaj.org/article/30a2670f9c1c4f9abedd9ae8b2421fed
Autor:
Zhipeng Wang, Sven-Bastiaan Haange, Volker Haake, Maike Huisinga, Hennicke Kamp, Roland Buesen, Kristin Schubert, Sebastian Canzler, Jörg Hackermüller, Ulrike Rolle-Kampczyk, Martin von Bergen
Publikováno v:
Metabolites, Vol 13, Iss 7, p 847 (2023)
The thyroid hormones (THs) regulate various physiological mechanisms in mammals, such as cellular metabolism, cell structure, and membrane transport. The therapeutic drugs propylthiouracil (PTU) and phenytoin are known to induce hypothyroidism and de
Externí odkaz:
https://doaj.org/article/ec95621e8a1140688da4142d76ca9f2c
Autor:
Sebastian Canzler, Jörg Hackermüller
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Background Gaining biological insights into molecular responses to treatments or diseases from omics data can be accomplished by gene set or pathway enrichment methods. A plethora of different tools and algorithms have been developed so far.
Externí odkaz:
https://doaj.org/article/b71fa2ef0f3b4c2baf8f74dc7ab46d90
Autor:
Christoph Kämpf, Michael Specht, Alexander Scholz, Sven-Holger Puppel, Gero Doose, Kristin Reiche, Jana Schor, Jörg Hackermüller
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-9 (2019)
Abstract Background A lack of reproducibility has been repeatedly criticized in computational research. High throughput sequencing (HTS) data analysis is a complex multi-step process. For most of the steps a range of bioinformatic tools is available
Externí odkaz:
https://doaj.org/article/410214fa2db943e9b00596e0c1bbe4a4
Autor:
Kristin Schubert, Isabel Karkossa, Jana Schor, Beatrice Engelmann, Lisa Maria Steinheuer, Tony Bruns, Ulrike Rolle-Kampczyk, Jörg Hackermüller, Martin von Bergen
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The function of mucosal-associated invariant T (MAIT) cells highly depends on the mode of activation, either by recognition of bacterial metabolites via their T cell receptor (TCR) or in a TCR-independent manner via cytokines. The underlying molecula
Externí odkaz:
https://doaj.org/article/dac6df5a7f964b1fbea9f39c1ac6c9c9
Autor:
Polina Drozdova, Lorena Rivarola-Duarte, Daria Bedulina, Denis Axenov-Gribanov, Stephan Schreiber, Anton Gurkov, Zhanna Shatilina, Kseniya Vereshchagina, Yulia Lubyaga, Ekaterina Madyarova, Christian Otto, Frank Jühling, Wibke Busch, Lena Jakob, Magnus Lucassen, Franz Josef Sartoris, Jörg Hackermüller, Steve Hoffmann, Hans-Otto Pörtner, Till Luckenbach, Maxim Timofeyev, Peter F. Stadler
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Background Lake Baikal is one of the oldest freshwater lakes and has constituted a stable environment for millions of years, in stark contrast to small, transient bodies of water in its immediate vicinity. A highly diverse endemic endemic am
Externí odkaz:
https://doaj.org/article/0e2ee3df4e7647439bfe41440ecef3a1