Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Jörg Felsberg"'
Droplet digital PCR-based analyses for robust, rapid, and sensitive molecular diagnostics of gliomas
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-19 (2022)
Abstract Classification of gliomas involves the combination of histological features with molecular biomarkers to establish an integrated histomolecular diagnosis. Here, we report on the application and validation of a set of molecular assays for gli
Externí odkaz:
https://doaj.org/article/9394523355074114940ed5670e175bb9
Autor:
Arndt Borkhardt, Nan Qin, Stephen T Keir, Darell D Bigner, Allison Cole, Matthias Wölfl, Viktoria Marquardt, Johanna Theruvath, David Pauck, Daniel Picard, Lena Blümel, Mara Maue, Jasmin Bartl, Ulvi Ahmadov, Maike Langini, Frauke-Dorothee Meyer, Joselyn Cruz-Cruz, Claus M Graef, Till Milde, Olaf Witt, Anat Erdreich-Epstein, Gabriel Leprivier, Ulf Kahlert, Anja Stefanski, Kai Stühler, Julia Hauer, Thomas Beez, Christiane B Knobbe-Thomsen, Ute Fischer, Jörg Felsberg, Finn K Hansen, Rajeev Vibhakar, Sujatha Venkatraman, Samuel H Cheshier, Guido Reifenberger, Thomas Kurz, Marc Remke, Siddhartha Mitra
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 1 (2023)
Background While major advances have been made in improving the quality of life and survival of children with most forms of medulloblastoma (MB), those with MYC-driven tumors (Grp3-MB) still suffer significant morbidity and mortality. There is an urg
Externí odkaz:
https://doaj.org/article/bea518d410cc4fd58c33516272b055a1
Autor:
Jurij Rosen, Gabriele Stoffels, Philipp Lohmann, Elena K. Bauer, Jan-Michael Werner, Michael Wollring, Marion Rapp, Jörg Felsberg, Martin Kocher, Gereon R. Fink, Karl-Josef Langen, Norbert Galldiks
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract In glioma patients, complete resection of the contrast-enhancing portion is associated with improved survival, which, however, cannot be achieved in a considerable number of patients. Here, we evaluated the prognostic value of O-(2-[18F]-flu
Externí odkaz:
https://doaj.org/article/c8cc6dde129449dab0492e21c7be0bdb
Autor:
Yonghe Wu, Michael Fletcher, Zuguang Gu, Qi Wang, Barbara Costa, Anna Bertoni, Ka-Hou Man, Magdalena Schlotter, Jörg Felsberg, Jasmin Mangei, Martje Barbus, Ann-Christin Gaupel, Wei Wang, Tobias Weiss, Roland Eils, Michael Weller, Haikun Liu, Guido Reifenberger, Andrey Korshunov, Peter Angel, Peter Lichter, Carl Herrmann, Bernhard Radlwimmer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Glioblastoma is divided into four subtypes based on molecular profiling at the methylome and transcriptome level. Here the authors perform an integrative analysis of these subtypes resulting in the identification of SOX10 whose loss induces a mesench
Externí odkaz:
https://doaj.org/article/50c3ca33473a428aa36c9a52cf6638ef
Autor:
Christina Wilms, Klaudia Lepka, Felix Häberlein, Steven Edwards, Jörg Felsberg, Linda Pudelko, Tobias T. Lindenberg, Gereon Poschmann, Nan Qin, Katrin Volbracht, Tim Prozorovski, Sven G. Meuth, Ulf D. Kahlert, Marc Remke, Orhan Aktas, Guido Reifenberger, Lars Bräutigam, Benjamin Odermatt, Carsten Berndt
Publikováno v:
Redox Biology, Vol 49, Iss , Pp 102221- (2022)
Redox regulation of specific cysteines via oxidoreductases of the thioredoxin family is increasingly being recognized as an important signaling pathway. Here, we demonstrate that the cytosolic isoform of the vertebrate-specific oxidoreductase Glutare
Externí odkaz:
https://doaj.org/article/2e1d65566877484caf8912ee69a75699
Autor:
Dayana Herrera-Rios, Sadaf S. Mughal, Sarah Teuber-Hanselmann, Daniela Pierscianek, Antje Sucker, Philipp Jansen, Tobias Schimming, Joachim Klode, Julia Reifenberger, Jörg Felsberg, Kathy Keyvani, Benedikt Brors, Ulrich Sure, Guido Reifenberger, Dirk Schadendorf, Iris Helfrich
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The manifestation of brain metastases in patients with advanced melanoma is a common event that limits patient's survival and quality of life. The immunosuppressive properties of the brain parenchyma are very different compared to the rest of the bod
Externí odkaz:
https://doaj.org/article/d7ca3736e1934324947ac283f37f4b6b
Autor:
Renáta Váraljai, Susanne Horn, Antje Sucker, Daniela Piercianek, Verena Schmitt, Alexander Carpinteiro, Katrin Anne Becker, Julia Reifenberger, Alexander Roesch, Jörg Felsberg, Guido Reifenberger, Ulrich Sure, Dirk Schadendorf, Iris Helfrich
Publikováno v:
Cancers, Vol 13, Iss 4, p 731 (2021)
Background: Development of brain metastases in advanced melanoma patients is a frequent event that limits patients’ quality of life and survival. Despite recent insights into melanoma genetics, systematic analyses of genetic alterations in melanoma
Externí odkaz:
https://doaj.org/article/7147a95d0e8540bb9702c0d3427e7ec0
Autor:
Anna von dem Knesebeck, Jörg Felsberg, Anke Waha, Wolfgang Hartmann, Björn Scheffler, Martin Glas, Jennifer Hammes, Thomas Mikeska, Pearlly S. Yan, Elmar Endl, Matthias Simon, Guido Reifenberger, Torsten Pietsch, Andreas Waha
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 6, Pp 526-534 (2012)
Alterations of DNA methylation play an important role in gliomas. In a genome-wide screen, we identified a CpG-rich fragment within the 5′ region of the tumor necrosis factor receptor superfamily, member 11A gene (TNFRSF11A) that showed de novo met
Externí odkaz:
https://doaj.org/article/6bcdf744c4e347c18ce37bd01c340bfa
Autor:
Rebecca Schüle, Christine Dictus, Benito Campos, Feng Wan, Jörg Felsberg, Rezvan Ahmadi, Franz-Simon Centner, Niels Grabe, Guido Reifenberger, Justo L. Bermejo, Andreas Unterberg, Christel Herold-Mende
Publikováno v:
The Scientific World Journal, Vol 2012 (2012)
Aberrant wnt pathway activation through cytoplasmic stabilization of β-catenin is crucial for the development of various human malignancies. In gliomagenesis, the role of canonical (i.e., β-catenin-dependent) signalling is largely unknown. Here, we
Externí odkaz:
https://doaj.org/article/bb77107914894c30827efc84b56be322
Autor:
Sandra Pohl, Lora Dimitrova, Maja Grassow-Narlik, Korinna Jöhrens, Till Acker, Hildegard Dohmen, Jochen Herms, Mario Dorostkar, Christian Hartmann, Martin Hasselblatt, Manuela Neumann, Guido Reifenberger, Jörg Felsberg, Ulrich Schüller, Saida Zoubaa, Julia Lorenz, Tanja Rothhammer-Hampl, Katrin Mauch-Mücke, Markus J. Riemenschneider
Publikováno v:
Clinical Neuropathology. 42:112-121