A trafficome-wide RNAi screen reveals deployment of early and late secretory host proteins and the entire late endo-/lysosomal vesicle fusion machinery by intracellular Salmonella.

Autor: Alexander Kehl, Vera Göser, Tatjana Reuter, Viktoria Liss, Maximilian Franke, Christopher John, Christian P Richter, Jörg Deiwick, Michael Hensel

Publikováno v: PLoS Pathogens, Vol 16, Iss 7, p e1008220 (2020)

The intracellular lifestyle of Salmonella enterica is characterized by the formation of a replication-permissive membrane-bound niche, the Salmonella-containing vacuole (SCV). As a further consequence of the massive remodeling of the host cell endoso

Externí odkaz: https://doaj.org/article/2a294e5fd43b41388e1aa25151f18d3a

A trafficome-wide RNAi screen reveals deployment of early and late secretory host proteins and the entire late endo-/lysosomal vesicle fusion machinery by intracellular Salmonella

Autor: Michael Hensel, Christopher John, Tatjana Reuter, Vera Göser, Jörg Deiwick, Christian Richter, Viktoria Liss, Alexander Kehl, Maximilian Franke

Publikováno v: PLoS Pathogens, Vol 16, Iss 7, p e1008220 (2020)
PLoS Pathogens

The intracellular lifestyle of Salmonella enterica is characterized by the formation of a replication-permissive membrane-bound niche, the Salmonella-containing vacuole (SCV). As a further consequence of the massive remodeling of the host cell endoso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fabed12aaf9ddcee239f464f0e556d3f
https://doaj.org/article/2a294e5fd43b41388e1aa25151f18d3a

Structure-based functional analysis of effector protein SifA in living cells reveals motifs important for Salmonella intracellular proliferation

Autor: Mahsa Namakchian, Michael Hensel, Kristin Kassler, Jörg Deiwick, Heinrich Sticht

Publikováno v: International journal of medical microbiology : IJMM. 308(1)

The facultative intracellular pathogen Salmonella enterica survives and replicates inside the Salmonella-containing vacuole (SCV) of mammalian host cells. SifA is a key effector protein translocated by a type III secretion system and involved in form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6fca6414614fc6bc0ae4814377a41f
https://pubmed.ncbi.nlm.nih.gov/28939436

The Translocated Salmonella Effector Proteins SseF and SseG Interact and Are Required To Establish an Intracellular Replication Niche

Autor: Jean-Pierre Gorvel, Stéphane Méresse, Sarah M. Gilliland, Thomas Henry, David W. Holden, Emmanuel Boucrot, Jörg Deiwick, Scott R. Waterman, Nele Petermann, Suzana P. Salcedo

Publikováno v: Infection and Immunity
Infection and Immunity, American Society for Microbiology, 2006, 74 (12), pp.6965-72. ⟨10.1128/IAI.00648-06⟩
Infection and Immunity, 2006, 74 (12), pp.6965-72. ⟨10.1128/IAI.00648-06⟩

The facultative intracellular pathogen Salmonella enterica causes a variety of diseases, including gastroenteritis and typhoid fever. Inside epithelial cells, Salmonella replicates in vacuoles, which localize in the perinuclear area in close proximit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e17f6fb9ffcff30c0ee9667f0de41d58
https://doi.org/10.1128/iai.00648-06

Proteomes of Host Cell Membranes Modified by Intracellular Activities of Salmonella enterica*

Autor: Nicole Hansmeier, Jörg Deiwick, Michael Hensel, Viktoria Krieger, Stephanie Vorwerk

Intracellular pathogens need to establish a growth-stimulating host niche for survival and replication. A unique feature of the gastrointestinal pathogen Salmonella enterica serovar Typhimurium is the creation of extensive membrane networks within it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3236b020d14d819c3389bfc646a51fab
https://europepmc.org/articles/PMC4288265/