Osmotic pressure modulates single cell cycle dynamics inducing reversible growth arrest and reactivation of human metastatic cells

Autor: Hubert M. Taïeb, Daniela S. Garske, Jörg Contzen, Manfred Gossen, Luca Bertinetti, Tom Robinson, Amaia Cipitria

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Biophysical cues such as osmotic pressure modulate proliferation and growth arrest of bacteria, yeast cells and seeds. In tissues, osmotic regulation takes place through blood and lymphatic capillaries and, at a single cell level, water and

Externí odkaz: https://doaj.org/article/1514b2a9b79e4d038cb3e1de5d69c3ac

Quiescence-inducing 3D-engineered matrix uncovers mechanosensitive and drug protective FHL2-p21 signaling axis

Autor: Sadra Bakhshandeh, Hubert M. Taïeb, Adithi R. Varadarajan, Susanna M. Lissek, Sarah M. Hücker, Xin Lu, Daniela S. Garske, Sarah A. E. Young, Jörg Contzen, Manfred Gossen, Stefan Kirsch, Jens Warfsmann, Kamran Honarnejad, Christoph A. Klein, Amaia Cipitria

Resected tumors frequently relapse with distant metastasis, despite systemic treatment. Cellular quiescence has been identified as an important mechanism underlying such drug resistance enabling late relapse. Nonetheless, hurdles associated with dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82a24605666b1a7b87c30e6988c35238
https://doi.org/10.1101/2023.01.25.525382

Osmotic pressure modulates single cell cycle dynamics inducing reversible growth arrest and reactivation of human metastatic cells

Autor: Tom Robinson, Manfred Gossen, Hubert M. Taïeb, Luca Bertinetti, Daniela S. Garske, Amaia Cipitria, Jörg Contzen

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Taieb, H.; Garske, D.; Contzen, J.; Gossen, M.; Bertinetti, L.; Robinson, T.; Cipitria, A.: Osmotic pressure modulates single cell cycle dynamics inducing reversible growth arrest and reactivation of human metastatic cells. In: Scientific Reports. Vol. 111 (2021) 1, 13455. (DOI: /10.1038/s41598-021-92054-w)

Biophysical cues such as osmotic pressure modulate proliferation and growth arrest of bacteria, yeast cells and seeds. In tissues, osmotic regulation takes place through blood and lymphatic capillaries and, at a single cell level, water and osmoregul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f1bb373055ed09fafd43dd8e01e873
https://doi.org/10.1038/s41598-021-92054-w

Selective cell targeting and lineage tracing of human induced pluripotent stem cells using recombinant avian retroviruses

Autor: Andreas Kurtz, Laura de Campos Hildebrand, Petra Seemann, Jörg Contzen, Harald Stachelscheid, Jochen Hecht, Manfred Gossen

Publikováno v: Cellular and molecular life sciences : CMLS. 72(23)

Human induced pluripotent stem cells (hiPSC) differentiate into multiple cell types. Selective cell targeting is often needed for analyzing gene function by overexpressing proteins in a distinct population of hiPSC-derived cell types and for monitori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6667bf6f289bf11d5ba987ad013894ee
https://pubmed.ncbi.nlm.nih.gov/26109426

Multi-frequency EPR and Mössbauer spectroscopic studies on freeze-quenched reaction intermediates of nitric oxide synthase

Autor: Christiane Jung, Volker Schünemann, Friedhelm Lendzian, Marcus Galander, Jörg Contzen, Alfred X. Trautwein, Lars H. Böttger, Anne-Laure Barra, D. K. Ghosh, M. Richter

Publikováno v: Magnetic Resonance in Chemistry. 43:S84-S95

It is believed by analogy to chloroperoxidase (CPO) from Caldariomyces fumago that the electronic structure of the intermediate iron-oxo species in the catalytic cycle of nitric oxide synthase (NOS) corresponds to an iron(IV) porphyrin-π -cation rad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75f52f654a724c72eab511b494feaa1
https://doi.org/10.1002/mrc.1694