Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Jörg Breitkreutz"'
Publikováno v:
International Journal of Pharmaceutics: X, Vol 7, Iss , Pp 100243- (2024)
In recent years, the application of fixed dose combinations of antiretroviral drugs in HIV therapy has been established. Despite numerous therapeutic benefits, this approach poses several challenges for the formulation development especially when poo
Externí odkaz:
https://doaj.org/article/f2c5c13701a946a6acaf16b1364a3906
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100082- (2021)
Desmopressin acetate (DDAVP) is an oligopeptide indicated for the treatment of primary nocturnal enuresis, for example. The poor oral bioavailability of DDAVP accelerated a shift to alternative routes of administration like nasal and oromucosal, wher
Externí odkaz:
https://doaj.org/article/d751fa37743549e3826bbfe6587b5fcf
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2411 (2022)
Fused deposition modeling (FDM) 3D printing was used to produce 3D printed tablets with the thermo-sensitive model peptidomimetic drug enalapril maleate (EM). Two different formulations were prepared to investigate the degradation of enalapril maleat
Externí odkaz:
https://doaj.org/article/ad61fbad97564100843b3fc5ecc21391
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2091 (2022)
The aim of this research was the production of extrudates for the treatment of hypertension and heart failure and the investigation of the degradation of the peptidomimetic drug enalapril maleate (EM) during hot-melt extrusion (HME). A fast HPLC meth
Externí odkaz:
https://doaj.org/article/5ecb29a5f1b345a3ad0e678eb64c6491
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1580 (2022)
An automated compounding device can be a useful tool for the rapid and accurate production of small batches for personalized medicine as well as for clinical batches. A novel electronic liquid dispensing system (ELDS) was investigated to produce hard
Externí odkaz:
https://doaj.org/article/0829ef45deaf48bf84a7436fb7914678
Autor:
Stephanie Laeer, Willi Cawello, Bjoern B. Burckhardt, László Ablonczy, Milica Bajcetic, Johannes M. P. J. Breur, Michiel Dalinghaus, Christoph Male, Saskia N. de Wildt, Jörg Breitkreutz, Muhammed Faisal, Anne Keatley-Clarke, Ingrid Klingmann, Florian B. Lagler
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1163 (2022)
Angiotensin-converting enzyme inhibitors (ACEI), such as enalapril, are a cornerstone of treatment for pediatric heart failure which is still used off-label. Using a novel age-appropriate formulation of enalapril orodispersible minitablets (ODMTs), p
Externí odkaz:
https://doaj.org/article/b89dc3f16c3f4e7d9e7d6a9dfa33561e
Publikováno v:
International Journal of Pharmaceutics: X, Vol 2, Iss , Pp 100061- (2020)
Mini-tablets are solid dosage forms with increasing interest for pharmaceutical industry due to clinical and biopharmaceutical benefits. But technological aspects on mini-tableting are not fully investigated. Therefore, the impact of punch size and t
Externí odkaz:
https://doaj.org/article/624529f61c544dcb9be5ff2c5aa5cd09
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 931 (2022)
Therapy for Parkinson’s disease is quite challenging. Numerous drugs are available for symptomatic treatment, and levodopa (LD), in combination with a dopa decarboxylase inhibitor (e.g., benserazide (BZ)), has been the drug of choice for years. As
Externí odkaz:
https://doaj.org/article/a743e5e4d30b4945ac65bb74f3fb2a07
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 570 (2022)
Epidermolysis bullosa is a genetically heterogenous skin fragility disorder with multiorgan involvement appearing already in newborn children. Severe progressive fibrosis follows skin blistering, mucosa lesions, and wound healing, favouring developme
Externí odkaz:
https://doaj.org/article/3213f6bc4dc048ac8e7d8ed3332e1415
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 639 (2022)
Individual dosing of pharmaceutics and personalized medicine have become important with regard to therapeutic safety. Dose adjustments, biorelevant drug release and combination of multiple active substances in one dosage form for the reduction in pol
Externí odkaz:
https://doaj.org/article/d85f0fd7ef65454faddb5da9649e0025