Zobrazeno 1 - 10
of 289
pro vyhledávání: '"Jörg, Tost"'
Autor:
Thomas Fleischer, Mads Haugland Haugen, Jørgen Ankill, Laxmi Silwal‐Pandit, Anne‐Lise Børresen‐Dale, Ingrid Hedenfalk, Thomas Hatschek, Jörg Tost, Olav Engebraaten, Vessela N. Kristensen
Publikováno v:
Molecular Oncology, Vol 18, Iss 8, Pp 2042-2059 (2024)
Treatment with the anti‐angiogenic drug bevacizumab in addition to chemotherapy has shown efficacy for breast cancer in some clinical trials, but better biomarkers are needed to optimally select patients for treatment. Here, we present an omics app
Externí odkaz:
https://doaj.org/article/943a77752b1e4da48443c28cd3393e9f
Autor:
Paulina Jedynak, Valérie Siroux, Lucile Broséus, Jörg Tost, Florence Busato, Stephan Gabet, Cathrine Thomsen, Amrit K. Sakhi, Azemira Sabaredzovic, Sarah Lyon-Caen, Sam Bayat, Rémy Slama, Claire Philippat, Johanna Lepeule
Publikováno v:
Environment International, Vol 189, Iss , Pp 108763- (2024)
Background: Endocrine disrupting compounds (EDCs) such as phthalates and phenols can affect placental functioning and fetal health, potentially via epigenetic modifications. We investigated the associations between pregnancy exposure to synthetic phe
Externí odkaz:
https://doaj.org/article/08ce7faceb744fbe97e0d4ac462516e5
Autor:
Lucile Broséus, Daniel Vaiman, Jörg Tost, Camino Ruano San Martin, Milan Jacobi, Joel D. Schwartz, Rémi Béranger, Rémy Slama, Barbara Heude, Johanna Lepeule
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-15 (2022)
Abstract Background Maternal blood pressure levels reflect cardiovascular adaptation to pregnancy and proper maternal-fetal exchanges through the placenta and are very sensitive to numerous environmental stressors. Maternal hypertension during pregna
Externí odkaz:
https://doaj.org/article/13a3a51580db4d4792fadb0ba7b57d25
Autor:
Sunniva Stordal Bjørklund, Miriam Ragle Aure, Jari Häkkinen, Johan Vallon-Christersson, Surendra Kumar, Katrine Bull Evensen, Thomas Fleischer, Jörg Tost, OSBREAC, Kristine K. Sahlberg, Anthony Mathelier, Gyan Bhanot, Shridar Ganesan, Xavier Tekpli, Vessela N. Kristensen
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Long non-coding RNAs (lncRNAs) have been shown to be involved in breast cancer pathogenesis through regulation of multiple steps of gene expression. lncRNA expression patterns are also associated with breast cancer clinicopathological features in lar
Externí odkaz:
https://doaj.org/article/d578e026b6684471a4b2a49871d7ef32
Autor:
Marion Lecorguillé, Marie-Aline Charles, Johanna Lepeule, Sandrine Lioret, Blandine de Lauzon-Guillain, Anne Forhan, Jörg Tost, Matthew Suderman, Barbara Heude
Publikováno v:
Epigenetics, Vol 17, Iss 7, Pp 715-730 (2022)
The preconception period represents an important window for foetal and epigenetic programming. Some micronutrients (B vitamins, choline, betaine, methionine) implicated in one-carbon metabolism (OCM) are essential for major epigenetic processes that
Externí odkaz:
https://doaj.org/article/ba4115259c6944dba63e9602d5a93642
Autor:
Christine Aaserød Pedersen, Maria Dung Cao, Thomas Fleischer, Morten B. Rye, Stian Knappskog, Hans Petter Eikesdal, Per Eystein Lønning, Jörg Tost, Vessela N. Kristensen, May-Britt Tessem, Guro F. Giskeødegård, Tone F. Bathen
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-14 (2022)
Abstract Background Locally advanced breast cancer is a heterogeneous disease with respect to response to neoadjuvant chemotherapy (NACT) and survival. It is currently not possible to accurately predict who will benefit from the specific types of NAC
Externí odkaz:
https://doaj.org/article/1e0f5801a9e14e8d979b6ce43580972f
Autor:
Aurélie Nakamura, Lucile Broséus, Jörg Tost, Daniel Vaiman, Silvia Martins, Katherine Keyes, Kim Bonello, Mathilde Fekom, Katrine Strandberg-Larsen, Anne-Laure Sutter-Dallay, Barbara Heude, Maria Melchior, Johanna Lepeule
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11772 (2023)
The placenta is a key organ for fetal and brain development. Its epigenome can be regarded as a biochemical record of the prenatal environment and a potential mechanism of its association with the future health of the fetus. We investigated associati
Externí odkaz:
https://doaj.org/article/11bca35aeac64731bab870abe8c5a9aa
Autor:
Miriam Ragle Aure, Thomas Fleischer, Sunniva Bjørklund, Jørgen Ankill, Jaime A. Castro-Mondragon, OSBREAC, Anne-Lise Børresen-Dale, Jörg Tost, Kristine K. Sahlberg, Anthony Mathelier, Xavier Tekpli, Vessela N. Kristensen
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-21 (2021)
Abstract Background Abnormal DNA methylation is observed as an early event in breast carcinogenesis. However, how such alterations arise is still poorly understood. microRNAs (miRNAs) regulate gene expression at the post-transcriptional level and pla
Externí odkaz:
https://doaj.org/article/827ee91e402744f898c0fde2f0fcf10a
Autor:
Paulina Jedynak, Jörg Tost, Antonia M. Calafat, Ekaterina Bourova-Flin, Lucile Broséus, Florence Busato, Anne Forhan, Barbara Heude, Milan Jakobi, Joel Schwartz, Rémy Slama, Daniel Vaiman, Johanna Lepeule, Claire Philippat
Publikováno v:
Environment International, Vol 160, Iss , Pp 107054- (2022)
Background: Exposure to phthalates during pregnancy may alter DNA methylation in the placenta, a crucial organ for the growth and development of the fetus. Objectives: We studied associations between urinary concentrations of phthalate biomarkers dur
Externí odkaz:
https://doaj.org/article/3ecd5e4a72014de1b5d9741376231732
Autor:
Olivier Fogel, Andreas Bugge Tinggaard, Maud Fagny, Nelly Sigrist, Elodie Roche, Laurence Leclere, Jean-François Deleuze, Frederic Batteux, Maxime Dougados, Corinne Miceli-Richard, Jörg Tost
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-14 (2019)
Abstract Background MicroRNAs (MiRs) play an important role in the pathogenesis of chronic inflammatory diseases. This study is the first to investigate miR expression profiles in purified CD4+ T lymphocytes and CD14+ monocytes from patients with axi
Externí odkaz:
https://doaj.org/article/860661af406d4e95a9f147d312eb70a3