Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Jörg, Hüser"'
Autor:
Eva M. Becker-Pelster, Michael G. Hahn, Martina Delbeck, Lisa Dietz, Jörg Hüser, Johannes Kopf, Thomas Kraemer, Tobias Marquardt, Thomas Mondritzki, Johannes Nagelschmitz, Sylvia M. Nikkho, Philippe V. Pires, Hanna Tinel, Gerrit Weimann, Frank Wunder, Peter Sandner, Joachim Schuhmacher, Johannes-Peter Stasch, Hubert K. F. Truebel
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Background Oxidative stress associated with severe cardiopulmonary diseases leads to impairment in the nitric oxide/soluble guanylate cyclase signaling pathway, shifting native soluble guanylate cyclase toward heme-free apo-soluble guanylate
Externí odkaz:
https://doaj.org/article/a7434a456b0646fda04bc3440b78080a
Autor:
Ellis Nelissen, Nina Possemis, Nick P. Van Goethem, Melissa Schepers, Danielle A. J. Mulder-Jongen, Lisa Dietz, Wiebke Janssen, Michael Gerisch, Jörg Hüser, Peter Sandner, Tim Vanmierlo, Jos Prickaerts
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Soluble guanylate cyclase (sGC) requires a heme-group bound in order to produce cGMP, a second messenger involved in memory formation, while heme-free sGC is inactive. Two compound classes can increase sGC activity: sGC stimulators acting on
Externí odkaz:
https://doaj.org/article/d63fa56a4c67428fba25c3c4f7e5efab
Autor:
Daniel Meibom, Jutta Meyer, Clemens-Jeremias von Buehler, Karl D. Collins, Stefanie Maassen, Kersten Matthias Gericke, Jörg Hüser, Joachim Mittendorf, Nuria Ortega Hernandez, Jens Schamberger, Jan Stampfuss, Alexander Straub, Afra Torge, Norbert Witowski, Frank Wunder
Publikováno v:
Journal of Medicinal Chemistry. 66:4659-4670
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::237ca05b85c7ada3d8c368e6049cfd97
https://doi.org/10.1021/acs.jmedchem.2c01690
https://doi.org/10.1021/acs.jmedchem.2c01690
Publikováno v:
Drug Discovery Today. 27:1326-1331
Although 'unmet medical need' (UMN) is an increasingly used term in the healthcare sector instrumental to the approximate value of drug discovery projects relevant to portfolio management, no standardized approach exists for its quantification. Espec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df604633f340bec92eba1ec73ce36fca
https://doi.org/10.1016/j.drudis.2021.12.019
https://doi.org/10.1016/j.drudis.2021.12.019
Autor:
Alexander Schmidt, Jakob Balitzki, Ljubica Grmaca, Julia Vogel, Philip Boehme, Katharina Boden, Jörg Hüser, Hubert Truebel, Thomas Mondritzki
Publikováno v:
Heart failure reviews.
Innovations in the development of novel heart failure therapies are essential to further increase the predictive value of early research findings. Animal models are still playing a pivotal role in ‘translational research’. In recent years, the tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34e130583f707a8f62a46dca9fe74f2
https://pubmed.ncbi.nlm.nih.gov/36001250
https://pubmed.ncbi.nlm.nih.gov/36001250
Publikováno v:
Cardiovascular Research
Cardiovasc Res
Cardiovasc Res
Atrial fibrillation (AF) is the most common sustained clinical arrhythmia, with a lifetime incidence of up to 37%, and is a major contributor to population morbidity and mortality. Important components of AF management include control of cardiac rhyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cd26c1bd6610f5073d0ec663f25f66
https://doi.org/10.1093/cvr/cvab093
https://doi.org/10.1093/cvr/cvab093
Autor:
Karoline Droebner, Peter Kolkhof, Elke Hartmann, Peter Sandner, Frank Eitner, Mira Pavkovic, Amer Joseph, Jörg Hüser, Ilka Mathar, Alexius Freyberger
Publikováno v:
Am J Nephrol
Introduction: The nonsteroidal mineralocorticoid receptor (MR) antagonist finerenone and sodium-glucose cotransporter-2 (SGLT2) inhibitors have demonstrated clinical benefits in CKD patients with type 2 diabetes. Clinical data analyzing the potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45906e26f44f067c747651dfdea2bc0e
https://doi.org/10.1159/000516213
https://doi.org/10.1159/000516213
Autor:
Jörg Hüser, Lisa Dietz, Alexandros Vakalopoulos, Roland Seifert, Ilka Mathar, Peter Sandner, Shalini M Krishnan, Petra Haning, Elke Hartmann, Johannes Nordlohne
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 15
International Journal of Molecular Sciences, Vol 22, Iss 8016, p 8016 (2021)
Volume 22
Issue 15
International Journal of Molecular Sciences, Vol 22, Iss 8016, p 8016 (2021)
Duchenne muscular dystrophy (DMD) is a severe and progressive muscle wasting disorder, affecting one in 3500 to 5000 boys worldwide. The NO-sGC-cGMP pathway plays an important role in skeletal muscle function, primarily by improving blood flow and ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9b54df1cc326e6680b6112552affdd
Autor:
Mira Pavkovic, Jörg Hüser, Martina Delbeck, Pierre Wasnaire, Anja Buchmüller, Wilfried Dinh, Thomas Mondritzki, Elisabeth Pook, Hanna Tinel, Axel Kretschmer, Carsten Schmeck, Hubert Truebel, Peter Kolkhof
Publikováno v:
Journal of Cardiovascular Pharmacology. 74:44-52
Increased plasma vasopressin levels have been shown to be associated with the progression of congestive heart failure. Vasopressin mediates water retention by renal tubular V2 receptor activation as well as vasoconstriction, cardiac hypertrophy, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ba46fb465addea10690793d97c93fe
https://doi.org/10.1097/fjc.0000000000000677
https://doi.org/10.1097/fjc.0000000000000677
Autor:
Julia Vogel, Thomas Reimer, Jörg Hüser, Katharina Boden, Peter Sandner, Thomas Mondritzki, Wilfried Dinh, Hubert Truebel, Philip Boehme, Reza Wakili
Publikováno v:
Journal of Translational Science. 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f59d2500bdda8aa8b8b5d30056689122
https://doi.org/10.15761/jts.1000408
https://doi.org/10.15761/jts.1000408