Phosphatidylserine exposure is required for ADAM17 sheddase function

Autor: Anselm Sommer, Felix Kordowski, Joscha Büch, Thorsten Maretzky, Astrid Evers, Jörg Andrä, Stefan Düsterhöft, Matthias Michalek, Inken Lorenzen, Prasath Somasundaram, Andreas Tholey, Frank D. Sönnichsen, Karl Kunzelmann, Lena Heinbockel, Christian Nehls, Thomas Gutsmann, Joachim Grötzinger, Sucharit Bhakdi, Karina Reiss

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

ADAM17 is a member of the ‘Disintegrin and Metalloproteinase’ family of proteases, that cleaves transmembrane substrates from the surfaces of cells. Here the authors show that surface exposure of phosphatidylserine is required for ADAM17 sheddase

Externí odkaz: https://doaj.org/article/7d870aa38fd548259ffdc80c22adca2f

ADAM10 sheddase activation is controlled by cell membrane asymmetry

Autor: Jörg Andrä, Björn Rabe, Karl Kunzelmann, Anselm Sommer, Florian Bleibaum, Karina Reiss, Martin Veit, Christian Nehls, Sucharit Bhakdi, Wilmar Correa, Joachim Grötzinger, Thomas Gutsmann

Publikováno v: Journal of Molecular Cell Biology

Dysregulation of the disintegrin-metalloproteinase ADAM10 may contribute to the development of diseases including tumorigenesis and Alzheimer’s disease. The mechanisms underlying ADAM10 sheddase activation are incompletely understood. Here, we show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7168d4e94cf8eed54a147c83c42b4a22
http://europepmc.org/articles/PMC6927242

Comparison of patient-derived high and low phosphatidylserine-exposing colorectal carcinoma cells in their interaction with anti-cancer peptides

Autor: Jörg Andrä, Dominik Wilms

Publikováno v: Journal of Peptide Science. 23:56-67

Current cancer treatment is frequently compromised by severe adverse effects on healthy cells and tissues as well as by the increasing burden of (multi-)drug resistances. Some representatives of small, amphipathic peptides known as host defense pepti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::090556afa93a6b18958263424b3bd8df
https://doi.org/10.1002/psc.2963

PharmCycle:a holistic approach to reduce the contamination of the aquatic environment with antibiotics by developing sustainable antibiotics, improving the environmental risk assessment of antibiotics, and reducing the discharges of antibiotics in the wastewater outlet

Autor: Klaus Kümmerer, Gesine Cornelissen, Kim Oelkers, Falk Beyer, Jörg Andrä, Carolin Floeter, Jens Heseding, Jörn Einfeldt

Publikováno v: Andrae, J, Beyer, F, Cornelissen, G, Einfeldt, J, Heseding, J, Kuemmerer, K, Oelkers, K & Floeter, C 2018, ' PharmCycle : a holistic approach to reduce the contamination of the aquatic environment with antibiotics by developing sustainable antibiotics, improving the environmental risk assessment of antibiotics, and reducing the discharges of antibiotics in the wastewater outlet ', Environmental Sciences Europe, vol. 30, no. 1, 24 . https://doi.org/10.1186/s12302-018-0156-y
Andrae, J, Beyer, F, Cornelissen, G, Einfeldt, J, Heseding, J, Kuemmerer, K, Oelkers, K & Floeter, C 2018, ' PharmCycle : a holistic approach to reduce the contamination of the aquatic environment with antibiotics by developing sustainable antibiotics, improving the environmental risk assessment of antibiotics, and reducing the discharges of antibiotics in the wastewater outlet ' Environmental Sciences Europe, vol 30, 24 . DOI: 10.1186/s12302-018-0156-y
Environmental Sciences Europe, Vol 30, Iss 1, Pp 1-7 (2018)

Background The overall aim of the interdisciplinary research project “PharmCycle” is to reduce the contamination of the aquatic environment with antibiotics by developing sustainable antibiotics, improving the environmental risk assessment of ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d42d898be4a74090162cfc00e4edeb3
https://pure.leuphana.de/ws/files/11027436/Andr_2018_Article_PharmCycleAHolisticApproachToR.pdf

Host defense peptides for treatment of colorectal carcinoma - a comparative in vitro and in vivo analysis

Autor: Claudia Maletzki, Michael Linnebacher, Ulrike Klier, Jörg Andrä, Ernst Klar, Samuel Marinkovic

Publikováno v: Oncotarget

Host defense peptides (HDP) constitute effector molecules of the innate immune system. Besides acting against microbia and fungi, they exhibit broad and selective oncolytic activity. The underlying mechanism is at least partially attributable to elev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ad4eee04f79905d509f4884f33dfc1
https://doi.org/10.18632/oncotarget.2039