Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Józef, Dulak"'
Autor:
Jan Wolnik, Patrycja Adamska, Aleksandra Oleksy, Anna Magdalena Sanetra, Katarzyna Palus-Chramiec, Marian Henryk Lewandowski, Józef Dulak, Monika Biniecka
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects not only the joints but also has significant cardiovascular (CV) manifestations. The mechanistic interplay between RA and cardiovascular complications is not
Externí odkaz:
https://doaj.org/article/2db2a3a2e82c42369e3e8dc261d17dd5
Autor:
Urszula Florczyk-Soluch, Katarzyna Polak, Sarka Jelinkova, Iwona Bronisz-Budzyńska, Reece Sabo, Subhashini Bolisetty, Anupam Agarwal, Ewa Werner, Alicja Józkowicz, Jacek Stępniewski, Krzysztof Szade, Józef Dulak
Publikováno v:
Skeletal Muscle, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Background Adult muscle-resident myogenic stem cells, satellite cells (SCs), that play non-redundant role in muscle regeneration, are intrinsically impaired in Duchenne muscular dystrophy (DMD). Previously we revealed that dystrophic SCs exp
Externí odkaz:
https://doaj.org/article/726a69ef7b32411b9f36f14dae252c48
Autor:
Marta Przymuszała, Alicja Martyniak, Joanna Kwiatkowska, Jarosław Meyer-Szary, Karolina Śledzińska, Jolanta Wierzba, Józef Dulak, Urszula Florczyk-Soluch, Jacek Stępniewski
Publikováno v:
Stem Cell Research, Vol 76, Iss , Pp 103327- (2024)
Becker muscular dystrophy (BMD) is an X-linked recessive disorder caused by in-frame deletions in the dystrophin gene (DMD), leading to progressive muscle degeneration and weakness. We generated a human induced pluripotent stem cell (hiPSC) line from
Externí odkaz:
https://doaj.org/article/5986f4f03cf44232b9a3e192e86d605e
Autor:
Olga Mucha, Paulina Podkalicka, Monika Żukowska, Ewelina Pośpiech, Józef Dulak, Agnieszka Łoboda
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Skeletal muscle regeneration relies on the reciprocal interaction between many types of cells. Regenerative capacity may be altered in different disorders. In our study, we investigated whether the deletion of miR-378a (miR-378) affects musc
Externí odkaz:
https://doaj.org/article/bb84564b4ad84804a5000fbf158dda0d
Autor:
Eda Dev, Patrycja Adamska, Jan Wolnik, Aleksandra Oleksy, Zuzanna Piętowska, Adam Zalewski, Joanna Maj, Józef Dulak, Monika Biniecka
Publikováno v:
Stem Cell Research, Vol 73, Iss , Pp 103251- (2023)
Psoriasis (Ps) is a chronic, inflammatory skin disease characterized by thickened, red and scaly plaques. Systemic inflammation associated with psoriasis results in an increased risk of death due to the development of psoriasis-associated comorbiditi
Externí odkaz:
https://doaj.org/article/80f12b17ddf54ab3b4bbc738cc26b511
Autor:
Katarzyna Sarad, Monika Stefańska, Izabela Kraszewska, Krzysztof Szade, Judith C. Sluimer, Przemysław Błyszczuk, Józef Dulak, Agnieszka Jaźwa-Kusior
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcriptional regulator of antioxidant and anti-inflammatory response in all cell types. It also activates the transcription of genes important for macrophage function. Nrf2 activity declines
Externí odkaz:
https://doaj.org/article/16864a7f1bc8417393a7b1c3d0045d44
Autor:
Agnieszka Łoboda, Józef Dulak
Publikováno v:
Cells, Vol 13, Iss 2, p 158 (2024)
Hydrogen sulfide (H2S) belongs to the family of gasotransmitters and can modulate a myriad of biological signaling pathways. Among others, its cardioprotective effects, through antioxidant, anti-inflammatory, anti-fibrotic, and proangiogenic activiti
Externí odkaz:
https://doaj.org/article/785f69969ced42ea97dc25f43a6ddab0
Publikováno v:
Stem Cell Research, Vol 68, Iss , Pp 103046- (2023)
miR-15a/16-1 cluster, composed of MIR15A and MIR16-1 genes located in close proximity on chromosome 13 was described to regulate post-natal cell cycle withdrawal of cardiomyocytes in mice. In humans, on the other hand, the level of miR-15a-5p and miR
Externí odkaz:
https://doaj.org/article/b0ec8889b4194714b81ed9bc3c17ec32
Autor:
Olga Mucha, Małgorzata Myszka, Paulina Podkalicka, Bianka Świderska, Agata Malinowska, Józef Dulak, Agnieszka Łoboda
Publikováno v:
Biomolecules, Vol 13, Iss 11, p 1648 (2023)
Mdx mice with a spontaneous mutation in exon 23 of the Dmd gene represent the most common model to investigate the pathophysiology of Duchenne muscular dystrophy (DMD). The disease, caused by the lack of functional dystrophin, is characterized by irr
Externí odkaz:
https://doaj.org/article/b5a527238d524efe87466f14c2ea7a38
Autor:
Paulina Podkalicka, Olga Mucha, Katarzyna Kaziród, Krzysztof Szade, Jacek Stępniewski, Liudmyla Ivanishchuk, Hirofumi Hirao, Ewelina Pośpiech, Alicja Józkowicz, Jerzy W. Kupiec-Weglinski, Józef Dulak, Agnieszka Łoboda
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Although Duchenne muscular dystrophy (DMD) primarily affects muscle tissues, the alterations to systemic metabolism manifested in DMD patients contribute to the severe phenotype of this fatal disorder. We propose that microRNA-378a (miR-378)
Externí odkaz:
https://doaj.org/article/31f8767de0804f9ea3cdfb34755154d9