Výsledky vyhledávání - "Jéssica Mendes Bonato"

Blood-Brain Barrier Rescue by Roflumilast After Transient Global Cerebral Ischemia in Rats

Autor: Jéssica Mendes Bonato, Bianca Andretto de Mattos, Daniela Velasquez Oliveira, Humberto Milani, Jos Prickaerts, Rúbia Maria Weffort de Oliveira

Publikováno v: Neurotoxicity Research. Springer

Phosphodiesterase 4 inhibitors (PDE4-I), which selectively increase cyclic adenosine monophosphate (cAMP) levels, have shown neuroprotective effects after several neurological injuries inducing blood-brain barrier (BBB) damage including local/focal c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0a341d1764593c101eae23d59e7885
https://cris.maastrichtuniversity.nl/en/publications/e76d23d6-48b4-4dc3-bf97-188c2b63c57f

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Exploring cognitive and affective outcomes following bilateral 6-hydroxydopamine lesions of the substance nigra or striatum in rats

Autor: Bianca Andretto Mattos, Jéssica Mendes Bonato, Elaine Del Bel Guimarães, Humberto Milani, Rúbia Maria Weffort Oliveira

Purpose: The majority of animal models of Parkinson’s disease (PD) focus on motor symptoms that are induced by unilateral injections of such neurotoxins as 6-hydroxydopamine (6-OHDA) in nigrostriatal dopaminergic pathways. However, motor changes th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10ec8c3261dc1fd615dd955e8b2e4571
https://doi.org/10.21203/rs.3.rs-2289492/v1

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Cannabidiol Confers Neuroprotection in Rats in a Model of Transient Global Cerebral Ischemia: Impact of Hippocampal Synaptic Neuroplasticity

Autor: Jéssica Mendes Bonato, Erika Meyer, Francisco Silveira Guimarães, Marco Aurélio Mori, Bianca Andretto de Mattos, Humberto Milani, Alline C. Campos, Rúbia Maria Weffort de Oliveira

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Evidence for the clinical use of neuroprotective drugs for the treatment of cerebral ischemia (CI) is still greatly limited. Spatial/temporal disorientation and cognitive dysfunction are among the most prominent long-term sequelae of CI. Cannabidiol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1d8861957823c2fac433ffd1042d05
https://doi.org/10.1007/s12035-021-02479-7

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Roflumilast protects against spatial memory impairments and exerts anti‐inflammatory effects after transient global cerebral ischemia

Autor: Jos Prickaerts, Humberto Milani, Rúbia Maria Weffort de Oliveira, Patrícia Souza Bonfim de Mendonça, Jéssica Mendes Bonato, Erika Meyer

Publikováno v: European Journal of Neuroscience, 53(4), 1171-1188. Wiley

Phosphodiesterase 4 (PDE4) inhibitors have been shown to present beneficial effects in cerebral ischemic injury because of their ability to improve cognition and target different phases and mechanisms of cerebral ischemia, including apoptosis, neurog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca259e1887e91c59d2942687791fec9e
https://doi.org/10.1111/ejn.15089

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Further exploring cognitive and affective outcomes following bilateral 6- hydroxidopamine infusion into the substance nigra or striatum of rats

Autor: Bianca Andretto Mattos, Jéssica Mendes Bonato, Humberto Milani, Elaine Del Bel, Rubia Maria Weffort Oliveira

The majority of animal models of PD focus on the motor symptoms induced by unilateral injections of neurotoxins such as 6-hydroxidopamine (6-OHDA) in the nigrostriatal dopaminergic pathways. However, motor changes induced by unilateral 6-OHDA injecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0eeda55bf2691dad6f4b213f3e542e22
https://doi.org/10.21203/rs.3.rs-1731679/v1

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Positive effects of roflumilast on behavior, neuroinflammation, and white matter injury in mice with global cerebral ischemia

Autor: Tim Vanmierlo, Melissa Schepers, Jos Prickaerts, Emanuella R Vilhena, Humberto Milani, Rúbia Maria Weffort de Oliveira, Juliana K C Kunieda, Jéssica Mendes Bonato

Publikováno v: Behavioural Pharmacology, 32(6), 459-471. LIPPINCOTT WILLIAMS & WILKINS

Inhibition of phosphodiesterase 4 (PDE4) is a promising pharmacological strategy for the treatment of cerebral ischemic conditions. To increase the relevance and increase the translational value of preclinical studies, it is important to conduct expe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eba133a46b7560d81cc67a32c08c495
https://pubmed.ncbi.nlm.nih.gov/34320520

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Persistence of the extinction of fear memory requires late-phase cAMP/PKA signaling in the infralimbic cortex

Autor: Jéssica Mendes Bonato, Jos Prickaerts, Ana Maria Raymundi, Jeferson Machado Batista Sohn, Suzen Tortato Furtado de Souza, Rúbia Maria Weffort de Oliveira, Cristina A.J. Stern

Publikováno v: Neurobiology of Learning and Memory, 172:107244. Elsevier Science

Fear extinction is a form of new learning that inhibits expression of the original fear memory without erasing the conditioned stimulus-unconditioned stimulus association. Much is known about the mechanisms that underlie the acquisition of extinction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3262d97ff8a8e198aae81db7cc0071
https://doi.org/10.1016/j.nlm.2020.107244

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Pioglitazone reduces mortality, prevents depressive-like behavior, and impacts hippocampal neurogenesis in the 6-OHDA model of Parkinson's disease in rats

Autor: Maria A.B.F. Vital, Humberto Milani, Taysa Bervian Bassani, Rúbia Maria Weffort de Oliveira, Jéssica Mendes Bonato

Publikováno v: Experimental Neurology. 300:188-200

Deficiencies in adult hippocampal neurogenesis have been suggested to be a possible pathophysiological mechanism that underlies depressive symptoms that are often observed in patients with Parkinson's disease (PD). Pioglitazone, a selective peroxisom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf1bd9c13683d04d0d6709fdbd75a7c
https://doi.org/10.1016/j.expneurol.2017.11.009

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Effects of curcumin on short-term spatial and recognition memory, adult neurogenesis and neuroinflammation in a streptozotocin-induced rat model of dementia of Alzheimer's type

Autor: Rúbia M. M. W. Oliveira, Jéssica Mendes Bonato, Maria A.B.F. Vital, Valentín Coppola-Segovia, Joelle de Melo Turnes, Taysa Bervian Bassani, Eric L. R. Moura, Silvio M. Zanata

Publikováno v: Behavioural brain research. 335

Curcumin is a natural polyphenol with evidence of antioxidant, anti-inflammatory and neuroprotective properties. Recent evidence also suggests that curcumin increases cognitive performance in animal models of dementia, and this effect would be relate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d252abc1fcadd7254c61e89dfd7e2557
https://pubmed.ncbi.nlm.nih.gov/28801114

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