Development of a Dendritic Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) Contrast Agent: Synthesis, Toxicity (in Vitro) and Relaxivity (in Vitro, in Vivo) Studies

Autor: Jérôme Steibel, Anne-Isabelle Michou-Gallani, Jean-Louis Gallani, Annabelle Bertin, Delphine Felder-Flesch

Publikováno v: Bioconjugate Chemistry. 20:760-767

A new dendritic manganese(II) chelate 1 has been evaluated by in vivo (relaxivity) and in vitro (toxicity and relaxivity) experiments as a manganese enhanced magnetic resonance imaging (MEMRI) contrast agent. Also, a comparison with its corresponding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f650a766252369d8225284b478b2997c
https://doi.org/10.1021/bc8004683

Lanthanide‐Based Conjugates as Polyvalent Probes for Biological Labeling

Autor: Loïc J. Charbonnière, Raymond Ziessel, Éva Tóth, Isabelle Raynal, Marc Port, Thomas Chauvin, Nicolas Weibel, Jérôme Steibel, Stéphanie Claudel-Gillet

Publikováno v: European Journal of Inorganic Chemistry
European Journal of Inorganic Chemistry, Wiley-VCH Verlag, 2008, pp.2856-2862. ⟨10.1002/ejic.200800269⟩

International audience; A series of lanthanide complexes of [LnL(H2O)] composition, suitable for biological labeling has been studied, in which L is a strongly chelating ligand containing chromophoric bipyridylcarboxylate units and Ln = Sm, Eu, Gd, T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb314c1f716ce26a9da99de528d9ac49
https://doi.org/10.1002/ejic.200800269

Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imaging

Autor: Nelly Boehm, Nathalie Parizel, Daniel Grucker, Jérôme Steibel, Paulo Loureiro de Sousa, M. Said Ghandour, Blandine Guignard, Laura A. Harsan, Patrick Poulet

Publikováno v: Journal of Neuroscience Research. 83:392-402

Diffusion tensor magnetic resonance imaging (DT-MRI) was applied for in vivo quantification of myelin loss and regeneration. A transgenic mouse line (Oligo-TTK) expressing a truncated form of the herpes simplex virus 1 thymidine kinase gene (hsv1-tk)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6861c36f84466fd9deccd433b2117365
https://doi.org/10.1002/jnr.20742

LocalizedT2 measurements using an OSIRIS–CPMG method. Application to measurements of blood oxygenation and transverse relaxation free of diffusion effect

Autor: Izzie Jacques Namer, Patrick Poulet, Jérôme Steibel, Jacques Chambron, F. Girard

Publikováno v: NMR in Biomedicine. 7:343-348

This work presents a new method allowing localized T 2 measurements, based upon the OSIRIS scheme. A train of 180° pulses is applied after the OSIRIS preparation cycle, recording directly the transverse magnetization decay. The method was verified f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c2a2d028bae0dd7d2c3cfe796e2bacc
https://doi.org/10.1002/nbm.1940070804

In vivodynamic MR imaging of MBP-induced acute experimental allergic encephalomyelitis in Lewis rat

Autor: Izzie Jacques Namer, Y. Mauss, Jacques Chambron, Jérôme Steibel, Jean-Paul Armspach, Patrick Poulet

Publikováno v: Magnetic Resonance in Medicine. 24:325-334

A dynamic in vivo study by MRI consisting of the measurement of relaxation times and in the visualization of the BBB permeability by Gd-DOTA was performed in an MBP-induced acute EAE model of Lewis rat. Fourteen rats were immunized with an MBP/CFA mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67710c4f8f9fa1088e69a3ef6fddfff5
https://doi.org/10.1002/mrm.1910240213