Human preprocalcitonin self-antigen generates TAP-dependent and -independent epitopes triggering optimised T-cell responses toward immune-escaped tumours

Autor: Aurélie Durgeau, Yasemin Virk, Gwendoline Gros, Elodie Voilin, Stéphanie Corgnac, Fayçal Djenidi, Jérôme Salmon, Julien Adam, Vincent de Montpréville, Pierre Validire, Soldano Ferrone, Salem Chouaib, Alexander Eggermont, Jean-Charles Soria, François Lemonnier, Eric Tartour, Nathalie Chaput, Benjamin Besse, Fathia Mami-Chouaib

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Tumours can escape CD8 T-cell immunity by down-regulating antigen presentation machinery components, such as TAP. Here the authors describe tumour antigenic peptides processed by TAP-independent and -dependent pathways and show in mouse models that t

Externí odkaz: https://doaj.org/article/7f6d68fe1b834788afc4ae75e5477438

Human leukocyte antigen (HLA) class I restricted epitope discovery in yellow fewer and dengue viruses: importance of HLA binding strength.

Autor: Ole Lund, Eduardo J M Nascimento, Milton Maciel, Morten Nielsen, Mette Voldby Larsen, Claus Lundegaard, Mikkel Harndahl, Kasper Lamberth, Søren Buus, Jérôme Salmon, Thomas J August, Ernesto T A Marques

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e26494 (2011)

Epitopes from all available full-length sequences of yellow fever virus (YFV) and dengue fever virus (DENV) restricted by Human Leukocyte Antigen class I (HLA-I) alleles covering 12 HLA-I supertypes were predicted using the NetCTL algorithm. A subset

Externí odkaz: https://doaj.org/article/cb7aee930f374cffb70bcea965ca4d9c

Divergent HLA variations and heterogeneous expression but recurrent HLA loss-of- heterozygosity and common HLA-B and TAP transcriptional silencing across advanced pediatric solid cancers

Autor: Wan Ching Lim, Maria Eugenia Marques Da Costa, Karine Godefroy, Eric Jacquet, Loren Gragert, Windy Rondof, Antonin Marchais, Naima Nhiri, Davide Dalfovo, Mathias Viard, Nizar Labaied, Asif M. Khan, Philippe Dessen, Alessandro Romanel, Claudia Pasqualini, Gudrun Schleiermacher, Mary Carrington, Laurence Zitvogel, Jean-Yves Scoazec, Birgit Geoerger, Jerome Salmon

Publikováno v: Frontiers in Immunology, Vol 14 (2024)

The human leukocyte antigen (HLA) system is a major factor controlling cancer immunosurveillance and response to immunotherapy, yet its status in pediatric cancers remains fragmentary. We determined high-confidence HLA genotypes in 576 children, adol

Externí odkaz: https://doaj.org/article/b7bf7991e0734276842ecffd32168c0d

Secreted dengue virus nonstructural protein NS1 is an atypical barrel-shaped high-density lipoprotein

Autor: Jacques d'Alayer, Thomas Krey, Eric Guittet, Marie Flamand, Fasséli Coulibaly, Eric Larquet, Jérôme Salmon, Pierre Charneau, Irina Gutsche, James E. Voss, Félix A. Rey, Françoise Mégret, Myriam Ermonval

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (19), pp.8003-8008. ⟨10.1073/pnas.1017338108⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, 108 (19), pp.8003-8008. ⟨10.1073/pnas.1017338108⟩

International audience; Dengue virus (DENV) causes the major arboviral disease of the tropics, characterized in its severe forms by signs of hemorrhage and plasma leakage. DENV encodes a nonstructural glycoprotein, NS1, that associates with intracell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f041bd938d5af15435db11d67799ee6f
https://hal-pasteur.archives-ouvertes.fr/pasteur-00590815

The rabbit viral skin papillomas and carcinomas: a model for the immunogenetics of HPV-associated carcinogenesis

Autor: Gérard Orth, Jérôme Salmon, Françoise Breitburd

Publikováno v: Clinics in dermatology. 15(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b12ef93329a24e97c4b491d036d55901
https://pubmed.ncbi.nlm.nih.gov/9167908