Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jérôme Flakowski"'
Autor:
Ruud van Zessen, Yue Li, Lucile Marion-Poll, Nicolas Hulo, Jérôme Flakowski, Christian Lüscher
Publikováno v:
eLife, Vol 10 (2021)
Locomotor sensitization (LS) is an early behavioral adaptation to addictive drugs, driven by the increase of dopamine in the Nucleus Accumbens (NAc). However, the effect on accumbal population activity remains elusive. Here, we used single-cell calci
Externí odkaz:
https://doaj.org/article/3f96f96faee244bf9b02d04ddb6b936c
Publikováno v:
Biological psychiatry, Vol. 90, No 12 (2021) pp. 808-818
Background Activation of the mesolimbic dopamine system is positively reinforcing. After repeated activation, some individuals develop compulsive reward-seeking behavior, which is a core symptom of addiction. However, the underlying neural mechanism
Autor:
Fei Deng, Yulong Li, Jin-Xia Wan, Jérôme Flakowski, Vincent Pascoli, Christian Lüscher, Linda D. Simmler, Katherine M. Nautiyal, Yue Li, Ruud van Zessen
Publikováno v:
Science, Vol. 373, No 6560 (2021) pp. 1252-1256
Prevention of compulsive cocaine taking Over time, about 20% of chronic cocaine users lose control and become addicted. There are indications that the differential efficacy of the brain serotonin (5-HT) system may be involved in the vulnerability to
Autor:
Ridouane Achargui, Ruud van Zessen, Michael Loureiro, Jérôme Flakowski, Vincent Pascoli, Agnès Hiver, Masaya Harada, Christian Lüscher
Publikováno v:
Nature, Vol. 564, No 7736 (2018) pp. 366-371
Activation of the mesolimbic dopamine system reinforces goal-directed behaviours. With repetitive stimulation-for example, by chronic drug abuse-the reinforcement may become compulsive and intake continues even in the face of major negative consequen
Locomotor sensitization (LS) is an early behavioral adaptation to addictive drugs, driven by the increase of dopamine in the Nucleus Accumbens (NAc). However, the effect on accumbal population activity remains elusive. Here we used single cell calciu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e47df21a252b4adb73789da07e7d5705
https://doi.org/10.1101/2021.01.28.428587
https://doi.org/10.1101/2021.01.28.428587
Autor:
Yue Li, Lucile Marion-Poll, Jérôme Flakowski, Ruud van Zessen, Christian Lüscher, Nicolas Hulo
Publikováno v:
eLife, Vol. 10 (2021) P. e66048
eLife, Vol 10 (2021)
eLife
eLife, Vol 10 (2021)
eLife
Locomotor sensitization (LS) is an early behavioral adaptation to addictive drugs, driven by the increase of dopamine in the Nucleus Accumbens (NAc). However, the effect on accumbal population activity remains elusive. Here, we used single-cell calci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb8483a5701a516c1c25af226be4a26
https://archive-ouverte.unige.ch/unige:158151
https://archive-ouverte.unige.ch/unige:158151
Publikováno v:
J Neurosci
Journal of Neuroscience, Vol. 40, No 39 (2020) pp. 7489-7509
Journal of Neuroscience, Vol. 40, No 39 (2020) pp. 7489-7509
Dopamine (DA) neurons of the VTA track cues and rewards to generate a reward prediction error signal during Pavlovian conditioning. Here we explored how these neurons respond to a self-paced, operant task in freely moving mice. The animal could trigg
Addicted individuals compulsively seek drugs. Cortico-striatal projections have been implicated in persevering to seek rewards even when punished. The temporo-spatial determinants of the activity underlying the compulsive reward seeking however remai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::727a84eb0a6ea7ec3d14e504588d7920
https://doi.org/10.1101/789495
https://doi.org/10.1101/789495
Autor:
Christian Lüscher, Thomas Stefanelli, Vincent Pascoli, Ridouane Achargui, Ruud van Zessen, Michael Loureiro, Jérôme Flakowski
Publikováno v:
Science, Vol. 364, No 6444 (2019) pp. 991-995
This is safe, you can eat it Social transmission of food preference is a model for studying nonspatial memory. In mice, a signal that food is safe to eat is transmitted by its smell along with molecules in the breath of a conspecific. How the odor it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f190c51bb47d02c3c81d926c06ee7d
https://archive-ouverte.unige.ch/unige:124244
https://archive-ouverte.unige.ch/unige:124244