Výsledky vyhledávání - "Jérôme Feldmann"

Primary hemophagocytic syndromes point to a direct link between lymphocyte cytotoxicity and homeostasis

Autor: Gaël Ménasché, Geneviève de Saint Basile, Jérôme Feldmann, Alain Fischer

Publikováno v: Immunological Reviews. 203:165-179

Hemophagocytic syndrome (HS) is a severe and often fatal syndrome resulting from potent and uncontrolled activation and proliferation of T-lymphocytes, leading to excessive macrophage activation and multiple deleterious effects. The onset of HS chara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842d5acb9366d3ba659b54e10157fef6
https://doi.org/10.1111/j.0105-2896.2005.00224.x

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Griscelli Syndrome: Characterization of a New Mutation and Rescue of T-Cytotoxic Activity by Retroviral Transfer of RAB27A Gene

Autor: Erasmo Barbante Casella, Cristina Miuki Abe Jacob, Fabíola Attié de Castro, Gaël Ménasché, João C. S. Bizario, Lilian Maria Cristofani, Júlio César Voltarelli, Geneviève de Saint-Basile, Jérôme Feldmann, Enilza Maria Espreáfico

Publikováno v: Journal of Clinical Immunology. 24:397-410

Griscelli syndrome (GS) is caused by mutations in the MYO5A (GS1), RAB27A (GS2), or MLPH (GS3) genes, all of which lead to a similar pigmentary dilution. In addition, GS1 patients show primary neurological impairment, whereas GS2 patients present imm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa9829334338737052d0a0e20ce7da8
https://doi.org/10.1023/b:joci.0000029119.83799.cb

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Defective CTLA-4 cycling pathway in Chediak–Higashi syndrome: A possible mechanism for deregulation of T lymphocyte activation

Autor: Geneviève de Saint Basile, Malika Benkerrou, Alain Fischer, Jérôme Feldmann, Philippe Bousso, Franck J. Barrat, Françoise Le Deist

Publikováno v: Proceedings of the National Academy of Sciences. 96:8645-8650

Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4, also known as CD152) has been shown to play a major role in the regulation of T cell activation. Its membrane expression is highly regulated by endocytosis and trafficking through the secretory lys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd8108bb1349205faa525e2b610da44b
https://doi.org/10.1073/pnas.96.15.8645

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Munc13-4, un nouvel effecteur indispensable à la sécrétion des granules cytotoxiques

Autor: Le Deist F, Jérôme Feldmann, A Fischer, de Saint Basile G

Publikováno v: médecine/sciences. 20:144-146

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00f6e0a2c652cafa0ab8702667c38b17
https://doi.org/10.1051/medsci/2004202144

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HIV-1 Virological Synapse: Live Imaging of Transmission

Autor: Jérôme Feldmann, Olivier Schwartz

Publikováno v: Viruses
Viruses, MDPI, 2010, Special Issue "Transmission of Retroviruses across Virological Synapses", 2 (8), pp.1666-1680. ⟨10.3390/v2081666⟩
Viruses, 2010, Special Issue "Transmission of Retroviruses across Virological Synapses", 2 (8), pp.1666-1680. ⟨10.3390/v2081666⟩
Viruses, Vol 2, Iss 8, Pp 1666-1680 (2010)
Viruses; Vol 2

International audience; A relatively new aspect of HIV-1 biology is the ability of the virus to infect cells by direct cellular contacts across a specialized structure, the virological synapse. This process was recently described through live cell im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f2564b02ba03ca35fac43b7d96c696d
https://hal-pasteur.archives-ouvertes.fr/pasteur-01372500

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Direct relationship between virus load and systemic immune activation in HIV-2 infection

Autor: Tao Dong, Aleksandra Leligdowicz, Matthew Cotten, Sarah Rowland-Jones, Assan Jaye, Andrew J. McMichael, Hilton Whittle, Jérôme Feldmann

Publikováno v: The Journal of infectious diseases. 201(1)

Immune activation is a hallmark of disease progression in human immunodeficiency virus (HIV) type 1 (HIV1) and HIV type 2 (HIV-2) infection. However, the relationship between viremia and systemic immune activation is unclear. We assessed the relation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::080eb2428e12e43674b6bd4c24369e51
https://pubmed.ncbi.nlm.nih.gov/19938978

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Simultaneous cell-to-cell transmission of human immunodeficiency virus to multiple targets through polysynapses

Autor: Steve Wietgrefe, Nathalie Sol-Foulon, Marie Christine Prevost, Ashley T. Haase, Françoise Porrot, Stéphanie Guadagnini, Dominika Rudnicka, Olivier Schwartz, Jérôme Feldmann, Jérôme Estaquier

Publikováno v: Journal of Virology
Journal of Virology, 2009, 83 (12), pp.6234-46. ⟨10.1128/JVI.00282-09⟩
Journal of Virology, American Society for Microbiology, 2009, 83 (12), pp.6234-46. ⟨10.1128/JVI.00282-09⟩
Journal of Virology; Vol 83

Human immunodeficiency virus type 1 (HIV-1) efficiently propagates through cell-to-cell contacts, which include virological synapses (VS), filopodia, and nanotubes. Here, we quantified and characterized further these diverse modes of contact in lymph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5d38e6ae8ff11f2ab7717b0fa1dc96
https://hal-pasteur.archives-ouvertes.fr/pasteur-00458065

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Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4

Autor: Gaël Ménasché, Geneviève de Saint Basile, Chen-Hsuan Ho, Alain Fischer, Jérôme Feldmann, Maryse Romao, Mériem Garfa, Mickaël M. Ménager, Perrine Knapnougel, Graça Raposo

Publikováno v: Nature Immunology
Nature Immunology, Nature Publishing Group, 2007, 8 (3), pp.257-267. ⟨10.1038/ni1431⟩
Nature Immunology, 2007, 8 (3), pp.257-267. ⟨10.1038/ni1431⟩

International audience; Cytotoxic T lymphocytes and natural killer cells exert their cytotoxic activity through the polarized secretion of cytotoxic granules at the immunological synapse. Rab27a and hMunc13-4 are critical effectors of the exocytosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26749fd88f529e2db9976c4d59f1e2a2
https://www.hal.inserm.fr/inserm-02440339

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Severe and progressive encephalitis as a presenting manifestation of a novel missense perforin mutation and impaired cytolytic activity

Autor: Gaël Ménasché, Geneviève de Saint Basile, Françoise Le Deist, Brigitte Bader-Meunier, Laurence Le Clainche, Marc Tardieu, Isabelle Callebaut, Alain Fischer, Véronique Minard-Colin, Jérôme Feldmann

Publikováno v: Blood
Blood, American Society of Hematology, 2005, 105, pp.2658-2663. 〈10.1182/blood-2004-09-3590.〉
Blood, American Society of Hematology, 2005, 105 (7), pp.2658-2663. ⟨10.1182/blood-2004-09-3590⟩
Blood, American Society of Hematology, 2005, 105, pp.2658-2663. ⟨10.1182/blood-2004-09-3590.⟩
Blood, 2005, 105 (7), pp.2658-2663. ⟨10.1182/blood-2004-09-3590⟩

International audience; Mutations in the perforin gene cause familial hemophagocytic lymphohistiocytosis (FHL). The first symptoms of FHL are usually intractable fever, hepatosplenomegaly, and pancytopenia. Most FHL patients subsequently develop cent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0eb206e230f62ff464c29a113aa488f
https://hal.archives-ouvertes.fr/hal-00021627

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