Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jérôme E. Lafont"'
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Epigenetics defines the modifications of the genome that do not involve a change in the nucleotide sequence of DNA. These modifications constitute a mechanism of gene regulation poorly explored in the context of cartilage physiology. They are now int
Externí odkaz:
https://doaj.org/article/f3da471a4f974190921ac2923e6604bf
Autor:
Alexandre Dufour, Jérôme E. Lafont, Marie Buffier, Michaël Verset, Angéline Cohendet, Hugues Contamin, Joachim Confais, Sharanya Sankar, Marc Rioult, Emeline Perrier-Groult, Frédéric Mallein-Gerin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Articular cartilage is built by chondrocytes which become less active with age. This declining function of the chondrocytes, together with the avascular nature of the cartilage, impedes the spontaneous healing of chondral injuries. These les
Externí odkaz:
https://doaj.org/article/b9869d987c60479f81ee8759550420fe
Autor:
Hugo Fabre, Marielle Pasdeloup, Jérôme E. Lafont, Elisabeth Aubert-Foucher, Emeline Perrier-Groult, Frédéric Mallein-Gerin
Publikováno v:
Stem Cells and Regenerative Medicine
Type II collagen is the major collagen protein in cartilage, synthesized as precursor forms (procollagens). Several splice variants of the gene encoding type II procollagen have been identified such as IIA and IIB isoforms. Interestingly, a shift fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c100d9ad94cabed42d8049ec34895396
https://doi.org/10.3233/bhr210008
https://doi.org/10.3233/bhr210008
Autor:
Angéline Cohendet, Sharanya Sankar, Frédéric Mallein-Gerin, Marie Buffier, Jérôme E. Lafont, Marika Rioult, Michaël Verset, Hugues Contamin, Emeline Perrier-Groult, Alexandre Dufour, Joachim Confais
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, ⟨10.1038/s41598-021-83208-x⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports, Nature Publishing Group, 2021, ⟨10.1038/s41598-021-83208-x⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Articular cartilage is built by chondrocytes which become less active with age. This declining function of the chondrocytes, together with the avascular nature of the cartilage, impedes the spontaneous healing of chondral injuries. These lesions can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08641d49f209967621d80b8f9ab1f67
https://hal.archives-ouvertes.fr/hal-03357292/file/41598_2021_Article_83208.pdf
https://hal.archives-ouvertes.fr/hal-03357292/file/41598_2021_Article_83208.pdf
Autor:
Frederic Mallein-Gerin, Martine Cohen-Solal, Marielle Pasdeloup, Eric Haÿ, Hang-Korng Ea, S. Moustaghfir, R. Schuele, Jérôme E. Lafont
Publikováno v:
Revue du Rhumatisme. 88:A156
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af270935acf71ceebc8082c68ef5203b
https://doi.org/10.1016/j.rhum.2021.10.246
https://doi.org/10.1016/j.rhum.2021.10.246
Autor:
A. Dufour, Marielle Pasdeloup, Christine Oger-Desfeux, Elisabeth Aubert-Foucher, Frederic Mallein-Gerin, Elvire Servien, Emeline Perrier-Groult, Jérôme E. Lafont, G. Vaz, Sébastien Lustig, A. Durand
Publikováno v:
Revue du Rhumatisme. 87:A208
Introduction L’arthrose est une pathologie degenerative des articulations qui est associee a une alteration de la production de la matrice du cartilage par les chondrocytes. Nous avons etudie le role de la Lysine-Specific Demethylase-1 (LSD1), une
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cca7dcde092b4215fd02881913bca200
https://doi.org/10.1016/j.rhum.2020.10.363
https://doi.org/10.1016/j.rhum.2020.10.363
The chondrocyte is solely responsible for synthesis and maintenance of the resilient articular cartilage matrix that gives this load-bearing tissue its mechanical integrity. When the differentiated cell phenotype is lost, the matrix becomes compromis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d5060c4058bfa1d2ef8c8a702c6830
https://doi.org/10.1074/jbc.m707729200
https://doi.org/10.1074/jbc.m707729200
Publikováno v:
Arthritis Research & Therapy
In a chronically hypoxic tissue such as cartilage, adaptations to hypoxia do not merely include cell survival responses, but also promotion of its specific function. This review will focus on describing such hypoxia-mediated chondrocyte function, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f37a66dbb26173978344ea5b68fddfb
https://ora.ox.ac.uk/objects/uuid:83c48a8a-e7e0-4b75-a89b-12b06a5f29ef
https://ora.ox.ac.uk/objects/uuid:83c48a8a-e7e0-4b75-a89b-12b06a5f29ef
Publikováno v:
Osteoarthritis and Cartilage. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d20bce0cc0541ab7227ca219572631
Autor:
Sylvain Pichat, Philippe Telouk, Emmanuelle Albalat, Vincent Balter, Melanie Simon, Victor P. Bondanese, Francis Albarède, Philippe Oger, Aline Lamboux, Jean-Marc Vanacker, Jérôme E. Lafont
Publikováno v:
Metallomics
Metallomics, Royal Society of Chemistry, 2016, 8 (11), pp.1177-1184. ⟨10.1039/c6mt00102e⟩
Metallomics, 2016, 8 (11), pp.1177-1184. ⟨10.1039/c6mt00102e⟩
Metallomics, Royal Society of Chemistry, 2016, 8 (11), pp.1177-1184. ⟨10.1039/c6mt00102e⟩
Metallomics, 2016, 8 (11), pp.1177-1184. ⟨10.1039/c6mt00102e⟩
Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer, with increasing incidence worldwide. The unrestrained proliferation of tumour cells leads to tumour hypoxia which in turn promotes cancer aggressiveness. While changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4cd0dd0ffa6daab7291c73831b40419
https://hal.archives-ouvertes.fr/hal-02132068
https://hal.archives-ouvertes.fr/hal-02132068