High-Resolution Mass Spectrometry Associated with Data Mining Tools for the Detection of Pollutants and Chemical Characterization of Honey Samples

Autor: Christophe Junot, Mylène Marie, Fanny Leroux, Jérôme Cotton, Céline Ducruix, Jean-Claude Tabet, Bruno Corman, Simon Broudin

Publikováno v: Journal of Agricultural and Food Chemistry
Journal of Agricultural and Food Chemistry, American Chemical Society, 2014, 62 (46), pp.11335--11345. ⟨10.1021/jf504400c⟩
Journal of Agricultural and Food Chemistry, 2014, 62 (46), pp.11335--11345. ⟨10.1021/jf504400c⟩

Analytical methods for food control are mainly focused on restricted lists of well-known contaminants. This paper shows that liquid chromatography-high-resolution mass spectrometry (LC/ESI-HRMS) associated with the data mining tools developed for met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ff50da4ee467eb76b140a7513e55cf
https://doi.org/10.1021/jf504400c

Data fusion between high resolution H-1-NMR and mass spectrometry: a synergetic approach to honey botanical origin characterization

Autor: Bruno Corman, Marc Spiteri, Marion Poirel, Douglas N. Rutledge, Jérôme Cotton, Eric Jamin, Michele Lees, Elodie Dubin

Publikováno v: Analytical and Bioanalytical Chemistry
Analytical and Bioanalytical Chemistry, Springer Verlag, 2016, 408 (16), pp.4389-4401. ⟨10.1007/s00216-016-9538-4⟩

A data fusion approach was applied to a commercial honey data set analysed by (1)H-nuclear magnetic resonance (NMR) 400 MHz and liquid chromatography-high resolution mass spectrometry (LC-HRMS). The latter was performed using two types of mass spectr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166e7d5943f644ed66b084e56eeaf8c5
https://hal.archives-ouvertes.fr/hal-01532577

First pass intestinal and liver metabolism of paracetamol in a microfluidic platform coupled with a mathematical modeling as a means of evaluating ADME processes in humans

Autor: Jean Matthieu, Prot, Luis, Maciel, Thibault, Bricks, Franck, Merlier, Jérôme, Cotton, Patrick, Paullier, Fréderic Yves, Bois, Eric, Leclerc

Publikováno v: Biotechnology and bioengineering. 111(10)

We developed a microfluidic platform to investigate paracetamol intestinal and liver first pass metabolism. This approach was coupled with a mathematical model to estimate intrinsic in vitro parameters and to predict in vivo processes. The kinetic mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9051f4dd5a4b70e95a1244548a20497b
https://pubmed.ncbi.nlm.nih.gov/24954399

Evaluation of a liver microfluidic biochip to predict in vivo clearances of seven drugs in rats

Autor: Jérôme Cotton, Régis Baudoin, Sébastien Jacques, Audrey Legendre, Eric Leclerc, Frédéric Y. Bois

Publikováno v: Journal of Pharmaceutical Sciences
Journal of Pharmaceutical Sciences, Wiley, 2014, 103 (2), pp.706-718. ⟨10.1002/jps.23796⟩

We investigated metabolic clearances of phenacetin, midazolam, propranolol, paracetamol, tolbutamide, caffeine, and dextromethorphan by primary rat hepatocytes cultivated in microfluidic biochips. The levels of mRNA of the HNF4 α, PXR , AHR, CYP3A1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c90874862db29fe62fbf05ad5b3a29
https://pubmed.ncbi.nlm.nih.gov/24338834