Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jérôme Cluzeau"'
Autor:
Boris Peklar, Franc Perdih, Damjan Makuc, Janez Plavec, Jérôme Cluzeau, Zoran Kitanovski, Zdenko Časar
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1641 (2022)
Glasdegib is a recently approved drug for the treatment of acute myeloid leukemia. It is formulated and marketed in monomaleate salt form. In our investigation, we were able to prepare a glasdegib dimaleate form, which could, in theory, exist in doub
Externí odkaz:
https://doaj.org/article/ded90dd75aaa4c82871e27805bb6b088
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62250 (2013)
Employing DERA (2-deoxyribose-5-phosphate aldolase), we developed the first whole-cell biotransformation process for production of chiral lactol intermediates useful for synthesis of optically pure super-statins such as rosuvastatin and pitavastatin.
Externí odkaz:
https://doaj.org/article/62d7b09ebfa040f883a5332a49783f78
Publikováno v:
Organic Process Research & Development. 15:622-630
A chemoselective biocatalytic procedure for the synthesis of (4R,6S)-4-(tert-butyldimethylsilyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-2-one, a key lactonized statin side chain intermediate, from its acetate precursor is described. The presented me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d371594af443111e30b90c435176ba8
https://doi.org/10.1021/op100341m
https://doi.org/10.1021/op100341m
Publikováno v:
Tetrahedron Letters. 39:5775-5778
(2S,4RS)-Boc-4-cyanoglutamate γ-methyl ester (ee = 95%) and (2S)-Boc-2-amino-4-bis(cyano)butyrate (ee = 96%) were synthesised in respectively 43% and 40% overall yields by addition of sodium malonate derivatives onto Boc-dehydroalanine methyl ester
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55ba4e013eb1e682f7283c923d98db62
https://doi.org/10.1016/s0040-4039(98)01207-6
https://doi.org/10.1016/s0040-4039(98)01207-6
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62250 (2013)
PLoS ONE
PLoS ONE
Employing DERA (2-deoxyribose-5-phosphate aldolase), we developed the first whole-cell biotransformation process for production of chiral lactol intermediates useful for synthesis of optically pure super-statins such as rosuvastatin and pitavastatin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df722a9d6964f2e82537b1c86c065cd
https://doi.org/10.1371/journal.pone.0062250
https://doi.org/10.1371/journal.pone.0062250
Autor:
Kenji Tomita, Shinya Oishi, Jérôme Cluzeau, Hiroaki Ohno, Jean-Marc Navenot, Zi-xuan Wang, Stephen C. Peiper, Miki Akamatsu, Nobutaka Fujii
Publikováno v:
Journal of Medicinal Chemistry; Jul2007, Vol. 50 Issue 14, p3222-3228, 7p
Autor:
Damien Boeglin, Fadi F. Hamdan, Rosa E. Melendez, Jérôme Cluzeau, Andre Laperriere, Madeleine Héroux, Michel Bouvier, William D. Lubell
Publikováno v:
Journal of Medicinal Chemistry; Mar2007, Vol. 50 Issue 6, p1401-1408, 8p
Autor:
Satoshi Ueda, Shinya Oishi, Zi-xuan Wang, Takanobu Araki, Hirokazu Tamamura, Jérôme Cluzeau, Hiroaki Ohno, Shuichi Kusano, Hideki Nakashima, John O. Trent, Stephen C. Peiper, Nobutaka Fujii
Publikováno v:
Journal of Medicinal Chemistry; Jan2007, Vol. 50 Issue 2, p192-198, 7p