Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Jérôme Ausseil"'
Autor:
Fabienne Briand-Mésange, Isabelle Gennero, Juliette Salles, Stéphanie Trudel, Lionel Dahan, Jérôme Ausseil, Bernard Payrastre, Jean-Pierre Salles, Hugues Chap
Publikováno v:
Molecules, Vol 29, Iss 15, p 3694 (2024)
2-arachidonoylglycerol (2-AG) is the most abundant endocannabinoid (EC), acting as a full agonist at both CB1 and CB2 cannabinoid receptors. It is synthesized on demand in postsynaptic membranes through the sequential action of phosphoinositide-speci
Externí odkaz:
https://doaj.org/article/9abc783c17c548a88592a6d84b2648a0
Autor:
Nissrine Ballout, Agnès Boullier, Walaa Darwiche, Katia Ait-Mohand, Eric Trécherel, Théo Gallégo, Cathy Gomila, Linda Yaker, Isabelle Gennero, José Kovensky, Jérôme Ausseil, Sylvestre Toumieux
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1512 (2023)
Bone fracture healing is a complex biological process involving four phases coordinated over time: hematoma formation, granulation tissue formation, bony callus formation, and bone remodelling. Bone fractures represent a significant health problem, p
Externí odkaz:
https://doaj.org/article/d6163f796d494d689c2dc1e66048285e
Autor:
Linda Yaker, Abdellah Tebani, Céline Lesueur, Chloé Dias, Vincent Jung, Soumeya Bekri, Ida Chiara Guerrera, Saïd Kamel, Jérôme Ausseil, Agnès Boullier
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Background: Vascular calcification (VC) is a cardiovascular complication associated with a high mortality rate among patients with diseases such as atherosclerosis and chronic kidney disease. During VC, vascular smooth muscle cells (VSMCs) undergo an
Externí odkaz:
https://doaj.org/article/0ccc1d16ef5d4414944a8c8934483ed7
Autor:
Michaël Hocquemiller, Kim M. Hemsley, Meghan L. Douglass, Sarah J. Tamang, Daniel Neumann, Barbara M. King, Helen Beard, Paul J. Trim, Leanne K. Winner, Adeline A. Lau, Marten F. Snel, Cathy Gomila, Jérôme Ausseil, Xin Mei, Laura Giersch, Mark Plavsic, Ralph Laufer
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 174-187 (2020)
Patients with mucopolysaccharidosis type IIIA (MPS IIIA) lack the lysosomal enzyme sulfamidase (SGSH), which is responsible for the degradation of heparan sulfate (HS). Build-up of undegraded HS results in severe progressive neurodegeneration for whi
Externí odkaz:
https://doaj.org/article/dc201b70e27746bcae02d970deb12fca
Autor:
Mathilde Bergamelli, Hélène Martin, Mélinda Bénard, Jérôme Ausseil, Jean-Michel Mansuy, Ilse Hurbain, Maïlys Mouysset, Marion Groussolles, Géraldine Cartron, Yann Tanguy le Gac, Nathalie Moinard, Elsa Suberbielle, Jacques Izopet, Charlotte Tscherning, Graça Raposo, Daniel Gonzalez-Dunia, Gisela D’Angelo, Cécile E. Malnou
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Extracellular vesicles (EVs) have increasingly been recognized as key players in a wide variety of physiological and pathological contexts, including during pregnancy. Notably, EVs appear both as possible biomarkers and as mediators involved in the c
Externí odkaz:
https://doaj.org/article/3c6c7a0436584794b1360c2aaacebf18
Autor:
Reiner F. Haseloff, Stephanie Trudel, Ramona Birke, Michael Schümann, Eberhard Krause, Cathy Gomila, Jean-Michel Heard, Ingolf E. Blasig, Jérôme Ausseil
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Mucopolysaccharidosis type I (MPS I) is caused by a deficiency of the lysosomal hydroxylase alpha-l-iduronidase (IDUA). The resulting accumulation of dermatan and heparan sulfate induces intellectual disabilities and pre-mature death, and only a few
Externí odkaz:
https://doaj.org/article/ce0c544621ed42069de208e4428cd9a5
Autor:
Ali Mansour, Walaa Darwiche, Linda Yaker, Sophie Da Nascimento, Cathy Gomila, Claire Rossi, Vincent Jung, Pascal Sonnet, Saïd Kamel, Ida Chiara Guerrera, Agnès Boullier, Jérôme Ausseil
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
ObjectiveVascular calcification (VC) is an active process during which vascular smooth muscle cells (VSMCs) undergo an osteogenic switch and release extracellular vesicles (EVs). In turn, the EVs serve as calcification foci via interaction with type
Externí odkaz:
https://doaj.org/article/8682840f708b49b0aec1cfd46773d57f
Autor:
Abdellah Tebani, Lenaig Abily-Donval, Isabelle Schmitz-Afonso, Bénédicte Héron, Monique Piraud, Jérôme Ausseil, Farid Zerimech, Bruno Gonzalez, Stéphane Marret, Carlos Afonso, Soumeya Bekri
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-14 (2018)
Abstract Background Metabolomics represent a valuable tool to recover biological information using body fluids and may help to characterize pathophysiological mechanisms of the studied disease. This approach has not been widely used to explore inheri
Externí odkaz:
https://doaj.org/article/2a82a7d9a17a4d6fa0fa6281709f1a3a
Publikováno v:
Toxins, Vol 12, Iss 12, p 811 (2020)
Vascular calcification (VC) is a cardiovascular complication associated with a high mortality rate, especially in patients with diabetes, atherosclerosis or chronic kidney disease (CKD). In CKD patients, VC is associated with the accumulation of urem
Externí odkaz:
https://doaj.org/article/729834fc9c91410caf0452f04d47d033
Autor:
Abdellah Tebani, Lenaig Abily-Donval, Isabelle Schmitz-Afonso, Monique Piraud, Jérôme Ausseil, Farid Zerimech, Carine Pilon, Tony Pereira, Stéphane Marret, Carlos Afonso, Soumeya Bekri
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 2, p 446 (2019)
Metabolic phenotyping is poised as a powerful and promising tool for biomarker discovery in inherited metabolic diseases. However, few studies applied this approach to mcopolysaccharidoses (MPS). Thus, this innovative functional approach may unveil c
Externí odkaz:
https://doaj.org/article/e72f4059f4304ec4b7a3912b9d62686e