Lipophilicity trends upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl groups

Autor: Benjamin Jeffries, Zhong Wang, Robert I. Troup, Anaïs Goupille, Jean-Yves Le Questel, Charlene Fallan, James S. Scott, Elisabetta Chiarparin, Jérôme Graton, Bruno Linclau

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 2141-2150 (2020)

A systematic comparison of lipophilicity modulations upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl substituents, at a single carbon atom, is provided using directly comparable, and easily accessible model compounds. In addition, comparis

Externí odkaz: https://doaj.org/article/5644f5bd717b453ba99d0547aa77d2b0

Similar Comparative Low and High Doses of Deltamethrin and Acetamiprid Differently Impair the Retrieval of the Proboscis Extension Reflex in the Forager Honey Bee (Apis mellifera)

Autor: Steeve H. Thany, Céline M. Bourdin, Jérôme Graton, Adèle D. Laurent, Monique Mathé-Allainmat, Jacques Lebreton, Jean-Yves le Questel

Publikováno v: Insects, Vol 6, Iss 4, Pp 805-814 (2015)

In the present study, the effects of low (10 ng/bee) and high (100 ng/bee) doses of acetamiprid and deltamethrin insecticides on multi-trial learning and retrieval were evaluated in the honey bee Apis mellifera. After oral application, acetamiprid an

Externí odkaz: https://doaj.org/article/d99d195928b4483194fff70b8f4b53ca

Lipophilicity trends upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl groups

Autor: Robert I. Troup, Zhong Wang, Jérôme Graton, Jean-Yves Le Questel, Bruno Linclau, Anaïs Goupille, Benjamin Jeffries, Charlene Fallan, James S. Scott, Elisabetta Chiarparin

Publikováno v: Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 2141-2150 (2020)
Beilstein Journal of Organic Chemistry, Beilstein-Institut, 2020, 16, pp.2141-2150. ⟨10.3762/bjoc.16.182⟩

International audience; A systematic comparison of lipophilicity modulations upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl substituents, at a single carbon atom, is provided using directly comparable, and easily accessible model compound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb1c4c24fbd7280f871dfd73fe03deaa
http://europepmc.org/articles/PMC7476584

Towards a Stronger Halogen Bond Involving Astatine: Unexpected Adduct with Bu 3 PO Stabilized by Hydrogen Bonding

Autor: Jérôme Graton, Rémi Maurice, Lu Liu, Julie Champion, Ning Guo, Gilles Montavon, Nicolas Galland

Publikováno v: Chem.Eur.J.
Chem.Eur.J., 2020, 26 (17), pp.3713-3717. ⟨10.1002/chem.201905389⟩
Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2020, 26 (17), pp.3713-3717. ⟨10.1002/chem.201905389⟩

International audience; The halogen bond is a powerful tool for the molecular design and pushing the limits of its strength is of major interest. Bearing the most potent halogen‐bond donor atom, astatine monoiodide (AtI) was recently successfully p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf075b8afc806700886ac83cdae8a0aa
https://doi.org/10.1002/chem.201905389

Identification of sulfonamide compounds active on the insect nervous system: Molecular modeling, synthesis and biological evaluation

Autor: Balaji, Selvam, Elodie, Landagaray, Alison, Cartereau, Adèle D, Laurent, Jérôme, Graton, Jacques, Lebreton, Steeve H, Thany, Monique, Mathé-Allainmat, Jean-Yves, Le Questel

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 80:129124

Insect nicotinic acetylcholine receptors (nAChRs) are a recognized target for insecticide design. In this work, we have identified, from a structure-based approach using molecular modeling tools, ligands with potential selective activity for pests ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd342b4a3dc6e84629bcc476dbd88aa1
https://doi.org/10.1016/j.bmcl.2023.129124