Optimization of RNA extraction methods from human metabolic tissue samples of the COMET biobank

Autor: Agathe Nouvel, Jonas Laget, Flore Duranton, Jérémy Leroy, Caroline Desmetz, Marie-Dominique Servais, Nathalie de Préville, Florence Galtier, David Nocca, Nicolas Builles, Sandra Rebuffat, Anne-Dominique Lajoix

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract Constitution of biobank of human tissues requires careful handling and storage of biological material, to guarantee the quality of samples. Tissue preparation is also critical for further applications such as transcriptomic profiling. In thi

Externí odkaz: https://doaj.org/article/5d75a91b01c2481587cde25701b167d8

S-Ethyl-Isothiocitrullin-Based Dipeptides and 1,2,4-Oxadiazole Pseudo-Dipeptides: Solid Phase Synthesis and Evaluation as NO Synthase Inhibitors

Autor: Hernandez, Elodie Mauchauffée, Jérémy Leroy, Jihanne Chamcham, Abdelaziz Ejjoummany, Manon Maurel, Lionel Nauton, Booma Ramassamy, Karima Mezghenna, Jean-Luc Boucher, Anne-Dominique Lajoix, Jean-François

Publikováno v: Molecules; Volume 28; Issue 13; Pages: 5085

We previously reported dipeptidomimetic compounds as inhibitors of neuronal and/or inducible NO synthases (n/iNOS) with significant selectivity against endothelial NOS (eNOS). They were composed of an S-ethylisothiocitrullin-like moiety linked to an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::4256ce4966bbb6b3902c333f54726652

Reduced production of isoprostanes by peri-pancreatic adipose tissue from Zucker fa/fa rats as a new mechanism for β-cell compensation in insulin resistance and obesity

Autor: Jonas Laget, Claire Vigor, Agathe Nouvel, Amandine Rocher, Jérémy Leroy, Laura Jeanson, Guillaume Reversat, Camille Oger, Jean-Marie Galano, Thierry Durand, Sylvie Péraldi-Roux, Jacqueline Azay-Milhau, Anne-Dominique Lajoix

Publikováno v: Free radical biologymedicine. 182

During early stages of type 2 diabetes, named prediabetes, pancreatic β-cells compensate for insulin resistance through increased insulin secretion in order to maintain normoglycemia. Obesity leads to the development of ectopic fat deposits, among w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47eca9c2a69ffe18fd1069f8b2a658e4
https://pubmed.ncbi.nlm.nih.gov/35227851

Glucose-based spiro-oxathiazoles as in vivo anti-hyperglycemic agents through glycogen phosphorylase inhibition

Autor: Cédric Duret, Sophie Balzarin, Didier Tousch, Bálint Kónya, Michel Tournier, Pierre Petit, Pál Gergely, Paolo Larini, David Goyard, Jean-Pierre Praly, Jérémy Leroy, Tibor Docsa, Jacqueline Azay-Milhau, Patrick Maurel, Katalin Czifrák, Sébastien Vidal, Fanny Demontrond, László Somsák

Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2020, 18 (5), pp.931-940. ⟨10.1039/C9OB01190K⟩
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2020, 18 (5), pp.931-940. ⟨10.1039/c9ob01190k⟩
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2020, 18 (5), pp.931-940. ⟨10.1039/C9OB01190K⟩

International audience; The design of glycogen phosphorylase (GP) inhibitors targeting the catalytic site of the enzyme is a promising strategy for a better control of hyperglycaemia in the context of type 2 diabetes. Glucopyranosylidene-spiro-hetero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbaea3c59453ca87bdeda8c62fcedb61
https://hal.univ-grenoble-alpes.fr/hal-02942989/file/Fulltext_Vidal_Revision.pdf

Chemical Analysis and Antihyperglycemic Activity of an Original Extract from Burdock Root (Arctium lappa)

Autor: Anne-Dominique Lajoix, Michel Tournier, Marie Faucanie, Hugues Chevassus, Jérémy Leroy, Luc P. R. Bidel, Guillaume Cazals, Jacqueline Azay-Milhau, Karine Ferrare, Didier Tousch

Publikováno v: Journal of Agricultural and Food Chemistry
Journal of Agricultural and Food Chemistry, American Chemical Society, 2014, 62 (31), pp.7738-7745. ⟨10.1021/jf500926v⟩

In the present study, we obtained a dried burdock root extract (DBRE) rich in caffeoylquinic acids derivatives. We performed the chemical characterization of DBRE and explored its antihyperglycemic potential in both in vitro and in vivo experiments.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35358bab4bad7541d482b790ff9627be
https://hal.archives-ouvertes.fr/hal-01268818