Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jérémy C. Santamaria"'
Autor:
Alexia Borelli, Jérémy C. Santamaria, Cloé Zamit, Cécile Apert, Jessica Chevallier, Philippe Pierre, Rafael J. Argüello, Lionel Spinelli, Magali Irla
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Regulatory T cells (Treg) are critical players of immune tolerance that develop in the thymus via two distinct developmental pathways involving CD25+Foxp3− and CD25−Foxp3lo precursors. However, the mechanisms regulating the recently iden
Externí odkaz:
https://doaj.org/article/45d2e9da70904a42bd5946d002075ce9
Autor:
Jérémy C. Santamaria, Sylvia Vuillier, Ariel O. Galindo-Albarrán, Sarah Castan, Claire Detraves, Olivier P. Joffre, Paola Romagnoli, Joost P. M. van Meerwijk
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Regulatory T lymphocytes expressing the transcription factor Foxp3 (Tregs) play an important role in the prevention of autoimmune diseases and other immunopathologies. Aberrations in Treg-mediated immunosuppression are therefore thought to be involve
Externí odkaz:
https://doaj.org/article/4d76320316e444f081f86a653726f9bd
Autor:
Cécile Apert, Ariel O. Galindo-Albarrán, Sarah Castan, Claire Detraves, Héloise Michaud, Nicola McJannett, Bart Haegeman, Simon Fillatreau, Bernard Malissen, Georg Holländer, Saulius Žuklys, Jérémy C. Santamaria, Olivier P. Joffre, Paola Romagnoli, Joost P. M. van Meerwijk
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Development of Foxp3-expressing regulatory T-lymphocytes (Treg) in the thymus is controlled by signals delivered in T-cell precursors via the TCR, co-stimulatory receptors, and cytokine receptors. In absence of IL-2, IL-15 or their receptors, fewer T
Externí odkaz:
https://doaj.org/article/99c45be99e5148a1b68f7c4d8d930a42
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Foxp3+ regulatory T cells (Treg) maintain the integrity of the organism by preventing excessive immune responses. These cells protect against autoimmune diseases but are also important regulators of other immune responses including inflammation, alle
Externí odkaz:
https://doaj.org/article/88017c15223641cf8c9374d3ec192a68
Autor:
Jonathan Charaix, Alexia Borelli, Jérémy C. Santamaria, Lionel Chasson, Matthieu Giraud, Arnauld Sergé, Magali Irla
Publikováno v:
Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, 2022, 79 (7), pp.355. ⟨10.1007/s00018-022-04328-9⟩
Cellular and Molecular Life Sciences, 2022, 79 (7), pp.355. ⟨10.1007/s00018-022-04328-9⟩
International audience; Thymically-derived Foxp3+ regulatory T cells (Treg) critically control immunological tolerance. These cells are generated in the medulla through high affinity interactions with medullary thymic epithelial cells (mTEC) expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde0ee3ae663b60df749ea0658e03593
https://hal-amu.archives-ouvertes.fr/hal-03754435
https://hal-amu.archives-ouvertes.fr/hal-03754435
Autor:
Olivier Joffre, Bart Haegeman, Jérémy C. Santamaria, Joost P. M. van Meerwijk, Sarah Castan, Paola Romagnoli, Ariel Galindo-Albarrán
Publikováno v:
Diabetes
Diabetes, American Diabetes Association, 2021, 70 (8), pp.1729-1737. ⟨10.2337/db20-1072⟩
Diabetes, 2021, 70 (8), pp.1729-1737. ⟨10.2337/db20-1072⟩
Diabetes, American Diabetes Association, 2021, 70 (8), pp.1729-1737. ⟨10.2337/db20-1072⟩
Diabetes, 2021, 70 (8), pp.1729-1737. ⟨10.2337/db20-1072⟩
Regulatory T lymphocytes expressing the forkhead/winged helix transcription factor Foxp3 (Treg) play a vital role in the protection of the organism from autoimmune disease and other immunopathologies. The antigen specificity of Treg plays an importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc033f43c579b397a74202c99b665de8
https://doi.org/10.2337/db20-1072
https://doi.org/10.2337/db20-1072
Autor:
Noella Lopes, Nicolas Boucherit, Jérémy C Santamaria, Nathan Provin, Jonathan Charaix, Pierre Ferrier, Matthieu Giraud, Magali Irla
Publikováno v:
eLife
eLife, 2022, 11, ⟨10.7554/eLife.69982⟩
eLife, 2022, 11, ⟨10.7554/eLife.69982⟩
Interactions of developing T cells with Aire+ medullary thymic epithelial cells expressing high levels of MHCII molecules (mTEChi) are critical for the induction of central tolerance in the thymus. In turn, thymocytes regulate the cellularity of Aire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82952f4cf0fef28368b00d606c96df48
https://hal-amu.archives-ouvertes.fr/hal-03754405
https://hal-amu.archives-ouvertes.fr/hal-03754405
Autor:
Jonathan, Charaix, Alexia, Borelli, Jérémy C, Santamaria, Lionel, Chasson, Matthieu, Giraud, Arnauld, Sergé, Magali, Irla
Publikováno v:
Cellular and molecular life sciences : CMLS. 79(7)
Thymically-derived Foxp3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::434ef270b522e23a7ca936fae137a452
https://pubmed.ncbi.nlm.nih.gov/35678896
https://pubmed.ncbi.nlm.nih.gov/35678896
Autor:
Joost P.M. van Meerwijk, Paola Romagnoli, Bart Haegeman, Olivier P. Joffre, Jérémy C. Santamaria, Sarah Castan, Ariel Galindo-Albarrán
Regulatory T lymphocytes expressing the forkhead/winged helix transcription factor Foxp3 (Treg) play a vital role in the protection of the organism from autoimmune disease and other immunopathologies. The antigen-specificity of Treg plays an importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c936a173bcb42bd774e501c150e1188
https://doi.org/10.2337/figshare.14611911.v1
https://doi.org/10.2337/figshare.14611911.v1