Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Jérémie Piton"'
Autor:
Lindsey de Vos, Joseph Daniels, Avuyonke Gebengu, Laura Mazzola, Birgitta Gleeson, Benjamin Blümel, Jérémie Piton, Mandisa Mdingi, Ranjana M.S. Gigi, Cecilia Ferreyra, Jeffrey D. Klausner, Remco P.H. Peters
Publikováno v:
BMC Health Services Research, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background South Africa maintains an integrated health system where syndromic management of sexually transmitted infections (STI) is the standard of care. An estimated 2 million cases of Neisseria gonorrhoeae (N. gonorrhoeae) occur in South
Externí odkaz:
https://doaj.org/article/9bc67c67727f4c70ab089b380805ab4c
Autor:
Lindsey de Vos, Joseph Daniels, Avuyonke Gebengu, Laura Mazzola, Birgitta Gleeson, Jérémie Piton, Mandisa Mdingi, Ranjana Gigi, Cecilia Ferreyra, Jeffrey D Klausner, Remco P H Peters
Publikováno v:
PLoS ONE, Vol 18, Iss 6, p e0286666 (2023)
Accurate and user-friendly rapid point-of-care diagnostic tests (POCT) are needed to optimize treatment of Neisseria gonorrhoeae, especially in low-resource settings where syndromic management is the standard of care for sexually transmitted infectio
Externí odkaz:
https://doaj.org/article/8be76be75e16413c9595bd45adbb78e7
Publikováno v:
Journal of Structural Biology: X, Vol 4, Iss , Pp 100029- (2020)
The EspB protein of Mycobacterium tuberculosis is a 60 kDa virulence factor, implicated in conjugation and exported by the ESX-1 system of which it may also be a component. Previous attempts to obtain high-resolution maps of EspB by cryo-electron mic
Externí odkaz:
https://doaj.org/article/37fcbf9687124c9d9621d401e0e59da9
Autor:
Andréanne Lupien, Caroline Shi-Yan Foo, Svetlana Savina, Anthony Vocat, Jérémie Piton, Natalia Monakhova, Andrej Benjak, Dirk A Lamprecht, Adrie J C Steyn, Kevin Pethe, Vadim A Makarov, Stewart T Cole
Publikováno v:
PLoS Pathogens, Vol 16, Iss 1, p e1008270 (2020)
The emergence of multi-drug (MDR-TB) and extensively-drug resistant tuberculosis (XDR-TB) is a major threat to the global management of tuberculosis (TB) worldwide. New chemical entities are of need to treat drug-resistant TB. In this study, the mode
Externí odkaz:
https://doaj.org/article/b7f8b7461a4442bc8a002d6f37ec16b1
Publikováno v:
Cell Reports, Vol 27, Iss 3, Pp 886-899.e6 (2019)
Summary: In ectotherms, increased ambient temperature requires the organism to consume substantial amounts of energy to sustain a higher metabolic rate, prevent cellular damage, and respond to heat stress. Here, we identify a heat-inducible apolipopr
Externí odkaz:
https://doaj.org/article/cbc241f96e4c4976995d6387e68b9ae6
Autor:
Caroline S. Foo, Andréanne Lupien, Maryline Kienle, Anthony Vocat, Andrej Benjak, Raphael Sommer, Dirk A. Lamprecht, Adrie J. C. Steyn, Kevin Pethe, Jérémie Piton, Karl-Heinz Altmann, Stewart T. Cole
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT New drugs are needed to control the current tuberculosis (TB) pandemic caused by infection with Mycobacterium tuberculosis. We report here on our work with AX-35, an arylvinylpiperazine amide, and four related analogs, which are potent antit
Externí odkaz:
https://doaj.org/article/adb9ac67e2c14c6b855d0f2b8719a48c
Autor:
Mariane M A Stefani, Charlotte Avanzi, Samira Bührer-Sékula, Andrej Benjak, Chloé Loiseau, Pushpendra Singh, Maria A A Pontes, Heitor S Gonçalves, Emerith M Hungria, Philippe Busso, Jérémie Piton, Maria I S Silveira, Rossilene Cruz, Antônio Schetinni, Maurício B Costa, Marcos C L Virmond, Suzana M Diorio, Ida M F Dias-Baptista, Patricia S Rosa, Masanori Matsuoka, Maria L F Penna, Stewart T Cole, Gerson O Penna
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 6, p e0005598 (2017)
Since leprosy is both treated and controlled by multidrug therapy (MDT) it is important to monitor recurrent cases for drug resistance and to distinguish between relapse and reinfection as a means of assessing therapeutic efficacy. All three objectiv
Externí odkaz:
https://doaj.org/article/91540a58ac934e209d0d7e74859d55f7
Autor:
Jérémie Piton, Stéphanie Petrella, Marc Delarue, Gwénaëlle André-Leroux, Vincent Jarlier, Alexandra Aubry, Claudine Mayer
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12245 (2010)
Mycobacterium tuberculosis DNA gyrase, an indispensable nanomachine involved in the regulation of DNA topology, is the only type II topoisomerase present in this organism and is hence the sole target for quinolone action, a crucial drug active agains
Externí odkaz:
https://doaj.org/article/145db31de7de409e956831f775903fb4
Autor:
Stewart T. Cole, Jérémie Piton, João Neres, John D. McKinney, Raju Mukherjee, Raphael Sommer, Wilbert Bitter, Vadim Makarov, Astrid M. van der Sar, Neeraj Dhar, Paul J. Dyson, Thierry Laroche
Publikováno v:
Sommer, R, Neres, J, Piton, J, Dhar, N, van der Sar, A, Mukherjee, R, Laroche, T, Dyson, P J, McKinney, J D, Bitter, W, Makarov, V & Cole, S T 2018, ' Fluorescent Benzothiazinone Analogues Efficiently and Selectively Label Dpre1 in Mycobacteria and Actinobacteria ', Acs chemical biology, vol. 13, no. 11, pp. 3184-3192 . https://doi.org/10.1021/acschembio.8b00790
Acs chemical biology, 13(11), 3184-3192. American Chemical Society
ACS chemical biology, 13(11), 3184-3192. American Chemical Society
Sommer, R, Neres, J, Piton, J, Dhar, N, van der Sar, A, Mukherjee, R, Laroche, T, Dyson, P J, McKinney, J D, Bitter, W, Makarov, V & Cole, S T 2018, ' Fluorescent Benzothiazinone Analogues Efficiently and Selectively Label Dpre1 in Mycobacteria and Actinobacteria ', ACS chemical biology, vol. 13, no. 11, pp. 3184-3192 . https://doi.org/10.1021/acschembio.8b00790
Acs chemical biology, 13(11), 3184-3192. American Chemical Society
ACS chemical biology, 13(11), 3184-3192. American Chemical Society
Sommer, R, Neres, J, Piton, J, Dhar, N, van der Sar, A, Mukherjee, R, Laroche, T, Dyson, P J, McKinney, J D, Bitter, W, Makarov, V & Cole, S T 2018, ' Fluorescent Benzothiazinone Analogues Efficiently and Selectively Label Dpre1 in Mycobacteria and Actinobacteria ', ACS chemical biology, vol. 13, no. 11, pp. 3184-3192 . https://doi.org/10.1021/acschembio.8b00790
Benzothiazinones (BTZ) are highly potent bactericidal inhibitors of mycobacteria and the lead compound, BTZ043, and the optimized drug candidate, PBTZ169, have potential for the treatment of tuberculosis. Here, we exploited the tractability of the BT
Autor:
Rita, Székely, Monica, Rengifo-Gonzalez, Vinayak, Singh, Olga, Riabova, Andrej, Benjak, Jérémie, Piton, Mena, Cimino, Etienne, Kornobis, Valerie, Mizrahi, Kai, Johnsson, Giulia, Manina, Vadim, Makarov, Stewart T, Cole
Publikováno v:
ACS infectious diseases. 6(11)
Screening of a diversity-oriented compound library led to the identification of two 6,11-dioxobenzo[