Zobrazeno 1 - 10
of 128
pro vyhledávání: '"János Szöllosi"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The actual interaction between signaling species in cellular processes is often more important than their expression levels. Förster resonance energy transfer (FRET) is a popular tool for studying molecular interactions, since it is highly
Externí odkaz:
https://doaj.org/article/01884f0f40104be2a06fe74f594bcc64
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The epidermal growth factor (EGF) receptor (EGFR) undergoes ligand-dependent dimerization to initiate transmembrane signaling. Although crystallographic structures of the extracellular and kinase domains are available, ligand binding has not been qua
Externí odkaz:
https://doaj.org/article/50cbf683dd2d43549e648ebc418211c7
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)
Abstract Background Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate that carries a cytotoxic drug (DM1) to HER2-positive cancer. The target of T-DM1 (HER2) is present also on cancer-derived exosomes. We hypothesized that exosome-bound T-D
Externí odkaz:
https://doaj.org/article/5e7c9937327e48098ffdd421d894b730
Publikováno v:
Molecules, Vol 20, Iss 12, Pp 22578-22620 (2015)
The review will discuss in detail the effects of polyphenols on breast cancer, including both the advantages and disadvantages of the applications of these natural compounds. First, we focus on the characterization of the main classes of polyphenols
Externí odkaz:
https://doaj.org/article/b5e17f1c75cc44a0810a4bfea8c6556e
Autor:
Anna Király, Tímea Váradi, Tímea Hajdu, Ralph Rühl, Carlos M. Galmarini, János Szöllősi, Peter Nagy
Publikováno v:
Marine Drugs, Vol 11, Iss 12, Pp 4858-4875 (2013)
The mechanism of action of elisidepsin (PM02734, Irvalec®) is assumed to involve membrane permeabilization via attacking lipid rafts and hydroxylated lipids. Here we investigate the role of hypoxia in the mechanism of action of elisidepsin. Culturin
Externí odkaz:
https://doaj.org/article/f51e71c5d41e46428207b192790bf399
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)
BMC Cancer
BMC Cancer
Background Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate that carries a cytotoxic drug (DM1) to HER2-positive cancer. The target of T-DM1 (HER2) is present also on cancer-derived exosomes. We hypothesized that exosome-bound T-DM1 may co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2effd9ca84ce03e637d78d9c9bc949
https://doi.org/10.1186/s12885-018-4418-2
https://doi.org/10.1186/s12885-018-4418-2
Autor:
János Szöllosi, Tímea Váradi, Péter Nagy, José Manuel Molina-Guijarro, Janos Roszik, György Vereb, Carlos M. Galmarini, Duarte Lisboa
Publikováno v:
European Journal of Pharmacology. 667:91-99
Elisidepsin is a marine-derived anti-tumor agent with unique mechanism of action. It has been suggested to induce necrosis associated with severe membrane damage. Since indirect evidence points to the involvement of ErbB receptor tyrosine kinases and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14fab356178aad91b4214a320dcf918a
https://doi.org/10.1016/j.ejphar.2011.05.064
https://doi.org/10.1016/j.ejphar.2011.05.064
Publikováno v:
Journal of Endometriosis. 3:93-98
Purpose Laparoscopy is considered the gold standard for the diagnosis and treatment of endometriosis. Controlled ovarian hyperstimulation-intrauterine insemination (COH-IUI) is often used to treat women with infertility associated with endometriosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::052dcb20697be68e983cf75b01e579f8
https://doi.org/10.5301/je.2011.8529
https://doi.org/10.5301/je.2011.8529
Autor:
Yakir Guri, Janos Roszik, Zsuzsanna Pályi-Krekk, Péter Nagy, Reno Debets, Zsolt Sebestyén, Arpad Szoor, Coen Govers, János Szöllosi, György Vereb
Publikováno v:
European Journal of Immunology, 41(5), 1288-1297. Wiley-VCH
T-cell receptors (TCRs) can be genetically modified to improve gene-engineered T-cell responses, a strategy considered critical for the success of clinical TCR gene therapy to treat cancers. TCR:zeta, which is a heterodimer of TCR alpha and beta chai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a44074d077e6855f78cf05b12a4188
https://doi.org/10.1002/eji.200940233
https://doi.org/10.1002/eji.200940233
Autor:
János Szöllosi, Hideyuki Saya, Zsuzsanna Pályi-Krekk, Tamás Kovács, Péter Nagy, Osamu Nagano, Márk Barok
Publikováno v:
Cancer Letters. 263:231-242
Activation of the ErbB family of receptor tyrosine kinases is involved in a range of human cancers. Transmembrane signaling mediated by ErbB proteins is stimulated by peptide growth factors and is blocked by monoclonal antibodies such as trastuzumab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e3321f0ca57dc0be0883154ba5a1fd
https://doi.org/10.1016/j.canlet.2008.01.014
https://doi.org/10.1016/j.canlet.2008.01.014