Zobrazeno 1 - 10
of 154
pro vyhledávání: '"JÓZSEF, TÓVÁRI"'
Autor:
Sára Eszter Surguta, Marcell Baranyi, Laura Svajda, Mihály Cserepes, Ivan Ranđelović, Enikő Tátrai, Balázs Hegedűs, József Tóvári
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Lung cancer is the leading cause of cancer-related death globally. Metastasis is the most common reason of mortality in which hypoxia is suggested to have a pivotal role. However, the effect of hypoxia on the metastatic potential and migrato
Externí odkaz:
https://doaj.org/article/cb277a475cdd4d908f18552eefd4c861
Autor:
Eszter Molnár, Marcell Baranyi, Krisztina Szigeti, Luca Hegedűs, Fanni Bordás, Zsófia Gábriel, Gréta Petényi, József Tóvári, Balázs Hegedűs, József Tímár
Publikováno v:
Pathology and Oncology Research, Vol 30 (2024)
Pancreatic adenocarcinoma is one of the deadliest forms of cancer with no effective therapeutic options. A KRAS mutation can be found in up to 90% of all pancreatic tumors, making it a promising therapeutic target. The introduction of new KRAS inhibi
Externí odkaz:
https://doaj.org/article/218556c3ae364339970c587752baa280
Autor:
Péter Ábrányi-Balogh, Dávid Bajusz, Zoltán Orgován, Aaron B. Keeley, László Petri, Nikolett Péczka, Tibor Viktor Szalai, Gyula Pálfy, Márton Gadanecz, Emma K. Grant, Tímea Imre, Tamás Takács, Ivan Ranđelović, Marcell Baranyi, András Marton, Gitta Schlosser, Qirat F. Ashraf, Elvin D. de Araujo, Tamás Karancsi, László Buday, József Tóvári, András Perczel, Jacob T. Bush, György M. Keserű
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Fragment screening is a popular strategy of generating viable chemical starting points especially for challenging targets. Although fragments provide a better coverage of chemical space and they have typically higher chance of binding, their
Externí odkaz:
https://doaj.org/article/0a79f05dcd144d4ba343eaa1f806db99
Autor:
Gergely Attila Rácz, Nikolett Nagy, György Várady, József Tóvári, Ágota Apáti, Beáta G. Vértessy
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract In human cells two dUTPase isoforms have been described: one nuclear (DUT-N) and one mitochondrial (DUT-M), with cognate localization signals. In contrast, here we identified two additional isoforms; DUT-3 without any localization signal and
Externí odkaz:
https://doaj.org/article/3c62db1bbec842f69dc1d409652a918e
Autor:
Nikolett Gémes, József Á. Balog, Patrícia Neuperger, Erzsébet Schlegl, Imre Barta, János Fillinger, Balázs Antus, Ágnes Zvara, Zoltán Hegedűs, Zsolt Czimmerer, Máté Manczinger, Gergő Mihály Balogh, József Tóvári, László G. Puskás, Gábor J. Szebeni
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionTobacco smoking generates airway inflammation in chronic obstructive pulmonary disease (COPD), and its involvement in the development of lung cancer is still among the leading causes of early death. Therefore, we aimed to have a better un
Externí odkaz:
https://doaj.org/article/59d1e13b34fc423cb0f8e6ed54c43031
Autor:
Balázs Vári, Levente Dókus, Adina Borbély, Anikó Gaál, Diána Vári-Mező, Ivan Ranđelović, Anna Sólyom-Tisza, Zoltán Varga, Norbert Szoboszlai, Gábor Mező, József Tóvári
Publikováno v:
Drug Delivery, Vol 30, Iss 1 (2023)
AbstractChemotherapy is still a leading therapeutic approach in various tumor types that is often accompanied by a poor prognosis because of metastases. PEGylated liposomes with CREKA targeting moiety are well-known therapeutic agents, especially in
Externí odkaz:
https://doaj.org/article/20072f91186a426695d8bc4c72c657cf
Autor:
Marco Zambra, Ivan Ranđelović, Francesco Talarico, Adina Borbély, Laura Svajda, József Tóvári, Gábor Mező, Lizeth Bodero, Sveva Colombo, Federico Arrigoni, Elettra Fasola, Silvia Gazzola, Umberto Piarulli
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Antibody-Drug Conjugates (ADCs) and Small Molecule-Drug Conjugates (SMDCs) represent successful examples of targeted drug-delivery technologies for overcoming unwanted side effects of conventional chemotherapy in cancer treatment. In both strategies,
Externí odkaz:
https://doaj.org/article/8398d4cb126548328281d797762b4133
Autor:
Ágnes Czikora, Katalin Erdélyi, Tamás Ditrói, Noémi Szántó, Eszter Petra Jurányi, Szilárd Szanyi, József Tóvári, Tamás Strausz, Péter Nagy
Publikováno v:
Redox Biology, Vol 57, Iss , Pp 102505- (2022)
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest of all cancer types with a constant rise in global incidence. Therefore, better understanding of PDAC biology, in order to design more efficient diagnostic and treatment modalities, is a
Externí odkaz:
https://doaj.org/article/d9d85c4dbdf8409da237f8761361bc04
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Reverse transcription—quantitative real-time PCR (RT-qPCR) is a ubiquitously used method in biological research, however, finding appropriate reference genes for normalization is challenging. We aimed to identify genes characterized with l
Externí odkaz:
https://doaj.org/article/75fd21e5bc2547d4bfcc35d5f61d861c
Autor:
József Tóvári, Diána Vári-Mező, Sára Eszter Surguta, Andrea Ladányi, Attila Kigyós, Mihály Cserepes
Publikováno v:
Cells, Vol 12, Iss 14, p 1919 (2023)
Malignant melanoma is challenging to treat, and metastatic cases need chemotherapy strategies. Targeted inhibition of commonly mutant BRAF V600E by inhibitors is efficient but eventually leads to resistance and progression in the vast majority of cas
Externí odkaz:
https://doaj.org/article/e911b8ddcc184cc9bbfd3b98497b7a51