Výsledky vyhledávání - "J, deKernion"

Androgen deprivation induces selective outgrowth of aggressive hormone-refractory prostate cancer clones expressing distinct cellular and molecular properties not present in parental androgen-dependent cancer cells

Autor: C L, Tso, W H, McBride, J, Sun, B, Patel, K H, Tsui, S H, Paik, B, Gitlitz, R, Caliliw, A, van Ophoven, L, Wu, J, deKernion, A, Belldegrun

Publikováno v: Cancer journal (Sudbury, Mass.). 6(4)

The mechanism of progression of human prostate cancer (CaP) cells under androgen ablation therapy remains unclear. To study the alternative pathways of CaP cell growth under conditions of androgen deprivation, androgen-independent CaP variants were s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::534c122d879be986bd8c768d2738d0ab
https://pubmed.ncbi.nlm.nih.gov/11038139

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Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step process

Autor: N, Craft, C, Chhor, C, Tran, A, Belldegrun, J, DeKernion, O N, Witte, J, Said, R E, Reiter, C L, Sawyers

Publikováno v: Cancer research. 59(19)

Prostate cancers require androgen for growth but progress to an androgen-independent stage under the selective pressure of androgen ablation therapy. Here we describe a novel human prostate cancer xenograft (LAPC-9) propagated by serial passage in ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7a50274716e8f71d03f0f788295fb317
https://pubmed.ncbi.nlm.nih.gov/10519419

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Presentation of renal tumor antigens by human dendritic cells activates tumor-infiltrating lymphocytes against autologous tumor: implications for live kidney cancer vaccines

Autor: P, Mulders, C L, Tso, B, Gitlitz, R, Kaboo, A, Hinkel, S, Frand, S, Kiertscher, M D, Roth, J, deKernion, R, Figlin, A, Belldegrun

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5(2)

The clinical impact of dendritic cells (DCs) in the treatment of human cancer depends on their unique role as the most potent antigen-presenting cells that are capable of priming an antitumor T-cell response. Here, we demonstrate that functional DCs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e810a75191a227e7972f8d05869d10c3
https://pubmed.ncbi.nlm.nih.gov/10037196

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Treatment with finasteride following radical prostatectomy for prostate cancer

Autor: D. Crawford, Glenn J. Gormley, D. Ferguson, Jennifer Ng, F. Schroeder, J. Rajfer, Y. Fradet, Richard G. Middleton, J. Smith, R. Boake, J. Dekernion, M. Lieber, M. Soloway, E. Ramsey, G. Andriole, J. Trachtenberg, D. Kadmon, N. Block, J. Perreault

Publikováno v: Urology. 45(3)

Objectives The objective of this study was to evaluate the effect of finasteride (10 mg/d) or placebo on serum prostate-specific antigen (PSA) and recurrence rates in men with detectable PSA levels after radical prostatectomy. Methods A total of 120

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84201c9bd94ca3ecefa42de29fe50e25
https://pubmed.ncbi.nlm.nih.gov/7533461

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Immunotherapy for renal cell carcinoma

Autor: A, Belldegrun, R, Figlin, J, Danella, J, deKernion

Publikováno v: Seminars in urology. 10(1)

The prognosis for patients with metastatic renal cell carcinoma may be brightening. Immunotherapy may offer an effective alternative approach for this disease. Continuing advances in immunology and molecular biology will probably reinforce the early

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d4e6a2e3d798bf6d26bee6fc44faafab
https://pubmed.ncbi.nlm.nih.gov/1565900

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A comparison of hydroxyurea, methyl-chloroethyl-cyclohexy-nitrosourea and cyclophosphamide in patients with advanced carcinoma of the prostate

Autor: J.E. Pontes, George R. Prout, Nelson H. Slack, Stefan A. Loening, J.F. Gaeta, T. M. Chu, J. Dekernion, Mark S. Soloway, Joseph D. Schmidt, R.P. Gibbons, Douglas E. Johnson, W.W. Scott, Gerald P. Murphy

Publikováno v: The Journal of urology. 125(6)

This is the fifth completed randomized clinical trial of the National Prostatic Cancer Project. There were 125 patients with histologically confirmed relapsing clinical stage D prostatic cancer randomized to receive hydroxyurea, methyl-chloroethyl-cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89508b9e3a2b220fc9057d1000e0c97b
https://pubmed.ncbi.nlm.nih.gov/7017170

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Intravesical bacillus Calmette-Guérin and second primary malignancies

Autor: S. Brosman, C. Richardson, Patrick Guinan, D. Reitsma, M. Hanna, R. Williams, J. Dekernion, Donald L. Lamm

Publikováno v: Urology. 33(5)

In an effort to answer the question, “Does intravesical bacillus Calmette-Guerin (BCG) therapy increase the incidence of second primary malignancies,” the records of 153 patients treated with BCG for carcinoma in situ of the urinary bladder were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67025230a06e3f150aaa1f6fc7b449a
https://pubmed.ncbi.nlm.nih.gov/2711556

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