Zobrazeno 1 - 10
of 60
pro vyhledávání: '"J, Yergey"'
Autor:
Brian P. Kennedy, Philip Tagari, Diane Ethier, Donna A. Francis, Stacia Kargman, J. Yergey, Denis Riendeau, Jean-Pierre Falgueyret, Elizabeth Wong, Wanda Cromlish, Gillian Greig, Gary P. O'Neill, Jilly F. Evans
Publikováno v:
Biochemical Pharmacology. 52:1113-1125
Selective inhibitors of prostaglandin synthase-2 (PGHS-2) possess potent anti-inflammatory, antipyretic, and analgesic properties but demonstrate reduced side-effects (e.g. gastrotoxicity) when compared with nonselective inhibitors of PGHS-1 and -2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8035c8761e9569d3d2ddaf3c7dd70b8
https://doi.org/10.1016/0006-2952(96)00462-5
https://doi.org/10.1016/0006-2952(96)00462-5
Autor:
Robert Zamboni, Deborah A. Nicoll-Griffith, Thomas R. Jones, P. Masson, M. Belley, H. Piechuta, J. Yergey, Robert N. Young, Kathleen M. Metters, A. Lord, R. Gordon, C. Rochette, Karst Hoogsteen, Y. B. Xiang, M. McAuliffe, Anthony W. Ford-Hutchinson, Nicole Sawyer, C. S. Mcfarlane, Marc Labelle, E. Champion, Nathalie Ouimet, Yves Leblanc, C.B. Pickett
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:463-468
The styryl quinoline thioether 5 (L-699,392) is a potent and orally active leukotriene D4 antagonist. The structure-activity studies leading to its discovery are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a7d926352711059f67e0cefce5df91c
https://doi.org/10.1016/0960-894x(94)80017-0
https://doi.org/10.1016/0960-894x(94)80017-0
Autor:
Robert Zamboni, E. Champion, Karst Hoogsteen, Y. B. Xiang, M. Belley, M. McAuliffe, Nathalie Ouimet, R. Gordon, Kathleen M. Metters, Marc Labelle, P. Masson, C. Rochette, H. Piechuta, Anthony W. Ford-Hutchinson, A. Lord, C. S. Mcfarlane, Nicole Sawyer, Deborah A. Nicoll-Griffith, Yves Leblanc, C.B. Pickett, Thomas R. Jones, J. Yergey
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7800b682b0553402eaf50b9591cfd62
https://doi.org/10.1002/chin.199431162
https://doi.org/10.1002/chin.199431162
Autor:
G Y, Ng, S, Bertrand, R, Sullivan, N, Ethier, J, Wang, J, Yergey, M, Belley, L, Trimble, K, Bateman, L, Alder, A, Smith, R, McKernan, K, Metters, G P, O'Neill, J C, Lacaille, T E, Hébert
Publikováno v:
Molecular pharmacology. 59(1)
Gamma-aminobutyric acid (GABA) activates two qualitatively different inhibitory mechanisms through ionotropic GABA(A) multisubunit chloride channel receptors and metabotropic GABA(B) G protein-coupled receptors. Evidence suggests that pharmacological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::39acdf387f79553b1e8479d24874c875
https://pubmed.ncbi.nlm.nih.gov/11125035
https://pubmed.ncbi.nlm.nih.gov/11125035
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461374305
Leukotriene A4 (LTA4) is a product of the 5-lipoxygenase reaction and a key intermediate in the biosynthesis of leukotrienes. LTA4 serves as a substrate for the enzymatic hydrolysis to leukotriene B4 or conjugation with glutathione to yield the pepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae6263c90dc530cc5f4cb20257cef45c
https://doi.org/10.1007/978-1-4615-5325-0_10
https://doi.org/10.1007/978-1-4615-5325-0_10
Autor:
N, Chauret, D, Nicoll-Griffith, R, Friesen, C, Li, L, Trimble, D, Dubé, R, Fortin, Y, Girard, J, Yergey
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 23(12)
Hepatic microsomes from different species were used to study the oxidative metabolism of L-746,530 and L-739,010, two potent and specific 5-lipoxygenase inhibitors. HPLC analysis of the incubates obtained from the microsomal incubations of L-739,010
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::58133021e4fe4b3f24f8a39c9a1df652
https://pubmed.ncbi.nlm.nih.gov/8689939
https://pubmed.ncbi.nlm.nih.gov/8689939
Autor:
G P, O'Neill, B P, Kennedy, J A, Mancini, S, Kargman, M, Ouellet, J, Yergey, J P, Falgueyret, W A, Cromlish, P, Payette, C C, Chan
Publikováno v:
Agents and actions. Supplements. 46
The main target of non-steroidal anti-inflammatory drugs (NSAIDs) is prostaglandin G/H synthase (PGHS), also known as cyclooxygenase (COX), which exists as two isoforms. In order to evaluate the contributions of PGHS isoforms to physiological and pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::96474a9742668b76ef4597606088e2a1
https://pubmed.ncbi.nlm.nih.gov/7610986
https://pubmed.ncbi.nlm.nih.gov/7610986
Autor:
G. P. O’neill, B. P. Kennedy, J. A. Mancini, S. Kargman, M. Ouellet, J. Yergey, J.-P. Falgueyret, W. A. Cromlish, P. Payette, C.-C. Chan, S. A. Culp, C. Vincent, C. Boily, M. Abramovitz, J. F. Evans, A. W. Ford-Hutchinson, P. J. Vickers, M. D. Percival
Publikováno v:
Novel Molecular Approaches to Anti-Inflammatory Therapy ISBN: 9783034872782
The main target of non-steroidal anti-inflammatory drugs (NSAIDs) is prostaglandin G/H synthase (PGHS), also known as cyclooxygenase (COX), which exists as two isoforms. In order to evaluate the contributions of PGHS isoforms to physiological and pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08a561faab377b4e0222a8bf132d0d0b
https://doi.org/10.1007/978-3-0348-7276-8_16
https://doi.org/10.1007/978-3-0348-7276-8_16
Publikováno v:
Archives of biochemistry and biophysics. 315(1)
Recombinant human cyclooxygenase-2 (hCox-2, Prostaglandin G/H synthase-2) has been purified from baculovirus-Sf9 and vaccina virus-Cos-7 cell expression systems. The detergent-solubilized, purified enzyme is heterogeneous in terms of its glycosylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b8e659d64d80ac357cf125429ceaf0
https://pubmed.ncbi.nlm.nih.gov/7979387
https://pubmed.ncbi.nlm.nih.gov/7979387
Autor:
Susana Liu, Helene Perrier, Denis Riendeau, J. Yergey, Sylvie Desmarais, Philip K. Weech, Chun-Sing Li, Jocelyne Guay, F. Laliberte, Deborah A. Nicoll-Griffith
Publikováno v:
The Journal of biological chemistry. 269(22)
Arachidonyl trifluoromethyl ketone (AACOCF3) is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2) (Street, I. P., Lin, H.-K., Laliberte, F., Ghomashchi, F., Wang, Z., Perrier, H., Tremblay, N. M., Huang, Z
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e7fe514609a2fe6dbf966a4381edcf
https://pubmed.ncbi.nlm.nih.gov/8195210
https://pubmed.ncbi.nlm.nih.gov/8195210