Zobrazeno 1 - 10
of 414
pro vyhledávání: '"J, Worrall"'
Autor:
Helena E. Sverak, Luke N. Yaeger, Liam J. Worrall, Condurache M. Vacariu, Amy J. Glenwright, Marija Vuckovic, Zayni-Dean Al Azawi, Ryan P. Lamers, Victoria A. Marko, Clarissa Skorupski, Arvind S. Soni, Martin E. Tanner, Lori L. Burrows, Natalie CJ Strynadka
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Bacteria invest significant resources into the continuous creation and tailoring of their essential protective peptidoglycan (PG) cell wall. Several soluble PG biosynthesis products in the periplasm are transported to the cytosol for recycli
Externí odkaz:
https://doaj.org/article/1807814824a146fe833402f271005378
Autor:
Benjamin J Worrall, Alexander Papachristos, Ahmad Aniss, Anthony Glover, Stan B Sidhu, Roderick J Clifton-Bligh, Diana Learoyd, Venessa H M Tsang, Matti Gild, Bruce G Robinson, Mark S Sywak
Publikováno v:
Endocrine Oncology, Vol 3, Iss 1, Pp 1-8 (2023)
Background: The 2015 American Thyroid Association (ATA) Guidelines permit thyroid lobectomy (TL) or total thyroidectomy in the management of low-risk papillary thyroid cancer (PTC). As definitive risk-stratification is only possible post-operatively,
Externí odkaz:
https://doaj.org/article/e0ba1150d0774a238a6b230c9141ca61
Autor:
Marcos Allende, Diego López León, Sergio Cerón, Adrián Pareja, Erick Pacheco, Antonio Leal, Marcelo Da Silva, Alejandro Pardo, Duncan Jones, David J. Worrall, Ben Merriman, Jonathan Gilmore, Nick Kitchener, Salvador E. Venegas-Andraca
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-23 (2023)
Abstract The advent of quantum computing threatens blockchain protocols and networks because they utilize non-quantum resistant cryptographic algorithms. When quantum computers become robust enough to run Shor’s algorithm on a large scale, the most
Externí odkaz:
https://doaj.org/article/d31029a4722f4f7fb374903705fd70e9
Autor:
Jimena Pérez-Vargas, Liam J. Worrall, Andrea D. Olmstead, Anh-Tien Ton, Jaeyong Lee, Ivan Villanueva, Connor A. H. Thompson, Svenja Dudek, Siobhan Ennis, Jason R. Smith, Tirosh Shapira, Joshua De Guzman, Shutong Gang, Fuqiang Ban, Marija Vuckovic, Michael Bielecki, Suzana Kovacic, Calem Kenward, Christopher Yee Hong, Danielle G. Gordon, Paul N. Levett, Mel Krajden, Richard Leduc, Pierre-Luc Boudreault, Masahiro Niikura, Mark Paetzel, Robert N. Young, Artem Cherkasov, Natalie C. J. Strynadka, François Jean
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
Antivirals with broad coronavirus activity are important for treating high-risk individuals exposed to the constantly evolving SARS-CoV-2 variants of concern (VOCs) as well as emerging drug-resistant variants. We developed and characterized a novel c
Externí odkaz:
https://doaj.org/article/af2615cbac4f4e1583d54bc3e7ff1625
Autor:
Nina E. Weisser, Mario Sanches, Eric Escobar-Cabrera, Jason O’Toole, Elizabeth Whalen, Peter W. Y. Chan, Grant Wickman, Libin Abraham, Kate Choi, Bryant Harbourne, Antonios Samiotakis, Andrea Hernández Rojas, Gesa Volkers, Jodi Wong, Claire E. Atkinson, Jason Baardsnes, Liam J. Worrall, Duncan Browman, Emma E. Smith, Priya Baichoo, Chi Wing Cheng, Joy Guedia, Sohyeong Kang, Abhishek Mukhopadhyay, Lisa Newhook, Anders Ohrn, Prajwal Raghunatha, Matteo Zago-Schmitt, Joseph D. Schrag, Joel Smith, Patricia Zwierzchowski, Joshua M. Scurll, Vincent Fung, Sonia Black, Natalie C. J. Strynadka, Michael R. Gold, Leonard G. Presta, Gordon Ng, Surjit Dixit
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
The success of HER2-targeted cancer therapy is limited by treatment resistance. Here, the authors engineer an anti-HER2 biparatopic antibody with multiple mechanisms of action including induction of HER2 clustering to trigger complement dependent cyt
Externí odkaz:
https://doaj.org/article/8a871ad93e594eeba832492229b1329b
Autor:
Jaeyong Lee, Calem Kenward, Liam J. Worrall, Marija Vuckovic, Francesco Gentile, Anh-Tien Ton, Myles Ng, Artem Cherkasov, Natalie C. J. Strynadka, Mark Paetzel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The SARS-CoV-2 protease Mpro is essential for viral replication. Here, the authors have determined the structures of Mpro in complex with 10 of the 11 viral cleavage sequences including a covalent acyl-enzyme intermediate, providing mechanistic and s
Externí odkaz:
https://doaj.org/article/1bd44754c8b142a281ac22dd1d9222a1
Autor:
Jaeyong Lee, Liam J. Worrall, Marija Vuckovic, Federico I. Rosell, Francesco Gentile, Anh-Tien Ton, Nathanael A. Caveney, Fuqiang Ban, Artem Cherkasov, Mark Paetzel, Natalie C. J. Strynadka
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
The SARS-CoV-2 main protease (Mpro) is one of two cysteine proteases essential for viral replication. Here, the authors determine the crystal structure of an Mpro acyl intermediate with its native C-terminal autocleavage sequence and the structure of
Externí odkaz:
https://doaj.org/article/79fa01c0d7f04a9ab66a27ea9f850fb5
Autor:
Nathanael A. Caveney, Guillermo Caballero, Henri Voedts, Ana Niciforovic, Liam J. Worrall, Marija Vuckovic, Matthieu Fonvielle, Jean-Emmanuel Hugonnet, Michel Arthur, Natalie C. J. Strynadka
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
In E. coli, alternate peptidoglycan crosslinking reactions carried out by the L,D-transpeptidase YcbB can lead to beta-lactam resistance. Here, Caveney et al. solve the crystal structure of YcbB and shed light into its mechanism of action and into Yc
Externí odkaz:
https://doaj.org/article/5893b624e29f4e1b9969ad99f17cd15a
Autor:
Dorothy D. Majewski, Liam J. Worrall, Chuan Hong, Claire E. Atkinson, Marija Vuckovic, Nobuhiko Watanabe, Zhiheng Yu, Natalie C. J. Strynadka
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Many Gram-negative bacteria rely on a type III secretion system (T3SS) for their pathogenicity. Here authors present the cryo-EM structure of the E.coli T3SS ATPase-central stalk complex, which forms a homohexameric, asymmetric pore with different fu
Externí odkaz:
https://doaj.org/article/655ed92072524851b04d71448b77be1e
Autor:
Jessa P. Ata, Kelly S. Burns, Suzanne Marchetti, Isabel A. Munck, Ludwig Beenken, James J. Worrall, Jane E. Stewart
Publikováno v:
PeerJ, Vol 9, p e11435 (2021)
Increasing prevalence of conifer needle pathogens globally have prompted further studies on pathogen identification and a better understanding of phylogenetic relationships among needle pathogens. Several Lophodermella species can be aggressive patho
Externí odkaz:
https://doaj.org/article/c1827f80be774ea8a54b6186f3db7523