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Akademický článek

Glycyrrhizic Acid Prevents Paclitaxel-Induced Neuropathy via Inhibition of OATP-Mediated Neuronal Uptake

Autor: Ines Klein, Jörg Isensee, Martin H. J. Wiesen, Thomas Imhof, Meike K. Wassermann, Carsten Müller, Tim Hucho, Manuel Koch, Helmar C. Lehmann

Publikováno v: Cells, Vol 12, Iss 9, p 1249 (2023)

Peripheral neuropathy is a common side effect of cancer treatment with paclitaxel. The mechanisms by which paclitaxel is transported into neurons, which are essential for preventing neuropathy, are not well understood. We studied the uptake mechanism

Externí odkaz: https://doaj.org/article/ea8159b8f82d4bff9777993fe6df54a1

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Akademický článek

Monitoring of sedation depth in intensive care unit by therapeutic drug monitoring? A prospective observation study of medical intensive care patients

Autor: Richard J. Nies, Carsten Müller, Roman Pfister, Philipp S. Binder, Nicole Nosseir, Felix S. Nettersheim, Kathrin Kuhr, Martin H. J. Wiesen, Matthias Kochanek, Guido Michels

Publikováno v: Journal of Intensive Care, Vol 6, Iss 1, Pp 1-8 (2018)

Abstract Background Analgosedation is a cornerstone therapy for mechanically ventilated patients in intensive care units (ICU). To avoid inadequate sedation and its complications, monitoring of analgosedation is of great importance. The aim of this s

Externí odkaz: https://doaj.org/article/b2af1b341eb14780909e78e1a5d69cae

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Detection of systemic immunosuppressants in autologous serum eye drops (ASED) in patients with severe chronic ocular graft versus host disease

Autor: Michael E. Stern, Christof Scheid, Birgit S. Gathof, Udo Holtick, Philipp Steven, Laura Sauerbier, Carsten Müller, Volkan Tahmaz, Uta Gehlsen, Martin H. J. Wiesen

Publikováno v: Graefe's Archive for Clinical and Experimental Ophthalmology

Purpose Chronic graft versus host disease is a major consequence after allogeneic stem cell transplantation (allo-SCT) and has great impact on patients’ morbidity and mortality. Besides the skin, liver, and intestines, the eyes are most commonly af

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b2a50f3d411c895f0d9f77d54e6954
https://doi.org/10.1007/s00417-020-04865-8

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Impact of drug formulations on kinetics and toxicity in a preclinical model of paclitaxel-induced neuropathy

Autor: Ilja Bobylev, Abhijeet R. Joshi, Martin H. J. Wiesen, Ines Klein, Virginia Albert, Carsten Müller, Helmar C. Lehmann

Publikováno v: Journal of the peripheral nervous system : JPNSREFERENCES. 26(2)

Background and aims Peripheral neuropathy is a common side effect of paclitaxel. Clinical studies suggest that different paclitaxel formulations influence the severity and time course of paclitaxel-induced peripheral neuropathy. We compared two pacli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507d82736189aa11a41efa1e4fe713a0
https://pubmed.ncbi.nlm.nih.gov/33683765

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Extraocular Muscle Reveals Selective Vulnerability of Type IIB Fibers to Respiratory Chain Defects Induced by Mitochondrial DNA Alterations

Autor: Peter Zentis, David Pla-Martín, Rafael R. Oexner, Sammy Kimoloi, Astrid Schauss, Rudolf J. Wiesner, Martin H. J. Wiesen, Thomas Paß, Olivier R. Baris

Publikováno v: Investigative Ophthalmology & Visual Science
Investigative Ophthalmology & Visual Science, Association for Research in Vision and Ophthalmology, 2020, 61 (12), pp.14. ⟨10.1167/iovs.61.12.14⟩
Investigative Ophthalmology & Visual Science, 2020, 61 (12), pp.14. ⟨10.1167/iovs.61.12.14⟩

International audience; Purpose: The purpose of this study was to gain insights on the pathogenesis of chronic progressive external ophthalmoplegia, thus we investigated the vulnerability of five extra ocular muscles (EOMs) fiber types to pathogenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6d4edd741d894efdaccd75290c8537
https://hal.univ-angers.fr/hal-03003255/file/iovs-61-12-14.pdf

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Quantification of direct-acting oral anticoagulants: Application of a clinically validated liquid chromatography-tandem mass spectrometry method to forensic cases

Autor: Thomas Streichert, Stefanie Iwersen-Bergmann, Cornelia Fietz, Carsten Müller, Martin H. J. Wiesen, Hilke Andresen-Streichert, Martin Jübner

Publikováno v: Drug testing and analysisREFERENCES. 13(2)

In certain forensic cases, a quantification of direct-acting oral anticoagulants (DOACs) can be necessary. We evaluate the applicability of a previously described liquid chromatography-tandem mass spectrometry (LC-MS/MS) methodology for the determina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576bd71a6a1a364d38edfceb084066e7
https://pubmed.ncbi.nlm.nih.gov/32959964

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Akademický článek

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The Direct Factor Xa Inhibitor Rivaroxaban Passes Into Human Breast Milk

Autor: Roman Pfister, Carsten Müller, Martin H. J. Wiesen, Guido Michels, Cornelia Blaich, Thomas Streichert

Publikováno v: Chest. 150:e1-e4

Thromboembolic disorders frequently require antithrombotic treatment during pregnancy and lactation. Vitamin K antagonists and heparins are the treatment options of choice in breastfeeding women. Factors including the route of administration, discomf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8aea0828011e1148a9e730e38d5c02
https://doi.org/10.1016/j.chest.2016.01.021

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