Zobrazeno 1 - 10
of 191
pro vyhledávání: '"J, Wendorff"'
Autor:
Nicholas P. D. Liau, Matthew C. Johnson, Saeed Izadi, Luca Gerosa, Michal Hammel, John M. Bruning, Timothy J. Wendorff, Wilson Phung, Sarah G. Hymowitz, Jawahar Sudhamsu
Publikováno v:
Nature, vol 609, iss 7926
The RAS–RAF pathway is one of the most commonly dysregulated in human cancers1–3. Despite decades of study, understanding of the molecular mechanisms underlying dimerization and activation4 of the kinase RAF remains limited. Recent structures of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e51a0de8d7d289a691da380751102e
https://doi.org/10.1038/s41586-022-04838-3
https://doi.org/10.1038/s41586-022-04838-3
Autor:
Timothy J Wendorff, James M Berger
Publikováno v:
eLife, Vol 7 (2018)
Type II topoisomerases manage DNA supercoiling and aid chromosome segregation using a complex, ATP-dependent duplex strand passage mechanism. Type IIB topoisomerases and their homologs support both archaeal/plant viability and meiotic recombination.
Externí odkaz:
https://doaj.org/article/f692e0d3cc59404f972113f45c7c40a1
Publikováno v:
Molecular Cancer Research. 21:A036-A036
The RAS-RAF-MEK-ERK signaling axis is upregulated in many human cancers due to its central role in cell growth, differentiation and survival. Oncogenic transformation frequently arises from RAS, BRAF and MEK mutations that activate the pathway. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b8d8435225e8df537f57818b32abd4e
https://doi.org/10.1158/1557-3125.ras23-a036
https://doi.org/10.1158/1557-3125.ras23-a036
Autor:
Markus D. Schofer, S. Fuchs-Winkelmann, C. Wack, M. Rudisile, R. Dersch, I. Leifeld, J. Wendorff, A. Greiner, J. R. J. Paletta, U. Boudriot
Publikováno v:
The Scientific World Journal, Vol 9, Pp 313-319 (2009)
Growth factors like bone morphogenetic protein 2 (BMP-2) and vascular endothelial growth factor (VEGF) play an important role in bone remodeling and fracture repair. Therefore, with respect to tissue engineering, an artificial graft should have no ne
Externí odkaz:
https://doaj.org/article/2a6e740103f443668982c7d193a31aee
Autor:
Stephen Schmidt, Steve Sideris, Emily J. Hanan, Eric Torres, Jawahar Sudhamsu, Kyung Song, Lan K. Nguyen, Kyle A. Edgar, Nicholas F. Endres, Timothy J. Wendorff, Georgia Hatzivassiliou, Akash Das, Noriko Ishisoko, Lori Friedman, Victorai Schutz, Matt Saabye, Steven T. Staben, Hans E. Purkey, Divya Murali
Publikováno v:
Molecular Cancer Research. 18:PR03-PR03
Activating mutations in PIK3CA are among the most significant oncogenic events across all cancers, making it an important target for drug development. Yet the application of PI3K inhibitors in the clinic has been limited by the difficulty of achievin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1a6b9ac7d7bfe875ca0ea122685bcfc
https://doi.org/10.1158/1557-3125.pi3k-mtor18-pr03
https://doi.org/10.1158/1557-3125.pi3k-mtor18-pr03
Autor:
James M. Berger, Timothy J. Wendorff
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
Type II topoisomerases manage DNA supercoiling and aid chromosome segregation using a complex, ATP-dependent duplex strand passage mechanism. Type IIB topoisomerases and their homologs support both archaeal/plant viability and meiotic recombination.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c9346a441a4b44beafc24582293ecbe
http://europepmc.org/articles/PMC5922973
http://europepmc.org/articles/PMC5922973
Publikováno v:
Biophysical Journal. 102(9):2022-2030
Vinculin phosphorylation has been implicated as a potential mechanism for focal adhesion growth and maturation. Four vinculin residues—Y100, S1033, S1045, and Y1065—are phosphorylated by kinases during focal adhesion maturation. In this study, ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10b39bad974289cd79f6b605390b09e
Autor:
Ruth M. Saecker, Jonathan G. Cannon, Megan Kratz, Laurel M. Pegram, Timothy J. Wendorff, Demian Riccardi, Michael W. Capp, M. Thomas Record
Publikováno v:
Biochemistry. 48:10372-10379
Noncovalent self-assembly of biopolymers is driven by molecular interactions between functional groups on complementary biopolymer surfaces, replacing interactions with water. Since individually these interactions are comparable in strength to intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771e95a7c22ca0a706ddba8a97825b62
https://doi.org/10.1021/bi901273r
https://doi.org/10.1021/bi901273r
Publikováno v:
Macromolecular Chemistry and Physics. 210:1201-1209
Two hybrid polymers, poly(methylsilsesquioxane)-poly(2,2-diethoxyethyl acrylate) and poly-(methylsilsesquioxane)-poly(1,3-dioxolan-2-ylmethyl acrylate), were synthesized and used for preparation of stable surface coatings. Their acetal side groups co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c18f5a6453992a6bef64652c6f231d20
https://doi.org/10.1002/macp.200900156
https://doi.org/10.1002/macp.200900156