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pro vyhledávání: '"J, Weigelt"'
Akademický článek
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Akademický článek
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Publikováno v:
Proceedings of the 24th International Transport and Air Pollution (TAP) Conference
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::f1b8f5cbebd411d2d3f314bb50b652ff
Autor:
Herwig Schüler, J. Weigelt, Antonio Macchiarulo, Delal Öncü, Ann-Gerd Thorsell, Roberto Pellicciari, Björn Kull, T. Ekblad, Elisabet Wahlberg, Ewa Pol, Åsa Frostell, Tobias Karlberg, Graeme M. Robertson, N. Markova, Ekaterina Kouznetsova
Publikováno v:
Nature Biotechnology. 30:283-288
Inhibitors of poly-ADP-ribose polymerase (PARP) family proteins are currently in clinical trials as cancer therapeutics, yet the specificity of many of these compounds is unknown. Here we evaluated a series of 185 small-molecule inhibitors, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c25e1488947e8761f7d72305146511e
https://doi.org/10.1038/nbt.2121
https://doi.org/10.1038/nbt.2121
Autor:
J. Weigelt, Rosanna W. Peeling, D.J. Payne, Anthony D. So, Bernard H. Munos, Samir K. Brahmachari, Carl Nathan, J.P. Paccaud, Neha Gupta, Ian Chopra, M. Spigelman, Kevin Outterson
Publikováno v:
Drug Resistance Updates. 14:88-94
In the face of a growing global burden of resistance to existing antibiotics, a combination of scientific and economic challenges has posed significant barriers to the development of novel antibacterials over the past few decades. Yet the bottlenecks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9d2fe5bb725056fad12a5246e534e3
https://doi.org/10.1016/j.drup.2011.01.006
https://doi.org/10.1016/j.drup.2011.01.006
Autor:
Michael Sundström, Alexander Kotzsch, J. Weigelt, Erik Vernet, Susanne Gräslund, Martin Hammarström, Jens Berthelsen
Publikováno v:
Protein Science. 20:597-609
Escherichia coli represents a robust, inexpensive expression host for the production of recombinant proteins. However, one major limitation is that certain protein classes do not express well in a biologically relevant form using standard expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e14328e969fe81fdc29aef07469f7862
https://doi.org/10.1002/pro.593
https://doi.org/10.1002/pro.593
Publikováno v:
Protein Expression and Purification. 72:175-178
Structural and biochemical analysis of proteins requires access to purified protein material. Modern molecular biology technologies facilitate straightforward molecular cloning and expression analysis of multiple protein constructs in parallel, and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0862af545b0337993edd071d940ea79
https://doi.org/10.1016/j.pep.2010.03.020
https://doi.org/10.1016/j.pep.2010.03.020
Autor:
J. Weigelt, Tobias Karlberg, Martin Hammarström, Ida Johansson, Herwig Schüler, P. Schutz, N. Markova
Publikováno v:
Journal of Medicinal Chemistry. 53:5352-5355
We report two crystal structures of the PARP domain of human tankyrase-2 (TNKS2). Tankyrases are involved in fundamental cellular processes such as telomere homeostasis and Wnt signaling. The complex of TNKS2 with the potent inhibitor XAV939 provides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69ba4f1c7e7655d6e36809885b8bc75
https://doi.org/10.1021/jm100249w
https://doi.org/10.1021/jm100249w
Autor:
J. Weigelt
Publikováno v:
Experimental Cell Research. 316:1332-1338
The field of structural genomics emerged as one of many 'omics disciplines more than a decade ago, and a multitude of large scale initiatives have been launched across the world. Development and implementation of methods for high-throughput structura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906650764e8b52da2c4f1a77169e6b71
https://doi.org/10.1016/j.yexcr.2010.02.041
https://doi.org/10.1016/j.yexcr.2010.02.041
Autor:
J. Weigelt
Publikováno v:
EMBO reports. 10:941-945
Policy‐makers and scientists are increasingly worried about the declining productivity of the pharmaceutical industry. Despite growing levels of investment from governments and industry, the number of new medicines that are approved each year has d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ecadd26bd2d1aba83ac73e6e5dd963
https://doi.org/10.1038/embor.2009.193
https://doi.org/10.1038/embor.2009.193