Zobrazeno 1 - 10
of 992
pro vyhledávání: '"J, Weigel"'
Autor:
Stuart L. Cramer, Alyssa Terry Reddy, Charles Gene Minard, Stephan Voss, Elizabeth Fox, Xiaowei Liu, Kristina Denic, Joel M. Reid, Brenda J. Weigel
Publikováno v:
Cancer Medicine, Vol 13, Iss 21, Pp n/a-n/a (2024)
ABSTRACT Background Nab‐sirolimus (ABI‐009, nab‐rapamycin; Aadi Bioscience Inc. [Aadi]) is a human albumin‐bound form of sirolimus nanoparticles, a potent mTOR inhibitor. This phase I trial was conducted to define dose‐limiting toxicities (
Externí odkaz:
https://doaj.org/article/dd2e1f92a073437a871a697c5f52e013
Autor:
Rose H. Dicovitsky, Jill T. Schappa, Ashley J. Schulte, Haeree P. Lang, Ellen Kuerbitz, Sarah Roberts, Taylor A. DePauw, Mitzi Lewellen, Amber L. Winter, Kathy Stuebner, Michelle Buettner, Kelly Reid, Kelly Bergsrud, Sara Pracht, Andrea Chehadeh, Caitlin Feiock, M. Gerard O’Sullivan, Tim Carlson, Alexandra R. Armstrong, Danielle Meritet, Michael S. Henson, Brenda J. Weigel, Jaime F. Modiano, Antonella Borgatti, Daniel A. Vallera
Publikováno v:
Toxins, Vol 16, Iss 9, p 376 (2024)
EGFR-targeted therapies are efficacious, but toxicity is common and can be severe. Urokinase type plasminogen activator receptor (uPAR)-targeted drugs are only emerging, so neither their efficacy nor toxicity is fully established. Recombinant eBAT wa
Externí odkaz:
https://doaj.org/article/6505ce6cd7b5471f92672f457ebc37f6
Autor:
Damian N. Di Florio, Logan P. Macomb, Presley G. Giresi, Danielle J. Beetler, Natalie E. Bonvie-Hill, Katie A. Shapiro, Abdel-Rahman N. Naser, Sami Khatib, Emily R. Whelan, Gabriel J. Weigel, Brandy H. Edenfield, Varsini Balamurugan, Sarah K. Burris, Laurie J. Rich, Katelyn A. Bruno, Leslie T. Cooper, Jr., Chris J. McLeod, Mohamad H. Yamani, DeLisa Fairweather
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108493- (2023)
Summary: Myocarditis is typically caused by viral infections, but most cases are thought to be subclinical. Echocardiography is often used for initial assessment of myocarditis patients but is poor at detecting subtle changes in cardiac dysfunction.
Externí odkaz:
https://doaj.org/article/feefc1a478c8478fa4f903603f6ea217
Autor:
Virginia E. Glazier, Juraj Kramara, Tomye Ollinger, Norma V. Solis, Robert Zarnowski, Rohan S. Wakade, Min-Ju Kim, Gabriel J. Weigel, Shen-Huan Liang, Richard J. Bennett, Melanie Wellington, David R. Andes, Mark A. Stamnes, Scott G. Filler, Damian J. Krysan
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Candida albicans is a diploid human fungal pathogen that displays significant genomic and phenotypic heterogeneity over a range of virulence traits and in the context of a variety of environmental niches. Here, we show that the effect of Rob
Externí odkaz:
https://doaj.org/article/d9d88ba2cedc4442aa5ec5ea0648059b
Autor:
Fernando López-Gatius, Irina Garcia-Ispierto, Sergi Ganau, Robert Wijma, Daniel J. Weigel, Fernando A. Di Croce
Publikováno v:
Animals, Vol 13, Iss 12, p 2008 (2023)
Twin pregnancies are highly undesirable in dairy cattle; they compromise the health and wellbeing of a cow and dramatically impair the farm economy. Recently, a genomic prediction for twin pregnancies has been developed. The objective of this study w
Externí odkaz:
https://doaj.org/article/c86fde0e364143619dd5c72cba07f31f
Autor:
Douglas J. Harrison, Yueh‐Yun Chi, Jing Tian, Pooja Hingorani, Leo Mascarenhas, Geoffrey B. McCowage, Brenda J. Weigel, Rajkumar Venkatramani, Suzanne L. Wolden, Torunn I. Yock, David A. Rodeberg, Andrea A. Hayes‐Jordan, Lisa A. Teot, Sheri L. Spunt, William H. Meyer, Douglas S. Hawkins, Barry L. Shulkin, Marguerite T. Parisi
Publikováno v:
Cancer Medicine, Vol 10, Iss 3, Pp 857-866 (2021)
ABSTRACT Background Strategies to optimize management in rhabdomyosarcoma (RMS) include risk stratification to assign therapy aiming to minimize treatment morbidity yet improve outcomes. This analysis evaluated the relationship between complete metab
Externí odkaz:
https://doaj.org/article/312b8738271c49eb906d6d54f8fea79b
Autor:
Leo Mascarenhas, Chitose Ogawa, Theodore W. Laetsch, Brenda J. Weigel, Michael W. Bishop, Julie Krystal, Scott C. Borinstein, Emily K. Slotkin, Jodi A. Muscal, Pooja Hingorani, Donna E. Levy, Gary Mo, Ashwin Shahir, Jennifer Wright, Steven G. DuBois
Publikováno v:
Cancer Medicine, Vol 10, Iss 3, Pp 843-856 (2021)
Abstract Olaratumab is a monoclonal antibody that specifically binds to platelet‐derived growth factor receptor alpha (PDGFRα) and blocks receptor activation. We conducted a phase 1 trial to evaluate the safety of olaratumab and determine a recomm
Externí odkaz:
https://doaj.org/article/728f5f60eab94b5f8c5a384248851207
Publikováno v:
JCI Insight, Vol 6, Iss 18 (2021)
GPCRs are highly desirable drug targets for human disease. Although GPCR dysfunction drives development and progression of many tumors, including breast cancer (BC), targeting individual GPCRs has limited efficacy as a cancer therapy because numerous
Externí odkaz:
https://doaj.org/article/e847b129bf434051bc84d8e6abd7ee2b
Autor:
Xueke Shi, Jingjing Luo, Kelsey J. Weigel, Spencer C. Hall, Danfeng Du, Fanglong Wu, Michael C. Rudolph, Hongmei Zhou, Christian D. Young, Xiao-Jing Wang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Cancer-associated fibroblasts (CAFs) have been shown to enhance squamous cell carcinoma (SCC) growth, but it is unclear whether they promote SCC lung metastasis. We generated CAFs from K15.KrasG12D.Smad4–/– mouse SCCs. RNA expression analyses dem
Externí odkaz:
https://doaj.org/article/19de65004c584648918e885d23a14ec2
Autor:
Simon Roh, Mark D. Iannettoni, John Keech, Evgeny V. Arshava, Anthony Swatek, Miriam B. Zimmerman, Ronald J. Weigel, Kalpaj R. Parekh
Publikováno v:
Korean Journal of Thoracic and Cardiovascular Surgery, Vol 52, Iss 1, Pp 1-8 (2019)
Background: Neoadjuvant chemoradiation therapy (nCRT) has become the standard of care for esophageal cancer patients prior to esophagectomy. However, the optimal timing for surgery after completion of nCRT remains unclear. Methods: A retrospective re
Externí odkaz:
https://doaj.org/article/d168efee95254d29b895c3e71e0151a5