EVA implants for controlled drug delivery to the inner ear

Autor: Y. Bedulho das Lages, N. Milanino, J. Verin, J.F. Willart, F. Danede, C. Vincent, P. Bawuah, J.A. Zeitler, F. Siepmann, J. Siepmann

Publikováno v: International Journal of Pharmaceutics: X, Vol 8, Iss , Pp 100271- (2024)

This study evaluated the potential of poly(ethylene vinyl acetate) (EVA) copolymers as matrix formers in miniaturised implants, allowing to achieve controlled drug delivery into the inner ear. Due to the blood-cochlea barrier, it is impossible to rel

Externí odkaz: https://doaj.org/article/e736761ac5e84a638d27e909f0f71710

Drug release from PLGA microparticles can be slowed down by a surrounding hydrogel

Autor: L.A. Lefol, P. Bawuah, J.A. Zeitler, J. Verin, F. Danede, J.F. Willart, F. Siepmann, J. Siepmann

Publikováno v: International Journal of Pharmaceutics: X, Vol 6, Iss , Pp 100220- (2023)

This study aimed to evaluate and better understand the potential impact that a layer of surrounding hydrogel (mimicking living tissue) can have on the drug release from PLGA microparticles. Ibuprofen-loaded microparticles were prepared with an emulsi

Externí odkaz: https://doaj.org/article/8eab003d5b2b4d1682a8b314fd2498b0

How bulk fluid renewal can affect in vitro drug release from PLGA implants: Importance of the experimental set-up

Autor: C. Bassand, L. Benabed, J. Freitag, J. Verin, F. Siepmann, J. Siepmann

Publikováno v: International Journal of Pharmaceutics: X, Vol 4, Iss , Pp 100131- (2022)

The aim of this study was to better understand the potential impact of partial vs. complete renewal of the bulk fluid during drug release measurements from poly (lactic-co-glycolic acid) (PLGA)-based implants. A “standard experimental set-up”, in

Externí odkaz: https://doaj.org/article/07fdb73679b04890ba492924779bf1e8

3D printed PLGA implants: APF DDM vs. FDM

Autor: C, Bassand, L, Benabed, S, Charlon, J, Verin, J, Freitag, F, Siepmann, J, Soulestin, J, Siepmann

Publikováno v: Journal of Controlled Release
Journal of Controlled Release, 2022, Journal of Controlled Release, 353, pp.864-874. ⟨10.1016/j.jconrel.2022.11.052⟩

International audience; 3D Printing offers a considerable potential for personalized medicines. This is especially true for customized biodegradable implants, matching the specific needs of each patient. Poly(lactic-co-glycolic acid) (PLGA) is freque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d37674478e6f76c6aba8b07b6d6bf54
https://doi.org/10.1016/j.jconrel.2022.11.052

How agarose gels surrounding PLGA implants limit swelling and slow down drug release

Autor: C, Bassand, J, Verin, M, Lamatsch, F, Siepmann, J, Siepmann

Publikováno v: Journal of Controlled Release. 343:255-266

The aim of this study was to better understand to which extent and in which way the presence of an agarose gel (mimicking living tissue) around a PLGA [poly(lactic-co-glycolic acid)] implant affects the resulting drug release kinetics. Ibuprofen-load

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6181b379967ca1b37fabbe113731597e
https://doi.org/10.1016/j.jconrel.2022.01.028