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In vitro metabolism of the HIV-1 protease inhibitor ABT-378: species comparison and metabolite identification

Autor: G N, Kumar, V, Jayanti, R D, Lee, D N, Whittern, J, Uchic, S, Thomas, P, Johnson, B, Grabowski, H, Sham, D, Betebenner, D J, Kempf, J F, Denissen

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 27(1)

HIV protease inhibitor ABT-378 (ABT-378) was metabolized very extensively and rapidly by liver microsomes from mouse, rat, dog, monkey, and humans. The rates of NADPH-dependent metabolism of ABT-378 ranged from 2.39 to 9.80 nmol.mg microsomal protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c6f6181a104e68c5d9f610c175157dc
https://pubmed.ncbi.nlm.nih.gov/9884314

In vitro metabolism of the HIV-1 protease inhibitor ABT-378: species comparison and metabolite identification.

Autor: N, Kumar G, V, Jayanti, D, Lee R, N, Whittern D, J, Uchic, S, Thomas, P, Johnson, B, Grabowski, H, Sham, D, Betebenner, J, Kempf D, F, Denissen J

Publikováno v: Drug Metabolism and Disposition; January 1999, Vol. 27 Issue: 1 p86-91, 6p

An alignment algorithm using coherent twin boundaries as internal reference in 3D-EBSD.

Autor: Li H; School of Materials Science and Engineering, Shanghai University, Shanghai, PR China.; State Key Laboratory of Advanced Special Steel, Shanghai University, Shanghai, PR China., Xia S; School of Materials Science and Engineering, Shanghai University, Shanghai, PR China.; State Key Laboratory of Advanced Special Steel, Shanghai University, Shanghai, PR China., Bai Q; School of Materials Science and Engineering, Shanghai University, Shanghai, PR China.; Key Laboratory for Microstructures, Shanghai University, Shanghai, PR China., Liu T; National Center for Materials Service Safety, University of Science and Technology Beijing, Beijing, PR China., Zhang Y; School of Materials Science and Engineering, Shanghai University, Shanghai, PR China.; State Key Laboratory of Advanced Special Steel, Shanghai University, Shanghai, PR China.

Publikováno v: Journal of microscopy [J Microsc] 2025 Jan; Vol. 297 (1), pp. 43-56. Date of Electronic Publication: 2024 Aug 16.

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