Výsledky vyhledávání

Elektronická kniha

Autor: Egbertus Van Gulik, James K. McConica, j. Trapman

What became of Erasmus'books? The most famous scholar of his day died in peaceful prosperity and in the company of celebrated and responsible friends. His zeal for useful books was insatiable. Indeed, he had taken care to insure that after his death

Zobrazit plný text záznamu

Discriminating somatic and germline mutations in tumor DNA samples without matching normals

Autor: Peter J. van der Spek, G. Jenster, J. Trapman, Andrew P. Stubbs, Saskia Hiltemann

Publikováno v: Genome Research, 25(9), 1382-1390. Cold Spring Harbor Laboratory Press

Tumor analyses commonly employ a correction with a matched normal (MN), a sample from healthy tissue of the same individual, in order to distinguish germline mutations from somatic mutations. Since the majority of variants found in an individual are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::befff33ebe9d9ff918f37267d8c152a1
https://pure.eur.nl/en/publications/e5772844-b26a-4490-9696-ed7e1749fb11

Zobrazit plný text záznamu

Next-generation sequencing reveals novel rare fusion events with functional implication in prostate cancer

Autor: Thomas A Hartjes, P. J. van der Spek, G. Jenster, A. de Klein, I Teles Alves, Bart J. Janssen, M R Temanni, J. Trapman, Bert Eussen, Andrew P. Stubbs, W van Workum, René Böttcher, Saskia Hiltemann, Elizabeth A. McClellan, N Dits

Publikováno v: Oncogene
Oncogene, 34(5), 568-577. Nature Publishing Group

Gene fusions, mainly between TMPRSS2 and ERG, are frequent early genomic rearrangements in prostate cancer (PCa). In order to discover novel genomic fusion events, we applied whole-genome paired-end sequencing to identify structural alterations prese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485214fb72fd06752516182659b65015

Zobrazit plný text záznamu

Gene fusions by chromothripsis of chromosome 5q in the VCaP prostate cancer cell line

Autor: Peter J. van der Spek, Saskia Hiltemann, Inês Teles Alves, G. Jenster, Thomas A Hartjes, J. Trapman, Andrew P. Stubbs

Publikováno v: Human Genetics, 132(6), 709-713. Springer-Verlag
OpenAIRE

The VCaP cell line is widely used in prostate cancer research as it is a unique model to study castrate resistant disease expressing high levels of the wild type androgen receptor and the TMPRSS2-ERG fusion transcript. Using next generation sequencin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f07d2d718590c4e9d59fdeef88486bd
https://pure.eur.nl/en/publications/7c2e0637-5eb9-4f1b-9bc9-655c343da73f

Zobrazit plný text záznamu

Immunohistochemical ETS-related gene detection in a Japanese prostate cancer cohort: Diagnostic use in Japanese prostate cancer patients

Autor: Takahiro Kimura, Hiroyuki Takahashi, Geert J.H.L. van Leenders, Masakuni Furusato, Hiroshi Hano, Bungo Furusato, Shin Egawa, Tapio Visakorpi, J. Trapman

Publikováno v: Pathology International. 61:409-414

Chromosomal rearrangements that result in high expression levels of the ETS-related gene (ERG) present in approximately 50% of prostate cancer (PCa) patients, making this one of the most common oncogenic alterations in PCa. However, ERG overexpressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::812b2566bcc88db0b0a26827b4b3e2d8
https://doi.org/10.1111/j.1440-1827.2011.02675.x

Zobrazit plný text záznamu

PTEN-mediated G1 cell-cycle arrest in LNCaP prostate cancer cells is associated with altered expression of cell-cycle regulators

Autor: J. Trapman, A.C.J. Ziel-van der Made, P.W. van Duijn, J.A.G. van der Korput

Publikováno v: The Prostate. 70:135-146

BACKGROUND The tumor suppressor PTEN regulates many biological processes. A well-known downstream effector of PTEN is phospho-Akt. Although PTEN is the most frequently inactivated gene in prostate cancer, its mode of action is not fully understood. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81ce5228ddbc6005808883298b36b0de
https://doi.org/10.1002/pros.21045

Zobrazit plný text záznamu

PI3K/Akt signaling regulates p27kip1 expression via Skp2 in PC3 and DU145 prostate cancer cells, but is not a major factor in p27kip1 regulation in LNCaP and PC346 cells

Autor: J. Trapman, Petra W. van Duijn

Publikováno v: The Prostate. 66:749-760

BACKGROUND We compared the involvement of PI3K/PTEN/Akt signaling in the regulation of the cell-cycle regulator p27kip1 and investigated the mechanism of PI3K/PTEN/Akt modulation of p27kip1 in the prostate cancer cell lines LNCaP, PC346, PC3, and DU1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c1feed024647303b1b568d8443f78d
https://doi.org/10.1002/pros.20398

Zobrazit plný text záznamu

Variable Loss of Functional Activities of Androgen Receptor Mutants in Patients with Androgen Insensitivity Syndrome

Autor: Stenvert L. S. Drop, Trevor Bunch, E.L.T. van den Akker, R. Bosch, Adriaan B Houtsmuller, Hennie T. Brüggenwirth, J. Trapman, Scott J. Lusher, Wilma Oostdijk, Albert O. Brinkmann, M.C.M. Bunck, Sultana M.H. Faradz, Ieuan A. Hughes, P.H. Bisschop, Martine Cools, M.E. van Royen, P. Elfferich, D.J. van de Wijngaart

Publikováno v: Elfferich, P, van Royen, M E, van de Wijngaart, D J, Trapman, J, Drop, S L S, van den Akker, E L T, Lusher, S J, van den Bosch, R, Bunch, T, Hughes, I A, Houtsmuller, AB, Cools, M, Faradz, S M H, Bisschop, P H, Bunck, M C M, Oostdijk, W, Bruggenwirth, H T & Brinkmann, A O 2013, ' Variable Loss of Functional Activities of Androgen Receptor Mutants in Patients with Androgen Insensitivity Syndrome ', Sexual development, vol. 7, no. 5, pp. 223-234 . https://doi.org/10.1159/000351820
Sexual development, 7(5), 223-234. S. Karger AG
Sexual Development, 7(5), 223-234
Sexual Development, 7(5), 223-234. Karger

Androgen receptor (AR) mutations in androgen insensitivity syndrome (AIS) are associated with a variety of clinical phenotypes. The aim of the present study was to compare the molecular properties and potential pathogenic nature of 8 novel and 3 recu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4623fb93e46693d283f6d4d7df2dd94b
https://research.vumc.nl/en/publications/a64736af-c639-4344-8f97-b52dc2178934

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání