Zobrazeno 1 - 10
of 490
pro vyhledávání: '"J, Towers"'
Publikováno v:
Retrovirology, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Background Detection of viruses by host pattern recognition receptors induces the expression of type I interferon (IFN) and IFN-stimulated genes (ISGs), which suppress viral replication. Numerous studies have described HIV-1 as a poor activa
Externí odkaz:
https://doaj.org/article/6d27326a2da4481b82ccd12716fb9fdd
Autor:
Ouli Xie, Jacqueline M. Morris, Andrew J. Hayes, Rebecca J. Towers, Magnus G. Jespersen, John A. Lees, Nouri L. Ben Zakour, Olga Berking, Sarah L. Baines, Glen P. Carter, Gerry Tonkin-Hill, Layla Schrieber, Liam McIntyre, Jake A. Lacey, Taylah B. James, Kadaba S. Sriprakash, Scott A. Beatson, Tadao Hasegawa, Phil Giffard, Andrew C. Steer, Michael R. Batzloff, Bernard W. Beall, Marcos D. Pinho, Mario Ramirez, Debra E. Bessen, Gordon Dougan, Stephen D. Bentley, Mark J. Walker, Bart J. Currie, Steven Y. C. Tong, David J. McMillan, Mark R. Davies
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Streptococcus dysgalactiae subsp. equisimilis (SDSE) is an emerging cause of human infection with invasive disease incidence and clinical manifestations comparable to the closely related species, Streptococcus pyogenes. Through systematic ge
Externí odkaz:
https://doaj.org/article/64c2683511e049649c96119d191110c7
Autor:
KM Rifat Faysal, James C Walsh, Nadine Renner, Chantal L Márquez, Vaibhav B Shah, Andrew J Tuckwell, Michelle P Christie, Michael W Parker, Stuart G Turville, Greg J Towers, Leo C James, David A Jacques, Till Böcking
Publikováno v:
eLife, Vol 13 (2024)
The HIV-1 capsid has emerged as a tractable target for antiretroviral therapy. Lenacapavir, developed by Gilead Sciences, is the first capsid-targeting drug approved for medical use. Here, we investigate the effect of lenacapavir on HIV capsid stabil
Externí odkaz:
https://doaj.org/article/08ba42401fe84baebde255dedc84b832
Autor:
Douglas L. Fink, James Cai, Matthew V. X. Whelan, Christopher Monit, Carlos Maluquer de Motes, Greg J. Towers, Rebecca P. Sumner
Publikováno v:
Retrovirology, Vol 19, Iss 1, Pp 1-14 (2022)
Abstract Background The NF-κB family of transcription factors and associated signalling pathways are abundant and ubiquitous in human immune responses. Activation of NF-κB transcription factors by viral pathogen-associated molecular patterns, such
Externí odkaz:
https://doaj.org/article/83664ea4d57d46588314b53c167d7d2b
Autor:
Carolina B. Ferreira, Rebecca P. Sumner, Maria T. Rodriguez-Plata, Jane Rasaiyaah, Richard S. Milne, Adrian J. Thrasher, Waseem Qasim, Greg J. Towers
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 209-219 (2020)
Most gene therapy lentiviral vector (LV) production platforms employ HEK293T cells expressing the oncogenic SV40 large T-antigen (TAg) that is thought to promote plasmid-mediated gene expression. Studies on other viral oncogenes suggest that TAg may
Externí odkaz:
https://doaj.org/article/5ec497afb24c436c8f1efc7f27c66a59
Autor:
Charles R. Dixon, Poonam Malik, Jose I. de las Heras, Natalia Saiz-Ros, Flavia de Lima Alves, Mark Tingey, Eleanor Gaunt, A. Christine Richardson, David A. Kelly, Martin W. Goldberg, Greg J. Towers, Weidong Yang, Juri Rappsilber, Paul Digard, Eric C. Schirmer
Publikováno v:
iScience, Vol 24, Iss 9, Pp 103055- (2021)
Summary: STimulator of INterferon Genes (STING) is an adaptor for cytoplasmic DNA sensing by cGAMP/cGAS that helps trigger innate immune responses (IIRs). Although STING is mostly localized in the ER, we find a separate inner nuclear membrane pool of
Externí odkaz:
https://doaj.org/article/7c77bb3feb48478187feaae2f2cec97e
Publikováno v:
BMC Evolutionary Biology, Vol 19, Iss 1, Pp 1-4 (2019)
Abstract Background Studying site-specific amino acid frequencies by eye can reveal biologically significant variability and lineage-specific adaptation. This so-called ‘sequence gazing’ often informs bioinformatics and experimental research. But
Externí odkaz:
https://doaj.org/article/99780ea4862d4cacaa9aa3e33c2f2ec7
Autor:
Rawlings Datir, Steven Kemp, Kate El Bouzidi, Petra Mlchocova, Richard Goldstein, Judy Breuer, Greg J. Towers, Clare Jolly, Miguel E. Quiñones-Mateu, Patrick S. Dakum, Nicaise Ndembi, Ravindra K. Gupta
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT Protease inhibitors (PIs) are the second- and last-line therapy for the majority of HIV-infected patients worldwide. Only around 20% of individuals who fail PI regimens develop major resistance mutations in protease. We sought to explore the
Externí odkaz:
https://doaj.org/article/7199b87aeca649fba51303efebde939d
Autor:
Hataf Khan, Rebecca P Sumner, Jane Rasaiyaah, Choon Ping Tan, Maria Teresa Rodriguez-Plata, Chris Van Tulleken, Douglas Fink, Lorena Zuliani-Alvarez, Lucy Thorne, David Stirling, Richard SB Milne, Greg J Towers
Publikováno v:
eLife, Vol 9 (2020)
HIV-1 must replicate in cells that are equipped to defend themselves from infection through intracellular innate immune systems. HIV-1 evades innate immune sensing through encapsidated DNA synthesis and encodes accessory genes that antagonize specifi
Externí odkaz:
https://doaj.org/article/a655391dba6548b0b54ade4c8ae5e3b2
Autor:
Che C Colpitts, Sophie Ridewood, Bethany Schneiderman, Justin Warne, Keisuke Tabata, Caitlin F Ng, Ralf Bartenschlager, David L Selwood, Greg J Towers
Publikováno v:
eLife, Vol 9 (2020)
Counteracting innate immunity is essential for successful viral replication. Host cyclophilins (Cyps) have been implicated in viral evasion of host antiviral responses, although the mechanisms are still unclear. Here, we show that hepatitis C virus (
Externí odkaz:
https://doaj.org/article/c5ebac21d95640d5911709dfca419d5e