Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Target engagement and intracellular delivery of mono- and bivalent LDL receptor-binding peptide-cargo conjugates: Implications for the rational design of new targeted drug therapies

Autor: Karine Varini, F. Gassiot, M. David, P. Lecorche, A. Faucon, B. Broc, M. Godard, Géraldine Ferracci, Michel Khrestchatisky, J. Temsamani, R. Sonnette, K. Abouzid, G. Jacquot

Publikováno v: Journal of Controlled Release
Journal of Controlled Release, 2019, 314, pp.141-161. ⟨10.1016/j.jconrel.2019.10.033⟩
Journal of Controlled Release, Elsevier, 2019, 314, pp.141-161. ⟨10.1016/j.jconrel.2019.10.033⟩

Targeted delivery to specific tissues and subcellular compartments is of paramount importance to optimize therapeutic or diagnostic interventions while minimizing side-effects. Using recently identified LDL receptor (LDLR) -targeting small synthetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b368b54b4ad30626a409e0a19c9efbee
https://hal.science/hal-02348680

Comparison of in Vitro Transcriptions Using Various Types of DNA Templates

Autor: V. Kohli, J. Temsamani

Publikováno v: Analytical Biochemistry. 208:223-227

Improvements in the synthesis of RNA using T7 RNA polymerase and synthetic deoxyoligonucleotides containing the T7 RNA promoter are described. Yields were highest when the double-stranded promoter was generated from a hairpin hybridized to the single

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13706b8d6187fd38bdfbccd5fb6c3ed2
https://doi.org/10.1006/abio.1993.1036

Capped Oligodeoxynucleotide Phosphorothioates

Autor: Sudhir Agrawal, J.-Y. Tang, J. Temsamani

Publikováno v: Annals of the New York Academy of Sciences. 660:318-320

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81faff1450822badff8c6c4f05bc9777
https://doi.org/10.1111/j.1749-6632.1992.tb21099.x

Enhanced delivery of doxorubicin into the brain via a peptide-vector-mediated strategy: saturation kinetics and specificity

Autor: C, Rousselle, M, Smirnova, P, Clair, J M, Lefauconnier, A, Chavanieu, B, Calas, J M, Scherrmann, J, Temsamani

Publikováno v: The Journal of pharmacology and experimental therapeutics. 296(1)

Doxorubicin delivery to the brain is often restricted because of the poor transport of this therapeutic molecule through the blood-brain barrier (BBB). To overcome this problem, we have recently developed a technology, Pep:trans, based on short natur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f3ef5df6a06b98ba076c008b303a5c1f
https://pubmed.ncbi.nlm.nih.gov/11123372