Zobrazeno 1 - 10
of 397
pro vyhledávání: '"J, Stuart Elborn"'
Autor:
Sivagurunathan Sutharsan, Rainald Fischer, Wolfgang Gleiber, Alex Horsley, Jeff Crosby, Shuling Guo, Shuting Xia, Rosie Yu, Kenneth B. Newman, J. Stuart Elborn
Publikováno v:
ERJ Open Research, Vol 10, Iss 4 (2024)
Background Hyperactivity of epithelial sodium channel (ENaC) with increased sodium absorption is a feature of cystic fibrosis (CF). ION-827359 is a 2.5-generation antisense oligonucleotide targeted to reduce ENaC protein. This study evaluated ION-827
Externí odkaz:
https://doaj.org/article/85b98b185ea54aedaea0d4fbe75abcce
Publikováno v:
Journal of Global Antimicrobial Resistance, Vol 36, Iss , Pp 407-410 (2024)
ABSTRACT: Objectives: Gram-negative pathogens causing respiratory infection in people with cystic fibrosis and bronchiectasis are becoming progressively more resistant to conventional antibiotics. Although cefiderocol is licenced for the treatment of
Externí odkaz:
https://doaj.org/article/775938bb17934ee3ab5b0511bb71c32e
Autor:
Theodore G. Liou, Natalia Argel, Fadi Asfour, Perry S. Brown, Barbara A. Chatfield, David R. Cox, Cori L. Daines, Dixie Durham, Jessica A. Francis, Barbara Glover, My Helms, Theresa Heynekamp, John R. Hoidal, Judy L. Jensen, Christiana Kartsonaki, Ruth Keogh, Carol M. Kopecky, Noah Lechtzin, Yanping Li, Jerimiah Lysinger, Osmara Molina, Craig Nakamura, Kristyn A. Packer, Robert Paine, III, Katie R. Poch, Alexandra L. Quittner, Peggy Radford, Abby J. Redway, Scott D. Sagel, Rhonda D. Szczesniak, Shawna Sprandel, Jennifer L. Taylor-Cousar, Jane B. Vroom, Ryan Yoshikawa, John P. Clancy, J. Stuart Elborn, Kenneth N. Olivier, Frederick R. Adler
Publikováno v:
iScience, Vol 27, Iss 3, Pp 108835- (2024)
Summary: Airway inflammation underlies cystic fibrosis (CF) pulmonary exacerbations. In a prospective multicenter study of randomly selected, clinically stable adolescents and adults, we assessed relationships between 24 inflammation-associated molec
Externí odkaz:
https://doaj.org/article/0b6e6acfca2f4e87b4dbc09bc0ef7656
Autor:
Michelle K. Greene, Peter Smyth, Andrew English, Joseph McLaughlin, Magda Bucholc, Janice Bailie, Julie McCarroll, Margaret McDonnell, Alison Watt, George Barnes, Mark Lynch, Kevan Duffin, Gerard Duffy, Claire Lewis, Jacqueline A. James, Alan W. Stitt, Tom Ford, Maurice O'Kane, Taranjit Singh Rai, Anthony J. Bjourson, Christopher Cardwell, J Stuart Elborn, David S. Gibson, Christopher J. Scott
Publikováno v:
Heliyon, Vol 10, Iss 2, Pp e24184- (2024)
Background: With the spread of SARS-CoV-2 impacting upon public health directly and socioeconomically, further information was required to inform policy decisions designed to limit virus spread during the pandemic. This study sought to contribute to
Externí odkaz:
https://doaj.org/article/7d4d4ec7cbc4481399abfb0592ef4565
Autor:
Daniela Savi, Luigi Graziano, Barbara Giordani, Stefano Schiavetto, Corrado De Vito, Giuseppe Migliara, Nicholas J. Simmonds, Paolo Palange, J. Stuart Elborn
Publikováno v:
BMC Pulmonary Medicine, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background Regular physical activity (PA) is a valued part of cystic fibrosis (CF) care. Although the accelerometer, SenseWear Armband (SWA), accurately measures habitual PA in CF, it is mostly used for research purposes. For the first time,
Externí odkaz:
https://doaj.org/article/4a0cc379348c441e8e60d5a2a7eae2a5
Autor:
Leah Cuthbertson, Alan W. Walker, Anna E. Oliver, Geraint B. Rogers, Damian W. Rivett, Thomas H. Hampton, Alix Ashare, J. Stuart Elborn, Anthony De Soyza, Mary P. Carroll, Lucas R. Hoffman, Clare Lanyon, Samuel M. Moskowitz, George A. O’Toole, Julian Parkhill, Paul J. Planet, Charlotte C. Teneback, Michael M. Tunney, Jonathan B. Zuckerman, Kenneth D. Bruce, Christopher J. van der Gast
Publikováno v:
Microbiome, Vol 8, Iss 1, Pp 1-13 (2020)
Abstract Background Chronic infection and concomitant airway inflammation is the leading cause of morbidity and mortality for people living with cystic fibrosis (CF). Although chronic infection in CF is undeniably polymicrobial, involving a lung micr
Externí odkaz:
https://doaj.org/article/9cf945cb5ee8440d8a2afcecf4936353
Autor:
Gisli G. Einarsson, Bart M. Vanaudenaerde, Christopher D. Spence, Andrew J. Lee, Mieke Boon, Geert M. Verleden, J. Stuart Elborn, Lieven J. Dupont, Dirk Van Raemdonck, Deirdre F. Gilpin, Robin Vos, Stijn E. Verleden, Michael M. Tunney
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2022)
To date, investigations of the microbiota in the lungs of people with Cystic Fibrosis (PWCF) have primarily focused on microbial community composition in luminal mucus, with fewer studies observing the microbiota in tissue samples from explanted lung
Externí odkaz:
https://doaj.org/article/e3be9f4b85574b029f366d976f295448
Autor:
Deirdre F. Gilpin, Katie-Ann McGown, Kevin Gallagher, Jose Bengoechea, Amy Dumigan, Gisli Einarsson, J. Stuart Elborn, Michael M. Tunney
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Introduction Bacteria have been extensively implicated in the development of smoking related diseases, such as COPD, by either direct infection or bacteria-mediated inflammation. In response to the health risks associated with tobacco exposu
Externí odkaz:
https://doaj.org/article/f2bb7fba6bb743b1b4d5df591c98faff
Autor:
Theodore G. Liou, Frederick R. Adler, Natalia Argel, Fadi Asfour, Perry S. Brown, Barbara A. Chatfield, Cori L. Daines, Dixie Durham, Jessica A. Francis, Barbara Glover, Theresa Heynekamp, John R. Hoidal, Judy L. Jensen, Ruth Keogh, Carol M. Kopecky, Noah Lechtzin, Yanping Li, Jerimiah Lysinger, Osmara Molina, Craig Nakamura, Kristyn A. Packer, Katie R. Poch, Alexandra L. Quittner, Peggy Radford, Abby J. Redway, Scott D. Sagel, Shawna Sprandel, Jennifer L. Taylor-Cousar, Jane B. Vroom, Ryan Yoshikawa, John P. Clancy, J. Stuart Elborn, Kenneth N. Olivier, David R. Cox
Publikováno v:
BMC Medical Research Methodology, Vol 19, Iss 1, Pp 1-13 (2019)
Abstract Background Biomarkers of inflammation predictive of cystic fibrosis (CF) disease outcomes would increase the power of clinical trials and contribute to better personalization of clinical assessments. A representative patient cohort would imp
Externí odkaz:
https://doaj.org/article/cdeb10f8f67f4a68b3449c8f95764544
Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice
Autor:
Ryan Brown, Donna M. Small, Declan F. Doherty, Leslie Holsinger, Robert Booth, Richard Williams, Rebecca J. Ingram, J. Stuart Elborn, Marcus A. Mall, Clifford C. Taggart, Sinéad Weldon
Publikováno v:
Mediators of Inflammation, Vol 2021 (2021)
Background. Elevated levels of the cysteine protease cathepsin S (CatS) are associated with chronic mucoobstructive lung diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). We have previously demonstrated that prop
Externí odkaz:
https://doaj.org/article/7f801294803e401ab88bd8dd4b1176eb