Zobrazeno 1 - 10
of 313
pro vyhledávání: '"J, Stebbins"'
Autor:
Michael M. Poon, Kym I. Lorrain, Karin J. Stebbins, Geraldine C. Edu, Alexander R. Broadhead, Ariana O. Lorenzana, Bryanna E. Paulson, Christopher S. Baccei, Jeffrey R. Roppe, Thomas O. Schrader, Lino J. Valdez, Yifeng Xiong, Austin C. Chen, Daniel S. Lorrain
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-21 (2024)
Abstract Multiple sclerosis (MS) is a chronic neurological disease characterized by inflammatory demyelination that disrupts neuronal transmission resulting in neurodegeneration progressive disability. While current treatments focus on immunosuppress
Externí odkaz:
https://doaj.org/article/968e173534244880bfd928cf16265e56
Autor:
Scott G. Canfield, Matthew J. Stebbins, Madeline G. Faubion, Benjamin D. Gastfriend, Sean P. Palecek, Eric V. Shusta
Publikováno v:
Fluids and Barriers of the CNS, Vol 16, Iss 1, Pp 1-12 (2019)
Abstract Background Brain microvascular endothelial cells (BMECs) astrocytes, neurons, and pericytes form the neurovascular unit (NVU). Interactions with NVU cells endow BMECs with extremely tight barriers via the expression of tight junction protein
Externí odkaz:
https://doaj.org/article/cf68e44965c54e5da97d6ddc617aba95
Autor:
Miranda R. Sun, Hannah M. Chung, Veronika Matsuk, Dustin M. Fink, Matthew J. Stebbins, Sean P. Palecek, Eric V. Shusta, Robert J. Lipinski
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Sonic hedgehog (Shh) pathway disruption causes craniofacial malformations including orofacial clefts (OFCs) of the lip and palate. In normal craniofacial morphogenesis, Shh signals to multipotent cranial neural crest cells (cNCCs) and was recently di
Externí odkaz:
https://doaj.org/article/e862e1f320e54366bb6d4c3db2bfbf8e
Publikováno v:
Journal of Aircraft. 58:894-906
Icing on three-dimensional lifting surfaces has been shown to produce highly complex flowfields. However, there is a lack of experimental and computational information in the public domain regardin...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0907957c49bec52003ce45f787c4f88f
https://doi.org/10.2514/1.c036188
https://doi.org/10.2514/1.c036188
Autor:
Brandon J. Kim, Olivia B. Bee, Maura A. McDonagh, Matthew J. Stebbins, Sean P. Palecek, Kelly S. Doran, Eric V. Shusta
Publikováno v:
mSphere, Vol 2, Iss 6 (2017)
ABSTRACT Bacterial meningitis is a serious infection of the central nervous system (CNS) that occurs after bacteria interact with and penetrate the blood-brain barrier (BBB). The BBB is comprised of highly specialized brain microvascular endothelial
Externí odkaz:
https://doaj.org/article/59296184a85c450980a4dc35131fedb2
Autor:
Scott G. Canfield, Matthew J. Stebbins, Madeline G. Faubion, Benjamin D. Gastfriend, Sean P. Palecek, Eric V. Shusta
Publikováno v:
Fluids and Barriers of the CNS, Vol 16, Iss 1, Pp 1-1 (2019)
Following publication of the original article [1], the author has reported that in Figure 1 (b and c) the y-axis TEER (© x cm2) should be replaced with TEER (Ω x cm2).
Externí odkaz:
https://doaj.org/article/3b90274842684c01897927a970e60e5b
Autor:
Feng Mei, Klaus Lehmann-Horn, Yun-An A Shen, Kelsey A Rankin, Karin J Stebbins, Daniel S Lorrain, Kara Pekarek, Sharon A Sagan, Lan Xiao, Cory Teuscher, H-Christian von Büdingen, Jürgen Wess, J Josh Lawrence, Ari J Green, Stephen PJ Fancy, Scott S Zamvil, Jonah R Chan
Publikováno v:
eLife, Vol 5 (2016)
Demyelination in MS disrupts nerve signals and contributes to axon degeneration. While remyelination promises to restore lost function, it remains unclear whether remyelination will prevent axonal loss. Inflammatory demyelination is accompanied by si
Externí odkaz:
https://doaj.org/article/4da806c40b4949a2851d1bc03be524f7
Autor:
Daniel S. Lorrain, Ariana O Lorenzana, Alexander Broadhead, Christopher Baccei, Xiong Yifeng, Thomas O. Schrader, Michael M Poon, Karin J. Stebbins
Publikováno v:
ACS Medicinal Chemistry Letters. 12:155-161
The discovery of PIPE-359, a brain-penetrant and selective antagonist of the muscarinic acetylcholine receptor subtype 1 is described. Starting from a literature-reported M1 antagonist, linker replacement and structure-activity relationship investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::430b568160efae9b410358b8f2bedc3b
https://doi.org/10.1021/acsmedchemlett.0c00626
https://doi.org/10.1021/acsmedchemlett.0c00626
Autor:
Spencer J. Stebbins, Eric Loth
Publikováno v:
AIAA SCITECH 2022 Forum.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a97d73328e761e1b00962c98c39eb8b
https://doi.org/10.2514/6.2022-1170
https://doi.org/10.2514/6.2022-1170
Publikováno v:
Gait & Posture. 97:S266-S267
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03e41b29fc785bb6b6a9381f3c34c2a1
https://doi.org/10.1016/j.gaitpost.2022.07.161
https://doi.org/10.1016/j.gaitpost.2022.07.161