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Identification of neoepitope reactive T-cell receptors guided by HLA-A*03:01 and HLA-A*11:01 immunopeptidomics

Autor: Xu Zhang, Sudipto Das, Zhiya Yu, Ken-ichi Hanada, James C Yang, Thorkell Andresson, Catherine M Ade, Matthew J Sporn, Yue A Qi, Tapan Maity, Udayan Guha

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 9 (2023)

Background Tumor-specific mutated proteins can create immunogenic non-self, mutation-containing ‘neoepitopes’ that are attractive targets for adoptive T-cell therapies. To avoid the complexity of defining patient-specific, private neoepitopes, th

Externí odkaz: https://doaj.org/article/58a08e7c3c1e4ebdb8cc548abf290a85

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R-(-)-ketamine modifies behavioral effects of morphine predicting efficacy as a novel therapy for opioid use disorder

Autor: J M, Witkin, J, Kranzler, K, Kaniecki, P, Popik, J L, Smith, K, Hashimoto, J, Sporn

Publikováno v: Pharmacology, biochemistry, and behavior. 194

Substance abuse disorder continues to have devastating consequences for individuals and society and current therapies are not sufficient to provide the magnitude of medical impact required. Although some evidence suggests the use of ketamine in treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::894ec80e82775545e76ae4a1635d6903
https://pubmed.ncbi.nlm.nih.gov/32333922

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Sexual health communication between cancer survivors and providers: how frequently does it occur and which providers are preferred?

Autor: Nora J, Sporn, Kelly B, Smith, William F, Pirl, Inga T, Lennes, Kelly A, Hyland, Elyse R, Park

Publikováno v: Psycho-oncology. 24(9)

Sexual health concerns in cancer survivors are often unaddressed by providers. Study objectives were to assess cancer survivors' reported rates of communication with oncology providers about sexual health, preference for such communication with their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2037e3a5e4ff821ed048767107879025
https://pubmed.ncbi.nlm.nih.gov/25534170

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Early Referral for 24-Hour Esophageal pH Monitoring May Prevent Unnecessary Treatment With Acid-Reducing Medications

Autor: Toni Beninato, Rasa Zarnegar, David A. Kleiman, Yasmin Metz, Carl V. Crawford, Matthew J. Sporn, Thomas J. Fahey

Gastroesophageal reflux disease (GERD) affects nearly 25 % of adults; however, an objective diagnosis is rarely established. We hypothesized that patients’ symptoms and response to acid-reducing therapy are poor predictors of the outcome of 24-h es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0247545fd3590731d17f804ecfd668af
https://europepmc.org/articles/PMC3996557/

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Preoperative BRAF(V600E) mutation screening is unlikely to alter initial surgical treatment of patients with indeterminate thyroid nodules: a prospective case series of 960 patients

Autor: Anvy Nguyen, Rasa Zarnegar, Theresa Scognamiglio, David A. Kleiman, Matthew J. Sporn, Thomas J. Fahey, Alessia Uccelli, Toni Beninato, Michael J. Crowley

Publikováno v: Cancer. 119(8)

BACKGROUND: Preoperative B-type Raf kinase Val600Glu mutation, or BRAF(V600E), analysis has been proposed as a tool to guide initial surgery for indeterminate thyroid nodules. This study sought to determine if cytologic markers of malignancy are asso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d2730143dbbeca371385d5c6ad762c
https://pubmed.ncbi.nlm.nih.gov/24353098

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Pregabalin bei HIV-Infektion

Autor: Birol Emir, M L Chew, Andrew S.C. Rice, Jaren W. Landen, David Semel, J Sporn, David M. Simpson

Publikováno v: Journal Club Schmerzmedizin. 4:37-37

Bei Patienten mit einer HIV-Infektion kommt es haufig zu einer peripheren, symmetrischen, distal beginnenden sensorischen Neuropathie, resultierend aus einer Nervenschadigung durch das Virus selbst oder durch die antiretrovirale Therapie. Pregabalin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1ba547224e36df3a19e4fc53340ab3c
https://doi.org/10.1055/s-0035-1550419

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Pramipexole augmentation in the treatment of unipolar and bipolar depression: a retrospective chart review

Autor: J, Sporn, S N, Ghaemi, M R, Sambur, M A, Rankin, J, Recht, G S, Sachs, J F, Rosenbaum, M, Fava

Publikováno v: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists. 12(3)

To assess the effectiveness and safety of pramipexole as an adjunctive medication in refractory bipolar and unipolar depression in a naturalistic setting.Retrospective chart review by psychiatrists on staff at a university hospital identified all pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::87f73489d743b946f030ebc6fccc5aeb
https://pubmed.ncbi.nlm.nih.gov/10984002

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